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Ion Channel Antibodies

Ion channels are a class of membrane-bound proteins that are present on the surface of all cells as well as on intracellular organelles. Ion channels typically function by creating and maintaining an ion gradient across either cellular or organelle membranes. These channels, comprised of a variety of different protein subunits, contain a pore that can be as narrow as a single atom, allowing for precise control of ion passage.

Ion channels play a critical role in the proper functioning of the human nervous system. Voltage-gated ion channels are present on all neurons and it is the voltage gradient created and maintained by these channels that permits signal propagation; a change in the voltage across the membrane can cause the channel to open or close.

Ion channels, such as those that are present at neuronal synapses, can also be ligand-gated in which the binding of a specific ligand will result in a conformational change in the ion channel resulting in pore opening. In addition to voltage- and ligand-activated ion channels, ion channels can also be activated by heat, temperature, or mechanical stress.

Ion channels have a variety of biological functions, including roles in neuronal signal transmission, muscle contraction, T-cell activation, and insulin release from beta cells. Dysfunctional ion channel activity is the basis of many human diseases. For instance, cystic fibrosis is a result of a genetic mutation in the CFTR gene, which encodes a protein component of a chloride ion channel[1]. Specific natural or synthetic toxins can also affect the functional ability of ion channels; the puffer fish produces tetrodotoxin (TTX), which inhibits the function of sodium channels and can cause respiratory paralysis and death.

1. Rogan, et al. 2011. Cystic fibrosis transmembrane conductance regulator intracellular processing, trafficking, and opportunities for mutation-specific treatment. Chest. 139(6):1480-90.

Ion channels are gated, ion-selective glycoproteins that traverse membranes. The stimulus for channel gating can be a membrane potential, drug, transmitter, cytoplasmic messenger, or a mechanical deformation. We have manufactured products for ~200 human ion channel proteins.

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Showing 211 - 240 of 352
  • TRIAL 
    KCNIP2 antibody - N-terminal region (ARP35488_P050) in Human Jurkat using Western Blot

    KCNIP2 antibody - N-terminal region (ARP35488_P050)

    Protein Name:Kv channel-interacting protein 2
    Catalog #:ARP35488_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  •  
    KCNK5 antibody - C-terminal region (ARP37679_P050) in Human HepG2 using Western Blot

    KCNK5 antibody - C-terminal region (ARP37679_P050)

    Protein Name:Potassium channel subfamily K member 5
    Catalog #:ARP37679_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Rabbit, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    KCNJ16 antibody - middle region (ARP35285_P050) in Human 721_B using Western Blot

    KCNJ16 antibody - middle region (ARP35285_P050)

    Protein Name:Inward rectifier potassium channel 16
    Catalog #:ARP35285_P050
    Type: pAb
    Reacts with: Dog, Horse, Human, Pig, Rabbit
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    CACNB4 antibody - C-terminal region (ARP34959_P050) in Human Jurkat using Western Blot

    CACNB4 antibody - C-terminal region (ARP34959_P050)

    Protein Name:Voltage-dependent L-type calcium channel subunit beta-4
    Catalog #:ARP34959_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    SLCO5A1 antibody - middle region (ARP44052_P050) in Human HepG2 using Western Blot

    SLCO5A1 antibody - middle region (ARP44052_P050)

    Protein Name:Solute carrier organic anion transporter family member 5A1
    Catalog #:ARP44052_P050
    Type: pAb
    Reacts with: Cow, Dog, Horse, Human, Mouse, Pig, Rabbit, Rat, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    ACCN4 antibody - N-terminal region (ARP35536_P050) in Human Jurkat using Western Blot

    ACCN4 antibody - N-terminal region (ARP35536_P050)

    Protein Name:Acid-sensing ion channel 4
    Catalog #:ARP35536_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    KCNC3 antibody - middle region (ARP35158_P050) in Human 293T using Western Blot
    KCNC3 antibody - middle region (ARP35158_P050) in Hum. Fetal Lung using Western Blot
    KCNC3 antibody - middle region (ARP35158_P050) in Human 293T using Western Blot
    KCNC3 antibody - middle region (ARP35158_P050) in Human liver using Western Blot

    KCNC3 antibody - middle region (ARP35158_P050)

    Protein Name:Potassium voltage-gated channel subfamily C member 3
    Catalog #:ARP35158_P050
    Type: pAb
    Reacts with: Cow, Guinea Pig, Human, Mouse, Rabbit, Rat
    Application: WB, IHC
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    CACNB2 antibody - N-terminal region (ARP36765_P050) in Human HepG2 using Western Blot

    CACNB2 antibody - N-terminal region (ARP36765_P050)

    Protein Name:Voltage-dependent L-type calcium channel subunit beta-2
    Catalog #:ARP36765_P050
    Type: pAb
    Reacts with: Human
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  •  
    CLCA2 antibody - C-terminal region (ARP35195_P050) in Human THP-1 using Western Blot

    CLCA2 antibody - C-terminal region (ARP35195_P050)

    Protein Name:Calcium-activated chloride channel regulator 2
    Catalog #:ARP35195_P050
    Type: pAb
    Reacts with: Cow, Dog, Horse, Human, Mouse, Pig, Rabbit, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  •  
    CHRFAM7A antibody - N-terminal region (ARP35409_P050) in Human MCF7 using Western Blot

    CHRFAM7A antibody - N-terminal region (ARP35409_P050)

    Protein Name:CHRNA7-FAM7A fusion protein
    Catalog #:ARP35409_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    VDAC2 antibody - N-terminal region (ARP35124_P050) in Human 293T using Western Blot
    VDAC2 antibody - N-terminal region (ARP35124_P050) in Hum. Fetal Brain using Western Blot
    VDAC2 antibody - N-terminal region (ARP35124_P050) in human heart using Immunohistochemistry

    VDAC2 antibody - N-terminal region (ARP35124_P050)

    Protein Name:Voltage-dependent anion-selective channel protein 2
    Catalog #:ARP35124_P050
    Type: pAb
    Reacts with: Cow, Dog, Goat, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
    Application: WB, IHC
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    KCNAB2 antibody - middle region (ARP35460_P050) in Human Jurkat using Western Blot
    KCNAB2 antibody - middle region (ARP35460_P050) in Human HepG2 using Western Blot
    KCNAB2 antibody - middle region (ARP35460_P050) in heart using Immunohistochemistry.

    KCNAB2 antibody - middle region (ARP35460_P050)

    Protein Name:KCNAB2 protein EMBL CAG47060.1
    Catalog #:ARP35460_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
    Application: WB, IHC
    Product Size: 100 ul
    Price (USD): $289.00
  •  
    CHRNA1 antibody - N-terminal region (ARP34909_P050) in Human Jurkat using Western Blot

    CHRNA1 antibody - N-terminal region (ARP34909_P050)

    Protein Name:Acetylcholine receptor subunit alpha
    Catalog #:ARP34909_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  •  
    SCN3B antibody - N-terminal region (ARP37699_P050) in Human DLD1 using Western Blot

    SCN3B antibody - N-terminal region (ARP37699_P050)

    Protein Name:Sodium channel subunit beta-3
    Catalog #:ARP37699_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  •  
    GABRR1 antibody - N-terminal region (ARP35058_P050) in Human HeLa using Western Blot

    GABRR1 antibody - N-terminal region (ARP35058_P050)

    Protein Name:Gamma-aminobutyric acid receptor subunit rho-1
    Catalog #:ARP35058_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    KCNH7 antibody - middle region (ARP35379_P050) in Human Small Intestine using Western Blot

    KCNH7 antibody - middle region (ARP35379_P050)

    Protein Name:Potassium voltage-gated channel subfamily H member 7
    Catalog #:ARP35379_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Rabbit, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  •  
    KCNN4 antibody - C-terminal region (ARP35098_P050) in Human Ovary Tumor using Western Blot

    KCNN4 antibody - C-terminal region (ARP35098_P050)

    Protein Name:Intermediate conductance calcium-activated potassium channel protein 4
    Catalog #:ARP35098_P050
    Type: pAb
    Reacts with: Cow, Horse, Human, Pig, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    SHROOM2 antibody - middle region (ARP35054_P050) in Human Lung using Western Blot

    SHROOM2 antibody - middle region (ARP35054_P050)

    Protein Name:Protein Shroom2
    Catalog #:ARP35054_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rat, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    CACNB2 antibody - middle region (ARP35597_P050) in Human Heart using Western Blot

    CACNB2 antibody - middle region (ARP35597_P050)

    Protein Name:Voltage-dependent L-type calcium channel subunit beta-2
    Catalog #:ARP35597_P050
    Type: pAb
    Reacts with: Cow, Guinea Pig, Human, Mouse, Rabbit, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  •  
    CACNG4 antibody - N-terminal region (ARP35236_P050) in Human 721_B using Western Blot

    CACNG4 antibody - N-terminal region (ARP35236_P050)

    Protein Name:Voltage-dependent calcium channel gamma-4 subunit
    Catalog #:ARP35236_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Yeast, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    KCTD17 antibody - middle region (ARP35359_P050) in Human HepG2 using Western Blot

    KCTD17 antibody - middle region (ARP35359_P050)

    Protein Name:BTB/POZ domain-containing protein KCTD17
    Catalog #:ARP35359_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Human, Mouse, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    GABRG2 antibody - N-terminal region (AVARP13033_P050) in Human Brain using Western Blot

    GABRG2 antibody - N-terminal region (AVARP13033_P050)

    Protein Name:Gamma-aminobutyric acid receptor subunit gamma-2
    Catalog #:AVARP13033_P050
    Type: pAb
    Reacts with: Cow, Dog, Horse, Human, Mouse, Pig, Rabbit, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    CACNG6 antibody - N-terminal region (ARP35369_P050) in Human Spleen using Western Blot

    CACNG6 antibody - N-terminal region (ARP35369_P050)

    Protein Name:Voltage-dependent calcium channel gamma-6 subunit
    Catalog #:ARP35369_P050
    Type: pAb
    Reacts with: Dog, Human, Mouse, Rabbit, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    KCNK12 antibody - middle region (ARP35349_P050) in Human OVCAR-3 using Western Blot

    KCNK12 antibody - middle region (ARP35349_P050)

    Protein Name:Potassium channel subfamily K member 12
    Catalog #:ARP35349_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00

Page of 12

Showing 211 - 240 of 352