Ion Channel Antibodies

Ion channels are a class of membrane-bound proteins that are present on the surface of all cells as well as on intracellular organelles. Ion channels typically function by creating and maintaining an ion gradient across either cellular or organelle membranes. These channels, comprised of a variety of different protein subunits, contain a pore that can be as narrow as a single atom, allowing for precise control of ion passage.

Ion channels play a critical role in the proper functioning of the human nervous system. Voltage-gated ion channels are present on all neurons and it is the voltage gradient created and maintained by these channels that permits signal propagation; a change in the voltage across the membrane can cause the channel to open or close.

Ion channels, such as those that are present at neuronal synapses, can also be ligand-gated in which the binding of a specific ligand will result in a conformational change in the ion channel resulting in pore opening. In addition to voltage- and ligand-activated ion channels, ion channels can also be activated by heat, temperature, or mechanical stress.

Ion channels have a variety of biological functions, including roles in neuronal signal transmission, muscle contraction, T-cell activation, and insulin release from beta cells. Dysfunctional ion channel activity is the basis of many human diseases. For instance, cystic fibrosis is a result of a genetic mutation in the CFTR gene, which encodes a protein component of a chloride ion channel^[1]. Specific natural or synthetic toxins can also affect the functional ability of ion channels; the puffer fish produces tetrodotoxin (TTX), which inhibits the function of sodium channels and can cause respiratory paralysis and death.

1. Rogan, et al. 2011. Cystic fibrosis transmembrane conductance regulator intracellular processing, trafficking, and opportunities for mutation-specific treatment. Chest. 139(6):1480-90.

Polyclonal Antibody - Ion Channel Family

Ion channels are gated, ion-selective glycoproteins that traverse membranes. The stimulus for channel gating can be a membrane potential, drug, transmitter, cytoplasmic messenger, or a mechanical deformation. We have manufactured products for ~200 human ion channel proteins.

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Type	Catalog #	Product	Product Images	Price (USD)
pAb	ARP36776_P050	TRPM3 antibody - N-terminal region (ARP36776_P050) Reacts with Bovine, Chicken, Dog, Guinea pig, Horse, Human, Mouse, Pig, Rabbit, Rat, Zebrafish Application WB	Human Jurkat	$289.00
pAb	ARP37668_P050	CACNG1 antibody - N-terminal region (ARP37668_P050) Reacts with Mouse, Rat, Dog Application WB	Human Jurkat	$289.00
pAb	ARP37674_P050	GRIK5 Antibody (ARP37674_P050 ) Reacts with Bovine, Dog, Guinea pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish Application WB, IHC	Human Jurkat	$289.00
pAb	ARP37678_P050	KCNAB2 antibody - middle region (ARP37678_P050) Reacts with African clawed frog, Bovine, Chicken, Dog, Horse, Human, Mouse, Rabbit Application WB, IHC	Human Jurkat Human Jurkat Human Kidney	$289.00
pAb	ARP37679_P050	KCNK5 antibody - C-terminal region (ARP37679_P050) Reacts with Bovine, Guinea pig, Horse, Human, Dog, Pig, Rabbit Application WB	Human HepG2	$289.00
pAb	ARP37688_P050	KCNH3 antibody - middle region (ARP37688_P050) Reacts with Human, Mouse, Rat, Bovine, Dog, Guinea pig, Horse, Pig Application WB	Human HeLa	$289.00
pAb	ARP37689_P050	TPTE antibody - middle region (ARP37689_P050) Reacts with Human Application WB	Human Lung	$289.00
pAb	ARP37693_P050	KCNV1 antibody - N-terminal region (ARP37693_P050) Reacts with Human, Mouse, Rabbit, Rat, Bovine, Dog, Horse Application WB	Human 293T	$289.00
pAb	ARP37698_P050	MCOLN3 antibody - middle region (ARP37698_P050) Reacts with Dog, Human, Pig, Rat, Bovine, Mouse, Horse, Chicken Application WB	Human HepG2	$289.00
pAb	ARP37699_P050	SCN3B antibody - N-terminal region (ARP37699_P050) Reacts with Bovine, Human, Mouse, Rabbit, Rat, Dog, Guinea pig Application WB	Human Brain	$289.00
pAb	ARP37700_P050	KCNQ5 antibody - middle region (ARP37700_P050) Reacts with Dog, Human, Mouse, Pig, Rabbit, Bovine, Guinea pig, Chicken, Horse Application WB	Human HT1080	$289.00
pAb	ARP37996_P050	Twist1 antibody - N-terminal region (ARP37996_P050) Reacts with Bovine, Chicken, Horse, Pig, Rat, Zebrafish Application WB	Rat Liver	$289.00
pAb	ARP38384_P050	EED antibody - N-terminal region (ARP38384_P050) Reacts with African clawed frog, Bovine, Chicken, Dog, Guinea pig, Horse, Human, Mouse, Pig, Rabbit, Rat, Zebrafish Application WB	Human HepG2	$289.00
pAb	ARP39226_P050	Zfr antibody - N-terminal region (ARP39226_P050) Reacts with Dog, Human, Mouse, Rabbit, Rat, Zebrafish, African clawed frog Application WB	Mouse Liver	$289.00
pAb	ARP41184_P050	Mrpl21 antibody - middle region (ARP41184_P050) Reacts with Human, Rat, Dog, Mouse, Bovine, Chicken Application WB	Mouse Liver	$289.00
pAb	ARP41373_P050	Insr antibody - middle region (ARP41373_P050) Reacts with Dog, Guinea pig, Horse, Human, Mouse, Rat, Chicken, African clawed frog Application WB	Mouse Pancreas	$289.00
pAb	ARP41403_P050	Serpinc1 antibody - C-terminal region (ARP41403_P050) Reacts with Dog, Horse, Human, Mouse, Bovine, Guinea pig, Pig, Rabbit, Rat, African clawed frog Application WB	Mouse Small Intestine	$289.00
pAb	ARP41756_P050	F2 antibody - N-terminal region (ARP41756_P050) Reacts with Dog, Human, Mouse, Sheep, Rat Application WB	Rat Lung	$289.00
pAb	ARP42079_P050	Rasa1 antibody - C-terminal region (ARP42079_P050) Reacts with Dog, Guinea pig, Horse, Human, Mouse, Pig, Rabbit, Rat, Bovine, Zebrafish Application WB	Mouse Brain	$289.00
pAb	ARP43791_P050	SLC6A3 antibody - N-terminal region (ARP43791_P050) Reacts with Human, Mouse, Horse, Dog, Pig, Zebrafish Application WB	Human HepG2	$289.00
pAb	ARP43806_P050	Slc7a3 antibody - middle region (ARP43806_P050) Reacts with Bovine, Dog, Guinea pig, Horse, Mouse, Pig, Rabbit, Rat, African clawed frog, Chicken Application WB	Mouse Spleen	$289.00
pAb	ARP43870_P050	SLC9A3 antibody - middle region (ARP43870_P050) Reacts with Human, Dog, Mouse, Rat Application WB	Human COLO205	$289.00
pAb	ARP43953_P050	SLC40A1 antibody - middle region (ARP43953_P050) Reacts with Dog, Horse, Human, Mouse, Rabbit, Rat, Bovine, Pig, African clawed frog Application WB		$289.00
pAb	ARP43955_P050	SLC25A44 antibody - middle region (ARP43955_P050) Reacts with African clawed frog, Bovine, Dog, Guinea pig, Human, Mouse, Pig, Rabbit, Rat, Zebrafish Application WB	Human HepG2	$289.00
pAb	ARP44023_P050	SLC25A19 antibody - middle region (ARP44023_P050) Reacts with Human, Mouse, Rat, Dog, Sheep, Pig Application WB	Human HepG2	$289.00
pAb	ARP44052_P050	SLCO5A1 antibody - middle region (ARP44052_P050) Reacts with Bovine, Chicken, Dog, Horse, Human, Mouse, Rat Application WB	Human HepG2	$289.00
pAb	ARP44089_P050	SLC35A4 antibody - middle region (ARP44089_P050) Reacts with Application WB	Human Jurkat	$289.00
pAb	ARP44295_P050	Aqp2 antibody - middle region (ARP44295_P050) Reacts with Dog, Human, Mouse, Rat, Bovine, Horse, Pig, Sheep Application WB	Mouse Heart	$289.00
pAb	ARP44319_P050	HGF antibody - middle region (ARP44319_P050) Reacts with Bovine, Dog, Human, Mouse, Rabbit, Rat, Guinea pig Application WB	Human ACHN	$289.00
pAb	ARP44475_P050	UMODL1 antibody - middle region (ARP44475_P050) Reacts with Human, Bovine, Dog, Rat, Horse, Mouse Application WB	Human HT1080	$289.00

Aviva Systems Biology

Ion Channel Antibodies

Reacts with

Bovine, Chicken, Dog, Guinea pig, Horse, Human, Mouse, Pig, Rabbit, Rat, Zebrafish

Application

WB

Reacts with

Mouse, Rat, Dog

Application

WB

Reacts with

Bovine, Dog, Guinea pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish

Application

WB, IHC

Reacts with

African clawed frog, Bovine, Chicken, Dog, Horse, Human, Mouse, Rabbit

Application

WB, IHC

Reacts with

Bovine, Guinea pig, Horse, Human, Dog, Pig, Rabbit

Application

WB

Reacts with

Human, Mouse, Rat, Bovine, Dog, Guinea pig, Horse, Pig

Application

WB

Reacts with

Human

Application

WB

Reacts with

Human, Mouse, Rabbit, Rat, Bovine, Dog, Horse

Application

WB

Reacts with

Dog, Human, Pig, Rat, Bovine, Mouse, Horse, Chicken

Application

WB

Reacts with

Bovine, Human, Mouse, Rabbit, Rat, Dog, Guinea pig

Application

WB

Reacts with

Dog, Human, Mouse, Pig, Rabbit, Bovine, Guinea pig, Chicken, Horse

Application

WB

Reacts with

Bovine, Chicken, Horse, Pig, Rat, Zebrafish

Application

WB

Reacts with

African clawed frog, Bovine, Chicken, Dog, Guinea pig, Horse, Human, Mouse, Pig, Rabbit, Rat, Zebrafish

Application

WB

Reacts with

Dog, Human, Mouse, Rabbit, Rat, Zebrafish, African clawed frog

Application

WB

Reacts with

Human, Rat, Dog, Mouse, Bovine, Chicken

Application

WB

Reacts with

Dog, Guinea pig, Horse, Human, Mouse, Rat, Chicken, African clawed frog

Application

WB

Reacts with

Dog, Horse, Human, Mouse, Bovine, Guinea pig, Pig, Rabbit, Rat, African clawed frog

Application

WB

Reacts with

Dog, Human, Mouse, Sheep, Rat

Application

WB

Reacts with

Dog, Guinea pig, Horse, Human, Mouse, Pig, Rabbit, Rat, Bovine, Zebrafish

Application

WB

Reacts with

Human, Mouse, Horse, Dog, Pig, Zebrafish