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Transcription Factor Antibodies

Transcription factors are proteins that regulate gene expression by binding to DNA via one or more DNA-binding domains. This binding is achieved via a combination of electrostatic and van der waals forces and can occur at many closely-related sequences flanking different genes. Once bound to DNA directly or as part of a complex, they can promote or inhibit RNA polymerase recruitment, thereby acting as activators or repressors, respectively. Alternatively, transcription factors can act to recruit coactivators and corepressors or to catalyze histone acetylation and deacetylation. Transcription factors can function downstream of signaling cascades triggered by biological or environmental (ex. hypoxia, hyperthermia) stimuli to alter the expression of target genes. Ligand binding is necessary to activate some transcription factors as this can cause nuclear translocation and changes in the binding affinities for DNA and cofactors. During development, various stimuli can cause transcription factors to up- or down-regulate expression of specific genes at distinct time points to ensure proper development. Transcription factors can function as oncogenes or tumor suppressors and have thus been linked to various cancers. Accordingly, some therapeutic approaches in cancer therapy involve targeting transcription factor families[1].

1. Darnell JE Jr. 2002. Transcription factors as targets for cancer therapy. Nat Rev Cancer. Oct;2(10):740-9.

Transcription Factor Antibodies Top 20 Showcase

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Transcription Factors are involved in transcriptional regulation in the form of up regulation or down regulation acting as either repressors or activators of transcription. We have manufactured more than 3000 antibody products covering almost every known human and mouse transcription factors.

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  • TRIAL 
    Sp7 Antibody - N-terminal region (ARP37446_P050) in Rat Testis using Western Blot

    Sp7 Antibody - N-terminal region (ARP37446_P050)

    Protein Name:Specificity protein 7 beta EMBL DAA01456.1
    Catalog #:ARP37446_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    NOS1AP antibody - C-terminal region (ARP64061_P050) in Human HeLa using Western Blot

    NOS1AP antibody - C-terminal region (ARP64061_P050)

    Protein Name:Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein
    Catalog #:ARP64061_P050
    Type: pAb
    Reacts with: Cow, Guinea Pig, Horse, Human, Mouse, Rat, Yeast, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    Trerf1 antibody - N-terminal region (ARP39765_P050) in Mouse Intestine using Western Blot

    Trerf1 antibody - N-terminal region (ARP39765_P050)

    Protein Name:Transcriptional-regulating factor 1
    Catalog #:ARP39765_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    Naprt1 antibody - N-terminal region (ARP62879_P050) in Mouse Kidney using Western Blot

    Naprt1 antibody - N-terminal region (ARP62879_P050)

    Protein Name:Nicotinate phosphoribosyltransferase
    Catalog #:ARP62879_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rat, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    MED6 Antibody - N-terminal region (ARP38627_P050) in Human Esophagus Tumor using Western Blot

    MED6 Antibody - N-terminal region (ARP38627_P050)

    Protein Name:Mediator of RNA polymerase II transcription subunit 6
    Catalog #:ARP38627_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Yeast, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    PACS1 antibody - C-terminal region (ARP64805_P050) in Human Placenta using Western Blot

    PACS1 antibody - C-terminal region (ARP64805_P050)

    Protein Name:Phosphofurin acidic cluster sorting protein 1
    Catalog #:ARP64805_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    Pax8 antibody - C-terminal region (ARP34180_P050) in Mouse Pancreas using Western Blot
    PAX8 antibody - C-terminal region (ARP34180_P050) in human thyroid tissue using Immunohistochemistry

    Pax8 antibody - C-terminal region (ARP34180_P050)

    Protein Name:Paired box protein Pax-8
    Catalog #:ARP34180_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat
    Application: WB, IHC
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    Pepd antibody - middle region (ARP56087_P050) in Mouse Small Intestine using Western Blot

    Pepd antibody - middle region (ARP56087_P050)

    Protein Name:Xaa-Pro dipeptidase
    Catalog #:ARP56087_P050
    Type: pAb
    Reacts with: Cow, Dog, Goat, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    CALR Antibody - N-terminal region (ARP58123_P050) in Human 721_B using Western Blot
    CALR Antibody - N-terminal region (ARP58123_P050) in human heart using Immunohistochemistry

    CALR Antibody - N-terminal region (ARP58123_P050)

    Protein Name:Calreticulin
    Catalog #:ARP58123_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat, Zebrafish
    Application: WB, IHC
    Product Size: 100 ul
    Price (USD): $289.00

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Showing 451 - 480 of 4223