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Now Offering Over 85,203 Antibodies & 34,301 Antigens!

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KCNN3 antibody - C-terminal region (ARP35097_P050)

Description of Target:
Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. KCNN3, a member of the KCNN family of potassium channel genes, encodes a protein that is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits.
Gene Symbol:
KCNN3
Official Gene Full Name:
Potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3
NCBI Gene Id:
3782
Alias Symbols:
SK3; hSK3; SKCA3; KCa2.3
Sample Type Confirmation:

KCNN3 is supported by BioGPS gene expression data to be expressed in Daudi

Tissue Tool:
Find tissues and cell lines supported to express KCNN3.
Protein Accession #:
NP_002240
Nucleotide Accession#:
NM_002249
Swissprot Id:
Q9UGI6
Host:
Rabbit
Clonality:
Polyclonal
Protein Name:
Small conductance calcium-activated potassium channel protein 3
Protein Size (# AA):
736
Molecular Weight:
81kDa
Application:
IHC, WB
Partner Proteins:
CALM1, PRKAG1, UBC
Immunogen:
The immunogen for anti-KCNN3 antibody: synthetic peptide directed towards the C terminal of human KCNN3
Product Format:
Lyophilized powder
Purification:
Affinity Purified
Complete computational species homology data:
KCNN3 antibody - C-terminal region (ARP35097_P050)
Predicted Homology Based on Immunogen Sequence:
Dog: 100%; Pig: 100%; Rat: 100%; Human: 100%; Mouse: 100%; Bovine: 100%; Rabbit: 100%; Guinea pig: 100%; Horse: 93%
Species Reactivity:
Bovine, Dog, Pig, Rabbit, Rat, Guinea pig, Mouse, Human, Horse
Datasheets / Downloads:
Printable datasheet for
anti-KCNN3 antibody
- ARP35097_P050
Peptide Sequence:
Synthetic peptide located within the following region: ITELNDRSEDLEKQIGSLESKLEHLTASFNSLPLLIADTLRQQQQQLLSA
Blocking Peptide:
For anti-KCNN3 antibody is Catalog # AAP35097 (Previous Catalog # AAPP06328)
Key Reference:
Kolski-Andreaco,A., et al., (2004) J. Biol. Chem. 279 (8), 6893-6904
Reconstitution and Storage:
Add 50 ul of distilled water. Final anti-KCNN3 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles.
 
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