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Transcription Regulators Antibodies

Aviva Systems Biology manufactures over 3,000 antibodies for transcription factor research. These proteins have become an important tool for research associated with gene regulation. Transcription regulators control the rate and timing of gene transcription in a cell. A number of proteins govern this fundamental process by various mechanisms. Transcription factors can bind to promoter or enhancer regions of DNA and serve to promote or impede gene transcription. These bound transcription factors may be classified as activators or repressors. Activators aid in the recruitment of RNA polymerase to a given promoter region, thereby ‘activating’ the transcription process. The level of transcription may be enhanced by binding of proteins to specific regions of DNA known as enhancers. These regions are important in the control of gene expression levels, although they need not be near the target gene to function[1]. Repressors bind to areas of DNA (known as operators) that are close to promoters and act to block the function of RNA polymerase and thus inhibit the transcription process. The binding affinity of repressors can be altered by inducers, which promote transcription, and corepressors, which further repress transcription. Other proteins, such as Histone Deacetylases (HDACs), can modify the accessibility of DNA to transcriptional machinery and thus serve as regulators transcription regulators.

1. Spilianakis CG et al. 2005. Interchromosomal associations between alternatively expressed loci. Nature. Jun 2;435(7042):637-45.

Nucleotide sequences of a gene that are involved in the regulation of Transcription (The biosynthesis of RNA carried out on a template of DNA). They are involved in transcription as repressors or promoters. We have manufactured about 1800 antibody products for them.

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  • TRIAL 
    VSX1 antibody - middle region (ARP35883_P050) in Human Liver using Western Blot

    VSX1 antibody - middle region (ARP35883_P050)

    Protein Name:Visual system homeobox 1
    Catalog #:ARP35883_P050
    Type: pAb
    Reacts with: Cow, Dog, Horse, Human, Mouse, Pig, Yeast
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    VPS72 antibody - N-terminal region (ARP33348_P050) in Human ACHN using Western Blot

    VPS72 antibody - N-terminal region (ARP33348_P050)

    Protein Name:Vacuolar protein sorting-associated protein 72 homolog
    Catalog #:ARP33348_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
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    VDR antibody - N-terminal region (ARP37987_P050) in Human Brain using Western Blot
    VDR antibody - N-terminal region (ARP37987_P050) in Hum. Fetal Heart using Western Blot
    VDR antibody - N-terminal region (ARP37987_P050) in Hum. Fetal Liver using Western Blot
    VDR antibody - N-terminal region (ARP37987_P050) in Hum. Fetal Muscle using Western Blot

    VDR antibody - N-terminal region (ARP37987_P050)

    Protein Name:Vitamin D3 receptor
    Catalog #:ARP37987_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
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