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BACE1 Protein (AEP00003)

  • Catalog#: AEP00003
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50 ug
$399.00
Discontinued
Gene Symbol:
BACE1
Official Gene Full Name:
beta-site APP-cleaving enzyme 1
NCBI Gene Id:
23621
Alias Symbols:
ASP2, BACE, HSPC104
Description of Target:
This gene encodes a member of the peptidase A1 family of aspartic proteases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protease. This transmembrane protease catalyzes the first step in the formation of amyloid beta peptide from amyloid precursor protein. Amyloid beta peptides are the main constituent of amyloid beta plaques, which accumulate in the brains of human Alzheimer's disease patients.
Swissprot Id:
P56817
Protein Accession #:
NP_036236
Nucleotide Accession #:
NM_012104
Protein Name:
Beta-secretase 1
Protein Size (# AA):
501
Molecular Weight:
55kDa
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express BACE1.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express BACE1.
Protein Interactions:
COPS5; BRI3; RANBP9; APP; PCSK9; GGA1; GGA3; GGA2; UBC; FBXO2; CMPK1; ITM2C; KHSRP; PLSCR1; NCSTN; PDIA3; CSNK1D; SELPLG; ATP1B1; PSAP; FURIN; MMP2; LRP1; PSEN1;
Product Format:
Lyophilized powder
Species Reactivity:
Human
Protein Sequence:
LPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTV
Application:
WB
Tag:
None
Reconstitution and Storage:
Reconstitute with distilled water. For longer periods of storage, store at -20C. Avoid repeat freeze and thaw cycles.
Target Reference:
Nogalska,A., et al., (2010) Neurosci. Lett. 474 (3), 140-143
Datasheets / Downloads:
Printable datasheet for anti-BACE1 (AEP00003) antibody
 
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