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Transcription Factor Antibodies

Transcription factors are proteins that regulate gene expression by binding to DNA via one or more DNA-binding domains. This binding is achieved via a combination of electrostatic and van der waals forces and can occur at many closely-related sequences flanking different genes. Once bound to DNA directly or as part of a complex, they can promote or inhibit RNA polymerase recruitment, thereby acting as activators or repressors, respectively. Alternatively, transcription factors can act to recruit coactivators and corepressors or to catalyze histone acetylation and deacetylation. Transcription factors can function downstream of signaling cascades triggered by biological or environmental (ex. hypoxia, hyperthermia) stimuli to alter the expression of target genes. Ligand binding is necessary to activate some transcription factors as this can cause nuclear translocation and changes in the binding affinities for DNA and cofactors. During development, various stimuli can cause transcription factors to up- or down-regulate expression of specific genes at distinct time points to ensure proper development. Transcription factors can function as oncogenes or tumor suppressors and have thus been linked to various cancers. Accordingly, some therapeutic approaches in cancer therapy involve targeting transcription factor families[1].

1. Darnell JE Jr. 2002. Transcription factors as targets for cancer therapy. Nat Rev Cancer. Oct;2(10):740-9.

Transcription Factor Antibodies Top 20 Showcase

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Transcription Factors are involved in transcriptional regulation in the form of up regulation or down regulation acting as either repressors or activators of transcription. We have manufactured more than 3000 antibody products covering almost every known human and mouse transcription factors.

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Showing 1 - 30 of 284
  Type Catalog # Product Product Images Price (USD)
  pAb ARP72562_P050 PROX1 Antibody - middle region (ARP72562_P050)
Reacts with
Human
Application
WB
$289.00
  pAb ARP72403_P050 PCNA Antibody - N-terminal region (ARP72403_P050)
Reacts with
Human
Application
WB
$289.00
  pAb ARP33217_P050 PRD12 Antibody - C-terminal region (ARP33217_P050)
Reacts with
Human
Application
WB
$289.00
  pAb ARP38063_P050 PAX6 Antibody - C-terminal region (ARP38063_P050)
Reacts with
Human
Application
WB
$289.00
  pAb ARP38557_P050 PA24B Antibody - C-terminal region (ARP38557_P050)
Reacts with
Human
Application
WB
$289.00
  pAb ARP58059_P050 PSMD4 Antibody - C-terminal region (ARP58059_P050)
Reacts with
Human, Horse, Rabbit, Dog, Rat, Guinea pig, Sheep, Bovine, Mouse, Zebrafish
Application
WB
$289.00
  pAb ARP72430_P050 PTRF Antibody - C-terminal region (ARP72430_P050)
Reacts with
Human
Application
WB
$289.00
  pAb ARP34415_T100 PCGF3 antibody - middle region (ARP34415_T100)
Reacts with
Human, Dog, Rat, Bovine, Pig, Mouse, Rabbit, Horse, Guinea pig, Yeast
Application
WB
$229.00
  pAb ARP34416_P050 PCGF3 antibody - middle region (ARP34416_P050)
Reacts with
Human, Horse, Pig, Dog, Bovine, Rat, Rabbit, Guinea pig, Mouse
Application
WB
$289.00
  pAb ARP36965_T100 PTRF antibody - middle region (ARP36965_T100)
Reacts with
Mouse, Horse, Rat, Dog, Human, Bovine, Rabbit
Application
IHC, WB
$229.00
  pAb ARP39560_P050 Prrx1 Antibody - C-terminal region (ARP39560_P050)
Reacts with
Bovine, Dog, Rabbit, Rat, Guinea pig, Human, Mouse, Zebrafish
Application
WB
$289.00
  pAb ARP49346_P050 PCDHA11 antibody - N-terminal region (ARP49346_P050)
Reacts with
Human, Mouse, Bovine, Horse, Rat, Rabbit, Pig, Guinea pig
Application
WB
$289.00
  pAb ARP62310_P050 PRSS58 antibody - C-terminal region (ARP62310_P050)
Reacts with
Pig, Bovine, Human, Rabbit, Rat, Guinea pig, Dog, Horse, Mouse
Application
WB
$289.00
  pAb ARP37463_P050 Ptges2 Antibody - N-terminal region (ARP37463_P050)
Reacts with
Mouse, Human, Rat
Application
WB
$289.00
  pAb ARP52904_P050 Paqr4 antibody - C-terminal region (ARP52904_P050)
Reacts with
Bovine, Human, Dog, Rat, Guinea pig, Mouse, Goat, Rabbit
Application
WB
$289.00
  pAb ARP48087_P050 PAX8 Antibody - middle region (ARP48087_P050)
Reacts with
Human, Rat, Bovine, Horse, Rabbit, Guinea pig, Dog, Mouse
Application
WB
$289.00
  pAb ARP56638_P050 Prkab2 antibody - N-terminal region (ARP56638_P050)
Reacts with
Mouse, Bovine, Horse, Rabbit, Rat, Guinea pig, Human, Dog
Application
WB
$289.00
  pAb ARP63809_P050 PEX14 Antibody - C-terminal region (ARP63809_P050)
Reacts with
Dog, Pig, Human, Horse, Rat, Guinea pig, Mouse, Zebrafish
Application
WB
$289.00
  pAb ARP63674_P050 PGM2 antibody - C-terminal region (ARP63674_P050)
Reacts with
Human, Dog, Pig, Horse, Guinea pig, Mouse, Rabbit, Rat, Zebrafish, Bovine
Application
WB
$289.00
  pAb ARP64806_P050 PACS1 antibody - C-terminal region (ARP64806_P050)
Reacts with
Human, Bovine, Dog, Rat, Pig, Horse, Rabbit, Guinea pig, Mouse
Application
WB
$289.00
  pAb ARP34180_P050 Pax8 antibody - C-terminal region (ARP34180_P050)
Reacts with
Mouse, Rat, Bovine, Horse, Rabbit, Human, Pig, Dog, Guinea pig
Application
WB
$289.00
  pAb ARP33060_P050 Pou3f1 Antibody - C-terminal region (ARP33060_P050)
Reacts with
Bovine, Dog, Pig, Horse, Rabbit, Guinea pig, Rat, Mouse, Human, Zebrafish
Application
WB
$289.00
  pAb ARP56087_P050 Pepd antibody - middle region (ARP56087_P050)
Reacts with
Mouse, Rat, Dog, Pig, Horse, Rabbit, Guinea pig, Human, Bovine, Zebrafish, Goat
Application
WB
$289.00
  pAb ARP31516_P050 Prdm4 Antibody - C-terminal region (ARP31516_P050)
Reacts with
Rabbit, Rat, Human, Dog, Horse, Yeast, Bovine, Pig, Mouse
Application
WB
$289.00
  pAb ARP53839_P050 Pias2 antibody - N-terminal region (ARP53839_P050)
Reacts with
Dog, Rat, Bovine, Horse, Rabbit, Guinea pig, Human, Mouse, Zebrafish
Application
WB
$289.00
  pAb ARP37243_P050 Ptf1a Antibody - N-terminal region (ARP37243_P050)
Reacts with
Mouse, Bovine, Pig, Rat, Human, Horse, Dog
Application
WB
$289.00
  pAb ARP50680_P050 Plekhf2 antibody - N-terminal region (ARP50680_P050)
Reacts with
Mouse, Rat, Rabbit, Human, Bovine, Horse, Guinea pig
Application
WB
$289.00
  pAb ARP39376_P050 PRDM5 Antibody - N-terminal region (ARP39376_P050)
Reacts with
Rat, Mouse, Bovine, Zebrafish, Guinea pig, Human, Horse
Application
WB
$289.00
  pAb ARP50246_P050 Pigu antibody - N-terminal region (ARP50246_P050)
Reacts with
Human, Pig, Dog, Bovine, Horse, Rabbit, Rat, Mouse, Zebrafish, Guinea pig
Application
WB
$289.00
  pAb ARP62122_P050 Pitpna antibody - C-terminal region (ARP62122_P050)
Reacts with
Human, Dog, Horse, Rabbit, Rat, Pig, Mouse, Bovine, Zebrafish
Application
WB
$289.00

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Showing 1 - 30 of 284