RAP1GAP Antibody - C-terminal region (OASG06266)

Catalog No: OASG06266

Size:100 uL

Western Blot using COLO205

Western Blot using Jurkat, HuvEc

Product Info

• Predicted Species Reactivity: Human, Mouse
• Product Format: Liquid. 1 mg/mL in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Application: WB, IHC
• Reconstitution and Storage: Store at -20C. Avoid repeated freeze/thaw cycles.
• Immunogen: Synthesized peptide derived from the C-terminal region of human Rap1GAP. Location: 460-540aa.
• Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Concentration: 1 mg/ml
• Specificity: Rap1GAP Polyclonal Antibody detects endogenous levels of Rap1GAP protein.
• Application Info: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:10000;

Target Info

• Gene Symbol: RAP1GAP
• Gene Full Name: RAP1 GTPase activating protein
• Alias Symbols: RAPGAP, RAP1GA1, RAP1GAP1, RAP1GAPII
• NCBI Gene Id: 5909;
• Description of Target: This gene encodes a type of GTPase-activating-protein (GAP) that down-regulates the activity of the ras-related RAP1 protein. RAP1 acts as a molecular switch by cycling between an inactive GDP-bound form and an active GTP-bound form. The product of this gene, RAP1GAP, promotes the hydrolysis of bound GTP and hence returns RAP1 to the inactive state whereas other proteins, guanine nucleotide exchange factors (GEFs), act as RAP1 activators by facilitating the conversion of RAP1 from the GDP- to the GTP-bound form. In general, ras subfamily proteins, such as RAP1, play key roles in receptor-linked signaling pathways that control cell growth and differentiation. RAP1 plays a role in diverse processes such as cell proliferation, adhesion, differentiation, and embryogenesis. Alternative splicing results in multiple transcript variants encoding distinct proteins.
• Uniprot ID: P47736
• Molecular Weight: 73 kDa