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Now Offering Over 85,203 Antibodies & 34,301 Antigens!

Ion Channel Antibodies

Ion channels are a class of membrane-bound proteins that are present on the surface of all cells as well as on intracellular organelles. Ion channels typically function by creating and maintaining an ion gradient across either cellular or organelle membranes. These channels, comprised of a variety of different protein subunits, contain a pore that can be as narrow as a single atom, allowing for precise control of ion passage.

Ion channels play a critical role in the proper functioning of the human nervous system. Voltage-gated ion channels are present on all neurons and it is the voltage gradient created and maintained by these channels that permits signal propagation; a change in the voltage across the membrane can cause the channel to open or close.

Ion channels, such as those that are present at neuronal synapses, can also be ligand-gated in which the binding of a specific ligand will result in a conformational change in the ion channel resulting in pore opening. In addition to voltage- and ligand-activated ion channels, ion channels can also be activated by heat, temperature, or mechanical stress.

Ion channels have a variety of biological functions, including roles in neuronal signal transmission, muscle contraction, T-cell activation, and insulin release from beta cells. Dysfunctional ion channel activity is the basis of many human diseases. For instance, cystic fibrosis is a result of a genetic mutation in the CFTR gene, which encodes a protein component of a chloride ion channel[1]. Specific natural or synthetic toxins can also affect the functional ability of ion channels; the puffer fish produces tetrodotoxin (TTX), which inhibits the function of sodium channels and can cause respiratory paralysis and death.

1. Rogan, et al. 2011. Cystic fibrosis transmembrane conductance regulator intracellular processing, trafficking, and opportunities for mutation-specific treatment. Chest. 139(6):1480-90.

Ion channels are gated, ion-selective glycoproteins that traverse membranes. The stimulus for channel gating can be a membrane potential, drug, transmitter, cytoplasmic messenger, or a mechanical deformation. We have manufactured products for ~200 human ion channel proteins.

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Showing 211 - 240 of 303
  Type Catalog # Product Product Images Price (USD)
  pAb ARP38384_P050 EED antibody - N-terminal region (ARP38384_P050)
Reacts with
Human, Rat, Dog, Pig, Horse, Rabbit, Guinea pig, Bovine, Mouse, Zebrafish
Application
WB
$289.00
  pAb ARP35315_P050 KCNJ12 antibody - middle region (ARP35315_P050)
Reacts with
Mouse, Human, Dog, Horse, Rat, Guinea pig, Bovine
Application
WB
$289.00
  pAb ARP34982_P050 GABRA4 antibody - N-terminal region (ARP34982_P050)
Reacts with
Human, Rat, Rabbit, Bovine, Horse
Application
WB
$289.00
  pAb ARP49461_P050 SLC10A3 antibody - middle region (ARP49461_P050)
Reacts with
Horse, Pig, Mouse, Human, Rat, Guinea pig, Dog, Bovine
Application
WB
$289.00
  pAb ARP35536_P050 ACCN4 antibody - N-terminal region (ARP35536_P050)
Reacts with
Horse, Rabbit, Mouse, Bovine, Dog, Rat, Guinea pig, Human
Application
WB
$289.00
  pAb ARP35158_P050 KCNC3 antibody - middle region (ARP35158_P050)
Reacts with
Mouse, Human, Rat, Pig, Guinea pig, Rabbit, Bovine
Application
WB
$289.00
  pAb ARP37679_P050 KCNK5 antibody - C-terminal region (ARP37679_P050)
Reacts with
Human, Bovine, Horse, Guinea pig, Rat, Dog, Rabbit
Application
WB
$289.00
  pAb ARP35285_P050 KCNJ16 antibody - middle region (ARP35285_P050)
Reacts with
Human, Horse, Dog, Rabbit, Pig
Application
WB
$289.00
  pAb ARP34959_P050 CACNB4 antibody - C-terminal region (ARP34959_P050)
Reacts with
Mouse, Zebrafish, Human, Rat, Dog, Bovine, Horse, Rabbit, Guinea pig
Application
WB
$289.00
  pAb ARP44052_P050 SLCO5A1 antibody - middle region (ARP44052_P050)
Reacts with
Rat, Dog, Zebrafish, Mouse, Bovine, Horse, Rabbit, Human, Pig
Application
WB
$289.00
  pAb ARP35195_P050 CLCA2 antibody - C-terminal region (ARP35195_P050)
Reacts with
Bovine, Human, Rat, Rabbit, Dog, Horse, Mouse, Pig
Application
WB
$289.00
  pAb ARP35409_P050 CHRFAM7A antibody - N-terminal region (ARP35409_P050)
Reacts with
Bovine, Human, Zebrafish, Dog, Horse, Rabbit, Rat, Pig, Guinea pig, Mouse
Application
WB
$289.00
  pAb ARP35124_P050 VDAC2 antibody - N-terminal region (ARP35124_P050)
Reacts with
Human, Dog, Pig, Horse, Rabbit, Rat, Guinea pig, Bovine, Mouse, Zebrafish, Goat
Application
WB
$289.00
  pAb ARP35460_P050 KCNAB2 antibody - middle region (ARP35460_P050)
Reacts with
Human, Mouse, Dog, Horse, Rabbit, Rat, Guinea pig, Bovine, Zebrafish
Application
WB
$289.00
  pAb ARP36765_P050 CACNB2 antibody - N-terminal region (ARP36765_P050)
Reacts with
Human
Application
WB
$289.00
  pAb ARP34909_P050 CHRNA1 antibody - N-terminal region (ARP34909_P050)
Reacts with
Human, Dog, Pig, Horse, Rabbit, Rat, Bovine, Guinea pig, Mouse
Application
WB
$289.00
  pAb ARP37699_P050 SCN3B antibody - N-terminal region (ARP37699_P050)
Reacts with
Mouse, Human, Horse, Rabbit, Bovine, Rat, Dog, Guinea pig
Application
WB
$289.00
  pAb ARP35058_P050 GABRR1 antibody - N-terminal region (ARP35058_P050)
Reacts with
Human, Pig, Horse, Rat, Guinea pig, Dog, Rabbit, Mouse, Bovine, Zebrafish
Application
WB
$289.00
  pAb ARP35379_P050 KCNH7 antibody - middle region (ARP35379_P050)
Reacts with
Bovine, Dog, Pig, Horse, Rat, Guinea pig, Human, Rabbit
Application
WB
$289.00
  pAb ARP35098_P050 KCNN4 antibody - C-terminal region (ARP35098_P050)
Reacts with
Human, Bovine, Horse, Rat, Pig
Application
WB
$289.00
  pAb ARP35444_P050 KCNMB3 antibody - middle region (ARP35444_P050)
Reacts with
Human, Rat, Dog
Application
WB
$289.00
  pAb ARP36744_P050 CACNB1 antibody - C-terminal region (ARP36744_P050)
Reacts with
Mouse, Human, Zebrafish, Bovine, Rabbit, Guinea pig
Application
WB
$289.00
  pAb ARP35245_P050 KCNIP2 antibody - N-terminal region (ARP35245_P050)
Reacts with
Human, Dog, Rabbit
Application
WB
$289.00
  pAb ARP35236_P050 CACNG4 antibody - N-terminal region (ARP35236_P050)
Reacts with
Mouse, Bovine, Pig, Horse, Rabbit, Rat, Guinea pig, Human, Dog, Yeast, Zebrafish
Application
WB
$289.00
  pAb ARP35359_P050 KCTD17 antibody - middle region (ARP35359_P050)
Reacts with
Human, Guinea pig, Mouse, Rat, Bovine, Dog
Application
WB
$289.00
  pAb AVARP13033_P050 GABRG2 antibody - N-terminal region (AVARP13033_P050)
Reacts with
Bovine, Dog, Horse, Human, Mouse, Pig, Rabbit, Rat
Application
WB
$289.00
  pAb ARP35369_P050 CACNG6 antibody - N-terminal region (ARP35369_P050)
Reacts with
Human, Rabbit, Mouse, Rat, Dog
Application
WB
$289.00
  pAb ARP35054_P050 SHROOM2 antibody - middle region (ARP35054_P050)
Reacts with
Mouse, Human, Rat, Bovine, Dog, Pig, Guinea pig, Horse, Zebrafish
Application
WB
$289.00
  pAb ARP35597_P050 CACNB2 antibody - middle region (ARP35597_P050)
Reacts with
Human, Rat, Rabbit, Mouse, Guinea pig, Bovine
Application
WB
$289.00
  pAb ARP35585_P050 TPTE antibody - middle region (ARP35585_P050)
Reacts with
Human
Application
WB
$289.00

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Showing 211 - 240 of 303