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Catalog No: OPCB00016
Size:2ug
Price: $165.00
SKU
OPCB00016
Availability: Domestic: within 1-2 week delivery | International: within 1-2 week delivery
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Datasheets/ManualsPrintable datasheet for Biotinylated CCL5 Protein (OPCB00016)
Product Info
Product FormatLyophilized
ConjugationBiotin
ApplicationCA
::Endotoxin Level: <0.01 EU per 1ug of the protein by the LAL method
Reconstitution and StorageRecommended at 100ug/mL in sterile water
Shipping: Room Temp
Purity> 97% as determined by SDS-PAGE
Biological ActivityEC50 = 0.25-0.50nM determined by Migration Assay of recombinant CCR5 containing cells
SourceE. coli
Reference1. "RANTES: a versatile and controversial chemokine"
Appay V., Rowland-Jones S.L.
Trends Immunol 22:83-87 (2001)
2. "Identification of RANTES, MIP-1, and MIP-1[1] as the major HIV-suppressive factors produced by CD8+T cells"
Cocchi F., De Vico A.L., Garzino-Demo A., Arya S.K., Gallo R.C., Lusso P.
Science 270:1811-1815 (1995)
3. A human T cell-specific molecule is a member of a new gene family
Schall T.J., Jongstra J., Dyer B.J., Jorgensen J., Clayberger C., Davis M.M., Krensky A.M.
J Immunol 141:1018-1025 (1988)
4. "Engineering the glycosaminoglycan-binding affinity, kinetics and oligomerization behavior of RANTES: a tool for generating chemokine-based glycosaminoglycan antagonists"
Brandner B., Rek A., Diedrichs-Möhring M., Wildner G., Kungl A.J.
Protein Eng Des Sel. 22:367-373 (2009)
Gene SymbolCCL5
Gene Full Namechemokine (C-C motif) ligand 5
Alias SymbolsSISd, eoCP, SCYA5, RANTES, TCP228, D17S136E, SIS-delta
NCBI Gene Id6352
Description of TargetRegulated on Activation, Normal T cell Expressed and Secreted (RANTES) (CCL5) is a proinflammatory chemokine that induces migration and activation of leukocytes, as well as implication in HIV infection. It binds to cell surface receptors CCR1, CCR3, CCR4, and CCR5. Its biological effects on leukocyte activation and HIV infection displays dependence on concentration and on the binding of cell surface glycosaminoglycans.
Uniprot IDP13501
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