Huma BACE1 (Partial length)(50ug)

Catalog#: AEP00003

• Description of Target: Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein (APP) by two proteases, one of which is the protein encoded by BACE-1. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi. Four transcript variants encoding different isoforms of BACE-1 have been described.
• Gene Symbol: BACE1
• Alias Symbols: ASP2; BACE; APP beta-secretase; asp 2; aspartyl protease 2; beta-secretase 1; beta-secretase 1 precursor variant 1; beta-site APP cleaving enzyme 1; beta-site amyloid beta A4 precursor protein-cleaving enzyme; beta-site amyloid precursor protein cleaving
• Protein Accession#: NP_036236
• Nucleotide Accession#: NM_012104
• Swissprot Id: P56817
• Protein Size (# AA): 501
• Molecular Weight: 55kDa
• Protein Sequence: LPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTV
• Tag: None
• Reconstitution and Storage: Already in solution (1mg/ml). For longer periods of storage, store at -20°C. Avoid repeat freeze and thaw cycles.
• Key Reference: Nogalska,A., et al., (2010) Neurosci. Lett. 474 (3), 140-143