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Now Offering Over 85,203 Antibodies & 34,301 Antigens!

Ion Channel Antibodies

Ion channels are a class of membrane-bound proteins that are present on the surface of all cells as well as on intracellular organelles. Ion channels typically function by creating and maintaining an ion gradient across either cellular or organelle membranes. These channels, comprised of a variety of different protein subunits, contain a pore that can be as narrow as a single atom, allowing for precise control of ion passage.

Ion channels play a critical role in the proper functioning of the human nervous system. Voltage-gated ion channels are present on all neurons and it is the voltage gradient created and maintained by these channels that permits signal propagation; a change in the voltage across the membrane can cause the channel to open or close.

Ion channels, such as those that are present at neuronal synapses, can also be ligand-gated in which the binding of a specific ligand will result in a conformational change in the ion channel resulting in pore opening. In addition to voltage- and ligand-activated ion channels, ion channels can also be activated by heat, temperature, or mechanical stress.

Ion channels have a variety of biological functions, including roles in neuronal signal transmission, muscle contraction, T-cell activation, and insulin release from beta cells. Dysfunctional ion channel activity is the basis of many human diseases. For instance, cystic fibrosis is a result of a genetic mutation in the CFTR gene, which encodes a protein component of a chloride ion channel[1]. Specific natural or synthetic toxins can also affect the functional ability of ion channels; the puffer fish produces tetrodotoxin (TTX), which inhibits the function of sodium channels and can cause respiratory paralysis and death.

1. Rogan, et al. 2011. Cystic fibrosis transmembrane conductance regulator intracellular processing, trafficking, and opportunities for mutation-specific treatment. Chest. 139(6):1480-90.

Ion channels are gated, ion-selective glycoproteins that traverse membranes. The stimulus for channel gating can be a membrane potential, drug, transmitter, cytoplasmic messenger, or a mechanical deformation. We have manufactured products for ~200 human ion channel proteins.

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Showing 211 - 240 of 306
  Type Catalog # Product Product Images Price (USD)
  pAb ARP35101_P050 KCNS1 antibody - N-terminal region (ARP35101_P050)
Reacts with
Human, Bovine, Dog, Rat, Guinea pig, Mouse, Horse, Rabbit, Zebrafish
Application
WB
$289.00
  pAb ARP35398_P050 KCNK10 antibody - N-terminal region (ARP35398_P050)
Reacts with
Human, Dog, Bovine, Pig, Horse, Guinea pig, Mouse, Rabbit, Rat
Application
WB
$289.00
  pAb ARP35457_P050 KCNQ2 antibody - middle region (ARP35457_P050)
Reacts with
Human, Mouse, Rat, Bovine, Dog, Horse, Guinea pig, Zebrafish, Rabbit
Application
IHC, WB
$289.00
  pAb ARP35436_P050 P2RX2 antibody - N-terminal region (ARP35436_P050)
Reacts with
Human, Rat, Guinea pig, Rabbit, Bovine
Application
IHC, WB
$289.00
  pAb ARP36723_P050 KCNK6 antibody - N-terminal region (ARP36723_P050)
Reacts with
Human, Bovine, Pig
Application
WB
$289.00
  pAb ARP35242_P050 TRPM5 antibody - N-terminal region (ARP35242_P050)
Reacts with
Human, Mouse, Dog, Horse, Bovine, Rat, Guinea pig
Application
IHC, WB
$289.00
  pAb ARP33975_P050 KCNB1 antibody - middle region (ARP33975_P050)
Reacts with
Human, Dog, Pig, Bovine, Horse, Rat, Guinea pig, Mouse
Application
WB
$289.00
  pAb ARP59578_P050 BSND antibody - middle region (ARP59578_P050)
Reacts with
Human
Application
WB
$289.00
  pAb ARP35374_P050 TOMM40L antibody - middle region (ARP35374_P050)
Reacts with
Bovine, Human, Dog, Pig, Horse, Rabbit, Rat, Guinea pig, Mouse, Zebrafish
Application
WB
$289.00
  pAb ARP35089_P050 KCNK1 antibody - middle region (ARP35089_P050)
Reacts with
Human, Pig, Horse, Rabbit, Dog, Rat, Guinea pig, Bovine, Mouse
Application
WB
$289.00
  pAb ARP35033_P050 ACCN1 antibody - C-terminal region (ARP35033_P050)
Reacts with
Human, Horse, Dog, Rabbit, Rat, Mouse, Bovine
Application
WB
$289.00
  pAb ARP35172_P050 P2RXL1 antibody - N-terminal region (ARP35172_P050)
Reacts with
Human, Dog, Mouse, Rabbit, Bovine, Pig, Horse, Rat, Guinea pig
Application
WB
$289.00
  pAb ARP35592_P050 CACNB2 antibody - middle region (ARP35592_P050)
Reacts with
Human, Mouse, Rat, Horse, Rabbit, Bovine, Guinea pig, Dog
Application
WB
$289.00
  pAb ARP35226_T100 FXYD5 antibody - middle region (ARP35226_T100)
Reacts with
Human
Application
WB
$229.00
  pAb ARP35511_P050 P2RX5 antibody - N-terminal region (ARP35511_P050)
Reacts with
Human, Rat, Guinea pig, Mouse, Bovine, Rabbit, Dog
Application
WB
$289.00
  pAb ARP35362_P050 KCNH6 antibody - middle region (ARP35362_P050)
Reacts with
Human, Rat
Application
WB
$289.00
  pAb ARP35346_P050 FXYD7 antibody - N-terminal region (ARP35346_P050)
Reacts with
Human, Bovine
Application
WB
$289.00
  pAb ARP34989_P050 GABRB2 antibody - N-terminal region (ARP34989_P050)
Reacts with
Bovine, Zebrafish, Human, Rat, Dog, Horse, Rabbit, Guinea pig, Sheep, Mouse
Application
WB
$289.00
  pAb ARP44023_P050 SLC25A19 antibody - middle region (ARP44023_P050)
Reacts with
Mouse, Rat, Rabbit, Human, Sheep, Dog, Horse, Guinea pig, Bovine, Yeast
Application
WB
$289.00
  pAb ARP35208_P050 P2RX2 antibody - N-terminal region (ARP35208_P050)
Reacts with
Human, Dog, Horse, Rabbit, Pig
Application
WB
$289.00
  pAb ARP35498_P050 KCNIP2 antibody - N-terminal region (ARP35498_P050)
Reacts with
Rabbit, Human, Dog
Application
WB
$289.00
  pAb ARP58718_P050 TRPC6 antibody - N-terminal region (ARP58718_P050)
Reacts with
Human, Horse, Mouse, Rat
Application
WB
$289.00
  pAb ARP38384_P050 EED antibody - N-terminal region (ARP38384_P050)
Reacts with
Human, Rat, Dog, Pig, Horse, Rabbit, Guinea pig, Bovine, Mouse, Zebrafish
Application
WB
$289.00
  pAb ARP35315_P050 KCNJ12 antibody - middle region (ARP35315_P050)
Reacts with
Mouse, Human, Dog, Horse, Rat, Guinea pig, Bovine
Application
WB
$289.00
  pAb ARP34982_P050 GABRA4 antibody - N-terminal region (ARP34982_P050)
Reacts with
Human, Rat, Rabbit, Bovine, Horse
Application
WB
$289.00
  pAb ARP49461_P050 SLC10A3 antibody - middle region (ARP49461_P050)
Reacts with
Horse, Pig, Mouse, Human, Rat, Guinea pig, Dog, Bovine
Application
WB
$289.00
  pAb ARP35542_P050 SCN5A antibody - C-terminal region (ARP35542_P050)
Reacts with
Rat, Zebrafish, Human, Bovine, Dog, Pig, Horse, Rabbit, Guinea pig, Mouse
Application
WB
$289.00
  pAb ARP35179_P050 VDAC3 antibody - N-terminal region (ARP35179_P050)
Reacts with
Bovine, Dog, Human, Pig, Horse, Goat, Rat, Mouse, Rabbit, Guinea pig, Zebrafish
Application
WB
$289.00
  pAb ARP35488_P050 KCNIP2 antibody - N-terminal region (ARP35488_P050)
Reacts with
Pig, Human, Bovine, Dog, Horse, Rat, Guinea pig, Mouse, Rabbit, Zebrafish
Application
WB
$289.00
  pAb ARP37679_P050 KCNK5 antibody - C-terminal region (ARP37679_P050)
Reacts with
Human, Bovine, Horse, Guinea pig, Rat, Dog, Rabbit
Application
WB
$289.00

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Showing 211 - 240 of 306