PTK2B Antibody - C-terminal region (ARP32684_T100)

Catalog No: ARP32684_T100

WB Suggested Anti-PTK2B Antibody Titration: 1.25ug/ml
Positive Control: Raji cell lysatePTK2B is strongly supported by BioGPS gene expression data to be expressed in Human Raji cells

Product Info

• Tested Species Reactivity: Human
• Predicted Species Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Clonality: Polyclonal
• Host: Rabbit
• Application: WB
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human PTK2B
• Purification: Protein A purified
• Predicted Homology Based on Immunogen Sequence: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%
• Peptide Sequence: Synthetic peptide located within the following region: QKQMVEDYQWLRQEEKSLDPMVYMNDKSPLTPEKEVGYLEFTGPPQKPPR
• Concentration: 1.0 mg/ml
• Blocking Peptide: For anti-PTK2B (ARP32684_T100) antibody is Catalog # AAP32684 (Previous Catalog # AAPP03694)
• Sample Type Confirmation:

  PTK2B is strongly supported by BioGPS gene expression data to be expressed in Raji

• Reference: Ling,S., et al., (2004) Am. J. Cell Physiol. 287 (3), C698-C706

Target Info

• Gene Symbol: PTK2B
• Gene Full Name: PTK2B protein tyrosine kinase 2 beta
• Alias Symbols: PKB, PTK, CAKB, FAK2, PYK2, CADTK, FADK2, RAFTK
• NCBI Gene Id: 2185
• Protein Name: Protein-tyrosine kinase 2-beta
• Description of Target: PTK2B encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies.
• Uniprot ID: Q14289
• Protein Accession #: NP_004094
• Nucleotide Accession #: NM_004103
• Protein Size (# AA): 1009
• Molecular Weight: 116kDa
• Protein Interactions: CBLB; UBC; EGFR; PXN; HSP90AA1; MAPT; GP6; TRAF4; BCAR1; SKAP2; GP1BB; UL49; SOCS3; SRC; GRB2; FYN; DNM1; ALG2; SH3KBP1; PDCD6IP; CBL; SOCS2; PTEN; MBD2; DLGAP3; STAP1; SORBS2; NEDD9; EFS; NPHP1; PITPNM2; PITPNM3; PITPNM1; ARHGAP21; RB1CC1; ASAP1; LPXN; P