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Now Offering Over 85,203 Antibodies & 34,301 Antigens!

Ion Channel Antibodies

Ion channels are a class of membrane-bound proteins that are present on the surface of all cells as well as on intracellular organelles. Ion channels typically function by creating and maintaining an ion gradient across either cellular or organelle membranes. These channels, comprised of a variety of different protein subunits, contain a pore that can be as narrow as a single atom, allowing for precise control of ion passage.

Ion channels play a critical role in the proper functioning of the human nervous system. Voltage-gated ion channels are present on all neurons and it is the voltage gradient created and maintained by these channels that permits signal propagation; a change in the voltage across the membrane can cause the channel to open or close.

Ion channels, such as those that are present at neuronal synapses, can also be ligand-gated in which the binding of a specific ligand will result in a conformational change in the ion channel resulting in pore opening. In addition to voltage- and ligand-activated ion channels, ion channels can also be activated by heat, temperature, or mechanical stress.

Ion channels have a variety of biological functions, including roles in neuronal signal transmission, muscle contraction, T-cell activation, and insulin release from beta cells. Dysfunctional ion channel activity is the basis of many human diseases. For instance, cystic fibrosis is a result of a genetic mutation in the CFTR gene, which encodes a protein component of a chloride ion channel[1]. Specific natural or synthetic toxins can also affect the functional ability of ion channels; the puffer fish produces tetrodotoxin (TTX), which inhibits the function of sodium channels and can cause respiratory paralysis and death.

1. Rogan, et al. 2011. Cystic fibrosis transmembrane conductance regulator intracellular processing, trafficking, and opportunities for mutation-specific treatment. Chest. 139(6):1480-90.

Ion channels are gated, ion-selective glycoproteins that traverse membranes. The stimulus for channel gating can be a membrane potential, drug, transmitter, cytoplasmic messenger, or a mechanical deformation. We have manufactured products for ~200 human ion channel proteins.

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Showing 211 - 240 of 330
  Type Catalog # Product Product Images Price (USD)
  pAb ARP35408_P050 CHRFAM7A antibody - middle region (ARP35408_P050)
Reacts with
Dog, Rat, Guinea pig, Human, Mouse, Bovine, Horse, Rabbit, Zebrafish
Application
WB
$289.00
  pAb ARP36736_P050 KCTD4 antibody - middle region (ARP36736_P050)
Reacts with
Bovine, Rat, Dog, Horse, Rabbit, Guinea pig, Human, Mouse
Application
WB
$289.00
  pAb ARP44295_P050 Aqp2 antibody - middle region (ARP44295_P050)
Reacts with
Human, Rat, Guinea pig, Dog, Mouse, Horse, Sheep, Bovine
Application
WB
$289.00
  pAb AVARP13100_P050 CHRNA6 Antibody - N-terminal region (AVARP13100_P050)
Reacts with
Dog, Human, Mouse, Rat
Application
WB
$289.00
  pAb ARP35376_P050 BTBD10 antibody - N-terminal region (ARP35376_P050)
Reacts with
Human, Horse, Rabbit, Rat, Guinea pig, Dog, Mouse
Application
WB
$289.00
  pAb ARP35365_P050 KCNA7 antibody - C-terminal region (ARP35365_P050)
Reacts with
Human, Rat, Pig, Guinea pig, Mouse, Dog, Bovine
Application
WB
$289.00
  pAb ARP35422_P050 KCTD7 antibody - N-terminal region (ARP35422_P050)
Reacts with
Bovine, Rat, Human, Dog, Pig, Mouse, Horse, Rabbit
Application
WB
$289.00
  pAb ARP35594_P050 CACNB2 antibody - middle region (ARP35594_P050)
Reacts with
Human, Mouse, Pig, Horse, Bovine, Rat, Dog, Rabbit, Guinea pig, Zebrafish
Application
WB
$289.00
  pAb ARP35227_P050 SCN8A antibody - middle region (ARP35227_P050)
Reacts with
Dog, Rat, Bovine, Pig, Mouse, Horse, Human, Rabbit, Guinea pig
Application
WB
$289.00
  pAb ARP35512_P050 P2RX4 antibody - N-terminal region (ARP35512_P050)
Reacts with
Human, Mouse, Dog, Pig, Rabbit, Rat, Zebrafish, Guinea pig, Bovine
Application
WB
$289.00
  pAb ARP53102_P050 OSTalpha antibody - middle region (ARP53102_P050)
Reacts with
Dog, Horse, Human, Rat, Rabbit, Guinea pig, Bovine, Mouse
Application
WB
$289.00
  pAb ARP35580_P050 CACNB1 antibody - middle region (ARP35580_P050)
Reacts with
Mouse, Zebrafish, Human, Rat, Dog, Bovine, Pig, Horse, Rabbit, Guinea pig
Application
WB
$289.00
  pAb ARP35209_P050 P2RX2 antibody - N-terminal region (ARP35209_P050)
Reacts with
Human
Application
WB
$289.00
  pAb ARP35502_P050 KCNRG antibody - middle region (ARP35502_P050)
Reacts with
Human, Dog, Pig, Horse, Rabbit, Bovine
Application
WB
$289.00
  pAb AVARP13003_P050 GLRA1 antibody - middle region (AVARP13003_P050)
Reacts with
Bovine, Dog, Guinea pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
Application
WB
$289.00
  pAb ARP46562_P050 FXYD1 antibody - N-terminal region (ARP46562_P050)
Reacts with
Human, Dog, Horse, Pig, Bovine, Guinea pig, Rabbit, Rat
Application
WB
$289.00
  pAb ARP34983_P050 GABRA5 antibody - middle region (ARP34983_P050)
Reacts with
Human, Horse, Rabbit, Dog, Pig, Rat, Guinea pig, Bovine, Mouse
Application
WB
$289.00
  pAb ARP45640_P050 NR6A1 antibody - middle region (ARP45640_P050)
Reacts with
Pig, Sheep, Rat, Human, Bovine, Dog, Horse, Rabbit, Guinea pig, Mouse
Application
WB
$289.00
  pAb ARP35566_P050 CACNA1G antibody - C - terminal region (ARP35566_P050)
Reacts with
Human, Dog, Horse, Rabbit, Mouse, Rat, Bovine, Pig, Guinea pig
Application
IHC, WB
$289.00
  pAb ARP35180_P050 VDAC3 antibody - N-terminal region (ARP35180_P050)
Reacts with
Bovine, Dog, Human, Pig, Horse, Goat, Rat, Guinea pig, Mouse, Rabbit, Zebrafish
Application
IHC, WB
$289.00
  pAb ARP35490_P050 KCNIP2 antibody - middle region (ARP35490_P050)
Reacts with
Pig, Human, Bovine, Rat, Mouse, Dog, Horse, Rabbit, Guinea pig, Zebrafish
Application
WB
$289.00
  pAb ARP37688_P050 KCNH3 antibody - middle region (ARP37688_P050)
Reacts with
Human, Mouse, Rabbit, Rat, Bovine, Dog, Horse, Guinea pig
Application
WB
$289.00
  pAb ARP35298_P050 ACCN2 antibody - N-terminal region (ARP35298_P050)
Reacts with
Human, Horse, Rabbit, Guinea pig, Dog, Rat, Mouse, Bovine
Application
WB
$289.00
  pAb ARP34965_P050 CHRNA4 antibody - N-terminal region (ARP34965_P050)
Reacts with
Mouse, Guinea pig, Human, Rat, Dog, Zebrafish, Bovine, Horse, Rabbit
Application
WB
$289.00
  pAb ARP57727_P050 NDNL2 antibody - middle region (ARP57727_P050)
Reacts with
Pig, Horse, Rabbit, Guinea pig, Rat, Mouse, Human, Bovine
Application
WB
$289.00
  pAb ARP35537_P050 ACCN1 antibody - middle region (ARP35537_P050)
Reacts with
Human, Mouse, Horse, Bovine, Dog, Rabbit, Rat, Zebrafish
Application
WB
$289.00
  pAb ARP35167_P050 KCNJ4 antibody - middle region (ARP35167_P050)
Reacts with
Dog, Pig, Rabbit, Rat, Guinea pig, Human, Mouse
Application
WB
$289.00
  pAb ARP35480_P050 KCNH6 antibody - middle region (ARP35480_P050)
Reacts with
Human, Guinea pig, Bovine, Dog, Horse, Rabbit, Mouse, Rat, Zebrafish
Application
WB
$289.00
  pAb ARP35467_P050 KCND3 antibody - middle region (ARP35467_P050)
Reacts with
Pig, Mouse, Human, Rat, Bovine, Horse, Rabbit, Guinea pig, Dog
Application
WB
$289.00
  pAb ARP36776_P050 TRPM3 antibody - N-terminal region (ARP36776_P050)
Reacts with
Human, Zebrafish, Mouse, Rat, Bovine, Dog, Horse, Rabbit, Guinea pig
Application
WB
$289.00

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Showing 211 - 240 of 330