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Transcription Factor Antibodies

Transcription factors are proteins that regulate gene expression by binding to DNA via one or more DNA-binding domains. This binding is achieved via a combination of electrostatic and van der waals forces and can occur at many closely-related sequences flanking different genes. Once bound to DNA directly or as part of a complex, they can promote or inhibit RNA polymerase recruitment, thereby acting as activators or repressors, respectively. Alternatively, transcription factors can act to recruit coactivators and corepressors or to catalyze histone acetylation and deacetylation. Transcription factors can function downstream of signaling cascades triggered by biological or environmental (ex. hypoxia, hyperthermia) stimuli to alter the expression of target genes. Ligand binding is necessary to activate some transcription factors as this can cause nuclear translocation and changes in the binding affinities for DNA and cofactors. During development, various stimuli can cause transcription factors to up- or down-regulate expression of specific genes at distinct time points to ensure proper development. Transcription factors can function as oncogenes or tumor suppressors and have thus been linked to various cancers. Accordingly, some therapeutic approaches in cancer therapy involve targeting transcription factor families[1].

1. Darnell JE Jr. 2002. Transcription factors as targets for cancer therapy. Nat Rev Cancer. Oct;2(10):740-9.

Transcription Factor Antibodies Top 20 Showcase

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Transcription Factors are involved in transcriptional regulation in the form of up regulation or down regulation acting as either repressors or activators of transcription. We have manufactured more than 3000 antibody products covering almost every known human and mouse transcription factors.

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Showing 151 - 180 of 4219
  • TRIAL 
    NR6A1 Antibody (ARP31865_P050) in Human Lymph Node Tumor using Western Blot

    NR6A1 Antibody - middle region (ARP31865_P050)

    Protein Name:Nuclear receptor subfamily 6 group A member 1
    Catalog #:ARP31865_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Sheep, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  •  
    ZFP106 Antibody - N-terminal region (ARP79361_P050) in Human 786-0 Whole Cell using Western Blot

    ZFP106 Antibody - N-terminal region (ARP79361_P050)

    Protein Name:zinc finger protein 106
    Catalog #:ARP79361_P050
    Type: pAb
    Reacts with: Human
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    ID1 Antibody (ARP30573_P050) in Human Hela Whole Cell using Western Blot
    ID1 Antibody - middle region (ARP30573_P050) in human heart using Immunohistochemistry

    ID1 Antibody - middle region (ARP30573_P050)

    Protein Name:DNA-binding protein inhibitor ID-1
    Catalog #:ARP30573_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
    Application: WB, IHC
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    LPPRC Antibody (ARP41093_P050) in Human 293T Whole Cell using Western Blot

    LPPRC Antibody - N-terminal region (ARP41093_P050)

    Protein Name:Leucine-rich PPR motif-containing protein, mitochondrial
    Catalog #:ARP41093_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    SDPR Antibody - N-terminal region (ARP76755_P050) in Human leiomyosarcoma using Western Blot

    SDPR Antibody - N-terminal region (ARP76755_P050)

    Protein Name:serum deprivation-response protein
    Catalog #:ARP76755_P050
    Type: pAb
    Reacts with: Human
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    SNPC5 Antibody (ARP57931_P050) in Human Ovary Tumor using Western Blot

    SNPC5 Antibody - C-terminal region (ARP57931_P050)

    Protein Name:snRNA-activating protein complex subunit 5
    Catalog #:ARP57931_P050
    Type: pAb
    Reacts with: Cow, Dog, Horse, Human, Pig
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00

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Showing 151 - 180 of 4219