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Transcription Factor Antibodies

Transcription factors are proteins that regulate gene expression by binding to DNA via one or more DNA-binding domains. This binding is achieved via a combination of electrostatic and van der waals forces and can occur at many closely-related sequences flanking different genes. Once bound to DNA directly or as part of a complex, they can promote or inhibit RNA polymerase recruitment, thereby acting as activators or repressors, respectively. Alternatively, transcription factors can act to recruit coactivators and corepressors or to catalyze histone acetylation and deacetylation. Transcription factors can function downstream of signaling cascades triggered by biological or environmental (ex. hypoxia, hyperthermia) stimuli to alter the expression of target genes. Ligand binding is necessary to activate some transcription factors as this can cause nuclear translocation and changes in the binding affinities for DNA and cofactors. During development, various stimuli can cause transcription factors to up- or down-regulate expression of specific genes at distinct time points to ensure proper development. Transcription factors can function as oncogenes or tumor suppressors and have thus been linked to various cancers. Accordingly, some therapeutic approaches in cancer therapy involve targeting transcription factor families[1].

1. Darnell JE Jr. 2002. Transcription factors as targets for cancer therapy. Nat Rev Cancer. Oct;2(10):740-9.

Transcription Factor Antibodies Top 20 Showcase

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Transcription Factors are involved in transcriptional regulation in the form of up regulation or down regulation acting as either repressors or activators of transcription. We have manufactured more than 3000 antibody products covering almost every known human and mouse transcription factors.

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Showing 631 - 660 of 4219
  • TRIAL 
    ESCO1 antibody - N-terminal region (ARP48979_P050) in Human PANC1 using Western Blot

    ESCO1 antibody - N-terminal region (ARP48979_P050)

    Protein Name:N-acetyltransferase ESCO1
    Catalog #:ARP48979_P050
    Type: pAb
    Reacts with: Cow, Dog, Horse, Human, Pig, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    CDK2 antibody - middle region (ARP30331_P050) in Human Jurkat using Western Blot
    CDK2 antibody - middle region (ARP30331_P050) in human liver tissue using Immunohistochemistry

    CDK2 antibody - middle region (ARP30331_P050)

    Protein Name:Cyclin-dependent kinase 2
    Catalog #:ARP30331_P050
    Type: pAb
    Reacts with: Cow, Goat, Guinea Pig, Human, Mouse, Rabbit, Rat, Sheep, Zebrafish
    Application: WB, IHC
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    TCF7 Antibody - N-terminal region (ARP39661_P050) in Human Pancreas Tumor using Western Blot

    TCF7 Antibody - N-terminal region (ARP39661_P050)

    Protein Name:Transcription factor 7
    Catalog #:ARP39661_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Human, Mouse, Rat, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    HNF1B antibody - N-terminal region (ARP32320_T100) in Human Jurkat using Western Blot

    HNF1B antibody - N-terminal region (ARP32320_T100)

    Protein Name:
    Catalog #:ARP32320_T100
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rat, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $229.00
  • TRIAL 
    Hoxa2 antibody - N-terminal region (ARP38855_P050) in Mouse Heart using Western Blot

    Hoxa2 antibody - N-terminal region (ARP38855_P050)

    Protein Name:Homeobox protein Hox-A2
    Catalog #:ARP38855_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    INTS4 Antibody - C-terminal region (ARP51695_P050) in Human HepG2 using Western Blot

    INTS4 Antibody - C-terminal region (ARP51695_P050)

    Protein Name:Integrator complex subunit 4
    Catalog #:ARP51695_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  •  
    PAX2 Antibody - middle region (ARP31220_P050) in Human MCF7 using Western Blot

    PAX2 Antibody - middle region (ARP31220_P050)

    Protein Name:Paired box protein Pax-2 Ensembl ENSP00000452527
    Catalog #:ARP31220_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Sheep, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    DHX16 antibody - N-terminal region (ARP36356_P050) in Human PANC1 using Western Blot

    DHX16 antibody - N-terminal region (ARP36356_P050)

    Protein Name:cDNA FLJ53577, highly similar to pre-mRNA-splicing factor ATP-dependentRNA helicase DHX16 (EC 3.6.1.-) EMBL BAG63940.1
    Catalog #:ARP36356_P050
    Type: pAb
    Reacts with: Cow, Dog, Goat, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Yeast, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    DUX4L4 Antibody - N-terminal region (ARP70161_P050) in Human ACHN using Western Blot

    DUX1 Antibody - N-terminal region (ARP70161_P050)

    Protein Name:double homeobox protein 1
    Catalog #:ARP70161_P050
    Type: pAb
    Reacts with: Human, Pig, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    NADK antibody - C-terminal region (ARP64835_P050) in Human Fetal Kidney using Western Blot

    NADK antibody - C-terminal region (ARP64835_P050)

    Protein Name:NAD kinase Ensembl ENSP00000339727
    Catalog #:ARP64835_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    HMGN3 antibody - middle region (ARP61955_P050) in Human 721_B using Western Blot

    HMGN3 antibody - middle region (ARP61955_P050)

    Protein Name:High mobility group nucleosome-binding domain-containing protein 3
    Catalog #:ARP61955_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    SRGN antibody - N-terminal region (ARP40415_P050) in Human Jurkat using Western Blot

    SRGN antibody - N-terminal region (ARP40415_P050)

    Protein Name:Serglycin
    Catalog #:ARP40415_P050
    Type: pAb
    Reacts with: Human, Mouse, Rabbit, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    DAXX Antibody - C-terminal region (ARP60158_P050) in Human HepG2 using Western Blot

    DAXX Antibody - C-terminal region (ARP60158_P050)

    Protein Name:Death domain-associated protein 6
    Catalog #:ARP60158_P050
    Type: pAb
    Reacts with: Dog, Horse, Human, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    ASCL1 Antibody - N-terminal region (ARP30892_P050) in Human COLO205 using Western Blot

    ASCL1 Antibody - N-terminal region (ARP30892_P050)

    Protein Name:Achaete-scute homolog 1
    Catalog #:ARP30892_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Human, Mouse, Rabbit, Rat, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    Igfbp5 antibody - middle region (ARP54337_P050) in Mouse Pancreas using Western Blot

    Igfbp5 antibody - middle region (ARP54337_P050)

    Protein Name:Insulin-like growth factor binding protein 5, isoform CRA_a EMBL EDL00294.1
    Catalog #:ARP54337_P050
    Type: pAb
    Reacts with: Cow, Dog, Goat, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat, Sheep
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00

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Showing 631 - 660 of 4219