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Now Offering Over 85,203 Antibodies & 34,301 Antigens!

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Transcription Factor Antibodies

Transcription factors are proteins that regulate gene expression by binding to DNA via one or more DNA-binding domains. This binding is achieved via a combination of electrostatic and van der waals forces and can occur at many closely-related sequences flanking different genes. Once bound to DNA directly or as part of a complex, they can promote or inhibit RNA polymerase recruitment, thereby acting as activators or repressors, respectively. Alternatively, transcription factors can act to recruit coactivators and corepressors or to catalyze histone acetylation and deacetylation. Transcription factors can function downstream of signaling cascades triggered by biological or environmental (ex. hypoxia, hyperthermia) stimuli to alter the expression of target genes. Ligand binding is necessary to activate some transcription factors as this can cause nuclear translocation and changes in the binding affinities for DNA and cofactors. During development, various stimuli can cause transcription factors to up- or down-regulate expression of specific genes at distinct time points to ensure proper development. Transcription factors can function as oncogenes or tumor suppressors and have thus been linked to various cancers. Accordingly, some therapeutic approaches in cancer therapy involve targeting transcription factor families[1].

1. Darnell JE Jr. 2002. Transcription factors as targets for cancer therapy. Nat Rev Cancer. Oct;2(10):740-9.

Transcription Factor Antibodies Top 20 Showcase

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Transcription Factors are involved in transcriptional regulation in the form of up regulation or down regulation acting as either repressors or activators of transcription. We have manufactured more than 3000 antibody products covering almost every known human and mouse transcription factors.

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  • TRIAL 

    PSMD4 Antibody - C-terminal region (ARP58059_P050)

    Protein Name:26S proteasome non-ATPase regulatory subunit 4
    Catalog #:ARP58059_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Sheep, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    P53 Antibody (ARP30310_P050) in Human Fetal Kidney using Western Blot

    P53 Antibody - C-terminal region (ARP30310_P050)

    Protein Name:Cellular tumor antigen p53
    Catalog #:ARP30310_P050
    Type: pAb
    Reacts with: Dog, Human, Pig, Rabbit, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    PAX3 Antibody (ARP32063_P050) in Human HepG2 Whole Cell using Western Blot

    PAX3 Antibody - C-terminal region (ARP32063_P050)

    Protein Name:Paired box protein Pax-3
    Catalog #:ARP32063_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    PTRF Antibody - C-terminal region (ARP72430_P050) in Human MCF7 using Western Blot

    PTRF Antibody - C-terminal region (ARP72430_P050)

    Protein Name:
    Catalog #:ARP72430_P050
    Type: pAb
    Reacts with: Human
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    PCGF3 antibody - middle region (ARP34415_T100) in Human Brain using Western Blot

    PCGF3 antibody - middle region (ARP34415_T100)

    Protein Name:Polycomb group RING finger protein 3
    Catalog #:ARP34415_T100
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat, Yeast
    Application: WB
    Product Size: 100 ul
    Price (USD): $229.00
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    PCGF3 antibody - middle region (ARP34416_P050) in Human Raji using Western Blot
    PCGF3 antibody - middle region (ARP34416_P050) in Human Fetal Muscle using Western Blot

    PCGF3 antibody - middle region (ARP34416_P050)

    Protein Name:Polycomb group RING finger protein 3
    Catalog #:ARP34416_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00

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Showing 1 - 30 of 303