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Transcription Factor Antibodies

Transcription factors are proteins that regulate gene expression by binding to DNA via one or more DNA-binding domains. This binding is achieved via a combination of electrostatic and van der waals forces and can occur at many closely-related sequences flanking different genes. Once bound to DNA directly or as part of a complex, they can promote or inhibit RNA polymerase recruitment, thereby acting as activators or repressors, respectively. Alternatively, transcription factors can act to recruit coactivators and corepressors or to catalyze histone acetylation and deacetylation. Transcription factors can function downstream of signaling cascades triggered by biological or environmental (ex. hypoxia, hyperthermia) stimuli to alter the expression of target genes. Ligand binding is necessary to activate some transcription factors as this can cause nuclear translocation and changes in the binding affinities for DNA and cofactors. During development, various stimuli can cause transcription factors to up- or down-regulate expression of specific genes at distinct time points to ensure proper development. Transcription factors can function as oncogenes or tumor suppressors and have thus been linked to various cancers. Accordingly, some therapeutic approaches in cancer therapy involve targeting transcription factor families[1].

1. Darnell JE Jr. 2002. Transcription factors as targets for cancer therapy. Nat Rev Cancer. Oct;2(10):740-9.

Transcription Factor Antibodies Top 20 Showcase

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Transcription Factors are involved in transcriptional regulation in the form of up regulation or down regulation acting as either repressors or activators of transcription. We have manufactured more than 3000 antibody products covering almost every known human and mouse transcription factors.

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Showing 151 - 180 of 4061
  Type Catalog # Product Product Images Price (USD)
  pAb ARP39491_P050 ZN410 Antibody - C-terminal region (ARP39491_P050)
Reacts with
Human
Application
WB
$289.00
  pAb ARP30075_P050 ZIC4 Antibody - C-terminal region (ARP30075_P050)
Reacts with
Human
Application
WB
$289.00
  pAb ARP36818_P050 ALX3 Antibody - C-terminal region (ARP36818_P050)
Reacts with
Human
Application
WB
$289.00
  pAb ARP61523_P050 SSXT Antibody - C-terminal region (ARP61523_P050)
Reacts with
Human
Application
WB
$289.00
  pAb ARP34971_P050 ACHB3 Antibody - N-terminal region (ARP34971_P050)
Reacts with
Human
Application
WB
$289.00
  pAb ARP39579_P050 HXA6 Antibody - N-terminal region (ARP39579_P050)
Reacts with
Human
Application
WB
$289.00
  pAb ARP30310_P050 P53 Antibody - C-terminal region (ARP30310_P050)
Reacts with
Human
Application
WB
$289.00
  pAb ARP32063_P050 PAX3 Antibody - C-terminal region (ARP32063_P050)
Reacts with
Human
Application
WB
$289.00
  pAb ARP57912_P050 TRI26 Antibody - C-terminal region (ARP57912_P050)
Reacts with
Human
Application
WB
$289.00
  pAb ARP33584_P050 SNIP1 Antibody - C-terminal region (ARP33584_P050)
Reacts with
Human
Application
WB
$289.00
  pAb ARP35947_P050 ZN358 Antibody - C-terminal region (ARP35947_P050)
Reacts with
Human
Application
WB
$289.00
  pAb ARP50661_P050 ZN273 Antibody - C-terminal region (ARP50661_P050)
Reacts with
Human
Application
WB
$289.00
  pAb ARP40083_P050 TRI41 Antibody - N-terminal region (ARP40083_P050)
Reacts with
Human
Application
WB
$289.00
  pAb ARP45605_P050 NR4A1 Antibody - C-terminal region (ARP45605_P050)
Reacts with
Human, Horse, Guinea pig, Dog, Bovine, Rabbit, Mouse, Rat, Zebrafish
Application
WB
$289.00
  pAb ARP38434_T100 TRIP13 antibody - C-terminal region (ARP38434_T100)
Reacts with
Dog, Horse, Human, Rabbit, Bovine, Rat, Mouse, Pig, Guinea pig
Application
IHC, WB
$229.00
  pAb ARP72430_P050 PTRF Antibody - C-terminal region (ARP72430_P050)
Reacts with
Human
Application
WB
$289.00
  pAb ARP45604_P050 NR4A1 antibody - middle region (ARP45604_P050)
Reacts with
Human, Horse, Rabbit, Rat, Guinea pig, Dog, Mouse, Bovine
Application
IHC, WB
$289.00
  pAb ARP35782_P050 SSX4 antibody - N-terminal region (ARP35782_P050)
Reacts with
Human, Bovine
Application
WB
$289.00
  pAb ARP35724_T100 TRIP13 antibody - N-terminal region (ARP35724_T100)
Reacts with
Bovine, Horse, Rabbit, Guinea pig, Human, Rat, Mouse, Dog
Application
IHC, WB
$229.00
  pAb ARP33721_T100 MORF4L2 antibody - N-terminal region (ARP33721_T100)
Reacts with
Mouse, Human, Dog, Pig, Horse, Rabbit, Rat, Bovine, Guinea pig
Application
IHC, WB
$229.00
  pAb ARP35783_P050 SSX4 antibody - middle region (ARP35783_P050)
Reacts with
Human
Application
IHC, WB
$289.00
  pAb ARP38433_P050 TRIP13 antibody - N-terminal region (ARP38433_P050)
Reacts with
Human, Pig, Dog, Bovine, Rabbit, Rat, Guinea pig, Mouse
Application
WB
$289.00
  pAb ARP33059_P050 SLC38A2 antibody - N-terminal region (ARP33059_P050)
Reacts with
Pig, Human, Bovine, Dog, Horse, Rabbit, Rat, Guinea pig, Mouse
Application
WB
$289.00
  pAb ARP30036_T100 GLIS2 antibody - N-terminal region (ARP30036_T100)
Reacts with
Human, Dog, Rat, Guinea pig, Rabbit, Mouse, Horse
Application
WB
$229.00
  pAb ARP34415_T100 PCGF3 antibody - middle region (ARP34415_T100)
Reacts with
Human, Dog, Rat, Bovine, Pig, Mouse, Rabbit, Horse, Guinea pig, Yeast
Application
WB
$229.00
  pAb ARP50423_P050 SSX4B antibody - middle region (ARP50423_P050)
Reacts with
Human
Application
WB
$289.00
  pAb ARP55368_P050 FGF21 antibody - N-terminal region (ARP55368_P050)
Reacts with
Pig, Bovine, Dog, Horse, Rat, Guinea pig, Mouse, Human, Rabbit
Application
IHC, WB
$289.00
  pAb ARP34416_P050 PCGF3 antibody - middle region (ARP34416_P050)
Reacts with
Human, Horse, Pig, Dog, Bovine, Rat, Rabbit, Guinea pig, Mouse
Application
WB
$289.00
  pAb ARP33720_T100 MORF4L2 antibody - N-terminal region (ARP33720_T100)
Reacts with
Human, Mouse, Dog, Pig, Horse, Rabbit, Rat, Yeast, Bovine, Guinea pig
Application
IHC, WB
$229.00
  pAb ARP50349_P050 ZNF599 antibody - N-terminal region (ARP50349_P050)
Reacts with
Human, Bovine
Application
WB
$289.00

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Showing 151 - 180 of 4061