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Transcription Factor Antibodies

Transcription factors are proteins that regulate gene expression by binding to DNA via one or more DNA-binding domains. This binding is achieved via a combination of electrostatic and van der waals forces and can occur at many closely-related sequences flanking different genes. Once bound to DNA directly or as part of a complex, they can promote or inhibit RNA polymerase recruitment, thereby acting as activators or repressors, respectively. Alternatively, transcription factors can act to recruit coactivators and corepressors or to catalyze histone acetylation and deacetylation. Transcription factors can function downstream of signaling cascades triggered by biological or environmental (ex. hypoxia, hyperthermia) stimuli to alter the expression of target genes. Ligand binding is necessary to activate some transcription factors as this can cause nuclear translocation and changes in the binding affinities for DNA and cofactors. During development, various stimuli can cause transcription factors to up- or down-regulate expression of specific genes at distinct time points to ensure proper development. Transcription factors can function as oncogenes or tumor suppressors and have thus been linked to various cancers. Accordingly, some therapeutic approaches in cancer therapy involve targeting transcription factor families[1].

1. Darnell JE Jr. 2002. Transcription factors as targets for cancer therapy. Nat Rev Cancer. Oct;2(10):740-9.

Transcription Factor Antibodies Top 20 Showcase

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Transcription Factors are involved in transcriptional regulation in the form of up regulation or down regulation acting as either repressors or activators of transcription. We have manufactured more than 3000 antibody products covering almost every known human and mouse transcription factors.

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  • TRIAL 
    MORF4L2 antibody - N-terminal region (ARP33720_T100) in Human HepG2 using Western Blot
    MORF4L2 antibody - N-terminal region (ARP33720_T100) in Human kidney using Immunohistochemistry

    MORF4L2 antibody - N-terminal region (ARP33720_T100)

    Protein Name:Mortality factor 4-like protein 2
    Catalog #:ARP33720_T100
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat, Yeast
    Application: IHC, WB
    Product Size: 100 ul
    Price (USD): $229.00
  • TRIAL 
    Mlxipl Antibody - N-terminal region (ARP37299_P050) in Mouse Thymus using Western Blot

    Mlxipl Antibody - N-terminal region (ARP37299_P050)

    Protein Name:Carbohydrate-responsive element-binding protein
    Catalog #:ARP37299_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    Mfng antibody - middle region (ARP45395_P050) in Mouse Thymus using Western Blot

    Mfng antibody - middle region (ARP45395_P050)

    Protein Name:Beta-1,3-N-acetylglucosaminyltransferase manic fringe
    Catalog #:ARP45395_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    MXD3 Antibody - C-terminal region (ARP39664_P050) in Human Esophagus Tumor using Western Blot

    MXD3 Antibody - C-terminal region (ARP39664_P050)

    Protein Name:Max dimerization protein 3
    Catalog #:ARP39664_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    Mgat5b antibody - C-terminal region (ARP49192_P050) in Rat Muscle using Western Blot

    Mgat5b antibody - C-terminal region (ARP49192_P050)

    Protein Name:Mannoside acetylglucosaminyltransferase 5, isoenzyme B (Predicted) EMBL EDM06709.1
    Catalog #:ARP49192_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rat, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    MED19 Antibody - middle region (ARP55596_P050) in Human Jurkat using Western Blot
    MED19 Antibody - middle region (ARP55596_P050) in HCT116 using CHIP

    MED19 Antibody - middle region (ARP55596_P050)

    Protein Name:Mediator of RNA polymerase II transcription subunit 19
    Catalog #:ARP55596_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
    Application: WB, CHIP
    Product Size: 100 ul
    Price (USD): $289.00

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