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Transcription Factor Antibodies

Transcription factors are proteins that regulate gene expression by binding to DNA via one or more DNA-binding domains. This binding is achieved via a combination of electrostatic and van der waals forces and can occur at many closely-related sequences flanking different genes. Once bound to DNA directly or as part of a complex, they can promote or inhibit RNA polymerase recruitment, thereby acting as activators or repressors, respectively. Alternatively, transcription factors can act to recruit coactivators and corepressors or to catalyze histone acetylation and deacetylation. Transcription factors can function downstream of signaling cascades triggered by biological or environmental (ex. hypoxia, hyperthermia) stimuli to alter the expression of target genes. Ligand binding is necessary to activate some transcription factors as this can cause nuclear translocation and changes in the binding affinities for DNA and cofactors. During development, various stimuli can cause transcription factors to up- or down-regulate expression of specific genes at distinct time points to ensure proper development. Transcription factors can function as oncogenes or tumor suppressors and have thus been linked to various cancers. Accordingly, some therapeutic approaches in cancer therapy involve targeting transcription factor families[1].

1. Darnell JE Jr. 2002. Transcription factors as targets for cancer therapy. Nat Rev Cancer. Oct;2(10):740-9.

Transcription Factor Antibodies Top 20 Showcase

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Transcription Factors are involved in transcriptional regulation in the form of up regulation or down regulation acting as either repressors or activators of transcription. We have manufactured more than 3000 antibody products covering almost every known human and mouse transcription factors.

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Showing 151 - 180 of 4220
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    HSPA5 Antibody - middle region (ARP79109_P050) in Human Liver Tumor using Western Blot

    HSPA5 Antibody - middle region (ARP79109_P050)

    Protein Name:78 kDa glucose-regulated protein
    Catalog #:ARP79109_P050
    Type: pAb
    Reacts with: Human
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 

    PSMD4 Antibody - C-terminal region (ARP58059_P050)

    Protein Name:26S proteasome non-ATPase regulatory subunit 4
    Catalog #:ARP58059_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Sheep, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    ZIC4 Antibody (ARP30075_P050) in Human 721_B Whole Cell using Western Blot

    ZIC4 Antibody - C-terminal region (ARP30075_P050)

    Protein Name:Zinc finger protein ZIC 4
    Catalog #:ARP30075_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
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    TAF5L Antibody - middle region (ARP74858_P050) in Human U937 Whole Cell using Western Blot

    TAF5L Antibody - middle region (ARP74858_P050)

    Protein Name:TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L
    Catalog #:ARP74858_P050
    Type: pAb
    Reacts with: Human
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    P53 Antibody (ARP30310_P050) in Human Fetal Kidney using Western Blot

    P53 Antibody - C-terminal region (ARP30310_P050)

    Protein Name:Cellular tumor antigen p53
    Catalog #:ARP30310_P050
    Type: pAb
    Reacts with: Dog, Human, Pig, Rabbit, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    FEZF2 Antibody (ARP33140_P050) in Human PANC1 Whole Cell using Western Blot

    FEZF2 Antibody - C-terminal region (ARP33140_P050)

    Protein Name:Fez family zinc finger protein 2
    Catalog #:ARP33140_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    ZFY Antibody (ARP33500_P050) in Human ACHN Whole Cell using Western Blot

    ZFY Antibody - C-terminal region (ARP33500_P050)

    Protein Name:Zinc finger Y-chromosomal protein
    Catalog #:ARP33500_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    PAX6 Antibody (ARP38063_P050) in Human 786-0 Whole Cell using Western Blot

    PAX6 Antibody - C-terminal region (ARP38063_P050)

    Protein Name:Paired box protein Pax-6
    Catalog #:ARP38063_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat, Sheep, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    TRI41 Antibody (ARP40083_P050) in Human HepG2 Whole Cell using Western Blot

    TRI41 Antibody - N-terminal region (ARP40083_P050)

    Protein Name:E3 ubiquitin-protein ligase TRIM41
    Catalog #:ARP40083_P050
    Type: pAb
    Reacts with: Dog, Horse, Human, Mouse, Pig, Rabbit, Rat, Yeast
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    TFAP2C Antibody - N-terminal region (ARP76649_P050) in Human large intestine Tumor using Western Blot

    TFAP2C Antibody - N-terminal region (ARP76649_P050)

    Protein Name:transcription factor AP-2 gamma
    Catalog #:ARP76649_P050
    Type: pAb
    Reacts with: Human
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    TRI26 Antibody (ARP57912_P050) in Human Fetal Lung using Western Blot

    TRI26 Antibody - C-terminal region (ARP57912_P050)

    Protein Name:Tripartite motif-containing protein 26
    Catalog #:ARP57912_P050
    Type: pAb
    Reacts with: Cow, Dog, Horse, Human, Mouse, Pig, Rabbit, Rat, Yeast, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    PAK6 Antibody (ARP32119_P050) in Human HepG2 Whole Cell using Western Blot

    PAK6 Antibody - C-terminal region (ARP32119_P050)

    Protein Name:Serine/threonine-protein kinase PAK 6
    Catalog #:ARP32119_P050
    Type: pAb
    Reacts with: Cow, Dog, Goat, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00

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Showing 151 - 180 of 4220