- Description of Target:
- HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. TARDBP is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription.HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
- Gene Symbol:
- HNRNPA0
- Alias Symbols:
- HNRPA0
- Protein Accession# :
- NP_006796
- Nucleotide Accession#:
- NM_006805
- Swissprot Id:
- Q13151
- Protein Size (# AA):
- 305
- Molecular Weight:
- 34kDa
- Partner Proteins:
- ACHE, HEXB, RAD51
- Tag:
- GST
- Quality Control:
- This product was tested on western blot.
- Reconstitution and Storage:
- Add 100ul of distilled water. Final concentration is 1 mg/ml. For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
- Additional Information:
- Buffer Formulation: 0.1M Tris-HCl (pH 6.8) buffer containing 0.2M DTT, 4% SDS, 0.2% Bromophenol blue and 20% Sucrose.
- Key Reference:
- Lai,F., (2001) Genomics 71 (2), 235-245
- Datasheets / Downloads:
- APL00004
- Protocol:
- Tips Information:
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