Transcription factors are proteins that regulate gene expression by binding to DNA via one or more DNA-binding domains. This binding is achieved via a combination of electrostatic and van der waals forces and can occur at many closely-related sequences flanking different genes. Once bound to DNA directly or as part of a complex, they can promote or inhibit RNA polymerase recruitment, thereby acting as activators or repressors, respectively. Alternatively, transcription factors can act to recruit coactivators and corepressors or to catalyze histone acetylation and deacetylation. Transcription factors can function downstream of signaling cascades triggered by biological or environmental (ex. hypoxia, hyperthermia) stimuli to alter the expression of target genes. Ligand binding is necessary to activate some transcription factors as this can cause nuclear translocation and changes in the binding affinities for DNA and cofactors. During development, various stimuli can cause transcription factors to up- or down-regulate expression of specific genes at distinct time points to ensure proper development. Transcription factors can function as oncogenes or tumor suppressors and have thus been linked to various cancers. Accordingly, some therapeutic approaches in cancer therapy involve targeting transcription factor families^[1].

^{1. Darnell JE Jr. 2002. Transcription factors as targets for cancer therapy. Nat Rev Cancer. Oct;2(10):740-9.}

Transcription Factor Antibodies Top 20 Showcase

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CENPM Antibody	CENPN Antibody	TP53 Antibody	STAT3 Antibody	TGFB1 Antibody
PAX7 Antibody	CYP1A1 Antibody	SOX10 Antibody	HMOX1 Antibody	GATA3 Antibody
HES1 Antibody	ATF4 Antibody	CD36 Antibody	TFAM Antibody	OLIG2 N term Antibody
GATA6 Antibody	MMP9 Antibody	MMP2 Antibody	KDR Antibody	MUC1 Antibody