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Transcription Factor Antibodies

Transcription factors are proteins that regulate gene expression by binding to DNA via one or more DNA-binding domains. This binding is achieved via a combination of electrostatic and van der waals forces and can occur at many closely-related sequences flanking different genes. Once bound to DNA directly or as part of a complex, they can promote or inhibit RNA polymerase recruitment, thereby acting as activators or repressors, respectively. Alternatively, transcription factors can act to recruit coactivators and corepressors or to catalyze histone acetylation and deacetylation. Transcription factors can function downstream of signaling cascades triggered by biological or environmental (ex. hypoxia, hyperthermia) stimuli to alter the expression of target genes. Ligand binding is necessary to activate some transcription factors as this can cause nuclear translocation and changes in the binding affinities for DNA and cofactors. During development, various stimuli can cause transcription factors to up- or down-regulate expression of specific genes at distinct time points to ensure proper development. Transcription factors can function as oncogenes or tumor suppressors and have thus been linked to various cancers. Accordingly, some therapeutic approaches in cancer therapy involve targeting transcription factor families[1].

1. Darnell JE Jr. 2002. Transcription factors as targets for cancer therapy. Nat Rev Cancer. Oct;2(10):740-9.

Transcription Factor Antibodies Top 20 Showcase

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Transcription Factors are involved in transcriptional regulation in the form of up regulation or down regulation acting as either repressors or activators of transcription. We have manufactured more than 3000 antibody products covering almost every known human and mouse transcription factors.

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  • TRIAL 
    MED6 Antibody - N-terminal region (ARP38627_P050) in Human Esophagus Tumor using Western Blot

    MED6 Antibody - N-terminal region (ARP38627_P050)

    Protein Name:Mediator of RNA polymerase II transcription subunit 6
    Catalog #:ARP38627_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Yeast, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    MSR1 antibody - N-terminal region (ARP63579_P050) in Human Fetal liver using Western Blot

    MSR1 antibody - N-terminal region (ARP63579_P050)

    Protein Name:Macrophage scavenger receptor types I and II
    Catalog #:ARP63579_P050
    Type: pAb
    Reacts with: Cow, Dog, Horse, Human, Pig
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    MGC4618 antibody - N-terminal region (ARP34360_T100) in Human HepG2 using Western Blot

    MGC4618 antibody - N-terminal region (ARP34360_T100)

    Protein Name:Transmembrane protein 175
    Catalog #:ARP34360_T100
    Type: pAb
    Reacts with: Dog, Guinea Pig, Horse, Human, Mouse, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $229.00
  • TRIAL 
    Msn antibody - C-terminal region (ARP63015_P050) in Mouse Liver using Western Blot
    MSN antibody - C-terminal region (ARP63015_P050) in human liver tissue using Immunohistochemistry

    Msn antibody - C-terminal region (ARP63015_P050)

    Protein Name:Putative uncharacterized protein EMBL BAE34156.1
    Catalog #:ARP63015_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Yeast, Zebrafish
    Application: WB, IHC
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    MID1 Antibody - N-terminal region (ARP58031_P050) in Human  Transfected 293T using Western Blot

    MID1 Antibody - N-terminal region (ARP58031_P050)

    Protein Name:Midline-1
    Catalog #:ARP58031_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    MRGPRX4 antibody - C-terminal region (ARP59927_P050) in Human COLO205 using Western Blot

    MRGPRX4 antibody - C-terminal region (ARP59927_P050)

    Protein Name:Mas-related G-protein coupled receptor member X4
    Catalog #:ARP59927_P050
    Type: pAb
    Reacts with: Human, Mouse, Rabbit
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00

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Showing 1 - 30 of 234