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Transcription Factor Antibodies

Transcription factors are proteins that regulate gene expression by binding to DNA via one or more DNA-binding domains. This binding is achieved via a combination of electrostatic and van der waals forces and can occur at many closely-related sequences flanking different genes. Once bound to DNA directly or as part of a complex, they can promote or inhibit RNA polymerase recruitment, thereby acting as activators or repressors, respectively. Alternatively, transcription factors can act to recruit coactivators and corepressors or to catalyze histone acetylation and deacetylation. Transcription factors can function downstream of signaling cascades triggered by biological or environmental (ex. hypoxia, hyperthermia) stimuli to alter the expression of target genes. Ligand binding is necessary to activate some transcription factors as this can cause nuclear translocation and changes in the binding affinities for DNA and cofactors. During development, various stimuli can cause transcription factors to up- or down-regulate expression of specific genes at distinct time points to ensure proper development. Transcription factors can function as oncogenes or tumor suppressors and have thus been linked to various cancers. Accordingly, some therapeutic approaches in cancer therapy involve targeting transcription factor families[1].

1. Darnell JE Jr. 2002. Transcription factors as targets for cancer therapy. Nat Rev Cancer. Oct;2(10):740-9.

Transcription Factor Antibodies Top 20 Showcase

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Transcription Factors are involved in transcriptional regulation in the form of up regulation or down regulation acting as either repressors or activators of transcription. We have manufactured more than 3000 antibody products covering almost every known human and mouse transcription factors.

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  • TRIAL 
    MORF4L2 antibody - N-terminal region (ARP33720_T100) in Human HepG2 using Western Blot
    MORF4L2 antibody - N-terminal region (ARP33720_T100) in Human kidney using Immunohistochemistry

    MORF4L2 antibody - N-terminal region (ARP33720_T100)

    Protein Name:Mortality factor 4-like protein 2
    Catalog #:ARP33720_T100
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat, Yeast
    Application: IHC, WB
    Product Size: 100 ul
    Price (USD): $229.00
  • TRIAL 
    MTERFD3 Antibody - N-terminal region (ARP67185_P050) in Human HepG2 using Western Blot

    MTERFD3 Antibody - N-terminal region (ARP67185_P050)

    Protein Name:mTERF domain-containing protein 3, mitochondrial
    Catalog #:ARP67185_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    MORF4L1 Antibody - C-terminal region (ARP31510_P050) in Human COLO205 using Western Blot

    MORF4L1 Antibody - C-terminal region (ARP31510_P050)

    Protein Name:Mortality factor 4-like protein 1
    Catalog #:ARP31510_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    MED6 Antibody - N-terminal region (ARP38627_P050) in Human Esophagus Tumor using Western Blot

    MED6 Antibody - N-terminal region (ARP38627_P050)

    Protein Name:Mediator of RNA polymerase II transcription subunit 6
    Catalog #:ARP38627_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Yeast, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    MSR1 antibody - N-terminal region (ARP63579_P050) in Human Fetal liver using Western Blot

    MSR1 antibody - N-terminal region (ARP63579_P050)

    Protein Name:Macrophage scavenger receptor types I and II
    Catalog #:ARP63579_P050
    Type: pAb
    Reacts with: Cow, Dog, Horse, Human, Pig
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    MGC4618 antibody - N-terminal region (ARP34360_T100) in Human HepG2 using Western Blot

    MGC4618 antibody - N-terminal region (ARP34360_T100)

    Protein Name:Transmembrane protein 175
    Catalog #:ARP34360_T100
    Type: pAb
    Reacts with: Dog, Guinea Pig, Horse, Human, Mouse, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $229.00

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Showing 1 - 30 of 234