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Now Offering Over 85,203 Antibodies & 34,301 Antigens!

Ion Channel Antibodies

Ion channels are a class of membrane-bound proteins that are present on the surface of all cells as well as on intracellular organelles. Ion channels typically function by creating and maintaining an ion gradient across either cellular or organelle membranes. These channels, comprised of a variety of different protein subunits, contain a pore that can be as narrow as a single atom, allowing for precise control of ion passage.

Ion channels play a critical role in the proper functioning of the human nervous system. Voltage-gated ion channels are present on all neurons and it is the voltage gradient created and maintained by these channels that permits signal propagation; a change in the voltage across the membrane can cause the channel to open or close.

Ion channels, such as those that are present at neuronal synapses, can also be ligand-gated in which the binding of a specific ligand will result in a conformational change in the ion channel resulting in pore opening. In addition to voltage- and ligand-activated ion channels, ion channels can also be activated by heat, temperature, or mechanical stress.

Ion channels have a variety of biological functions, including roles in neuronal signal transmission, muscle contraction, T-cell activation, and insulin release from beta cells. Dysfunctional ion channel activity is the basis of many human diseases. For instance, cystic fibrosis is a result of a genetic mutation in the CFTR gene, which encodes a protein component of a chloride ion channel[1]. Specific natural or synthetic toxins can also affect the functional ability of ion channels; the puffer fish produces tetrodotoxin (TTX), which inhibits the function of sodium channels and can cause respiratory paralysis and death.

1. Rogan, et al. 2011. Cystic fibrosis transmembrane conductance regulator intracellular processing, trafficking, and opportunities for mutation-specific treatment. Chest. 139(6):1480-90.

Ion channels are gated, ion-selective glycoproteins that traverse membranes. The stimulus for channel gating can be a membrane potential, drug, transmitter, cytoplasmic messenger, or a mechanical deformation. We have manufactured products for ~200 human ion channel proteins.

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Showing 211 - 240 of 306
  Type Catalog # Product Product Images Price (USD)
  pAb AVARP13014_P050 CHRNA3 antibody - N-terminal region (AVARP13014_P050)
Reacts with
Bovine, Dog, Guinea pig, Human, Mouse, Rabbit, Rat
Application
WB
$289.00
  pAb ARP35349_P050 KCNK12 antibody - middle region (ARP35349_P050)
Reacts with
Bovine, Pig, Rabbit, Guinea pig, Dog, Mouse, Rat, Human, Zebrafish, Horse
Application
WB
$289.00
  pAb ARP35016_P050 GRIN2C antibody - N-terminal region (ARP35016_P050)
Reacts with
Mouse, Human, Rat, Dog, Bovine, Pig, Guinea pig, Rabbit, Zebrafish
Application
WB
$289.00
  pAb ARP50110_P050 FCRLA antibody - middle region (ARP50110_P050)
Reacts with
Human
Application
WB
$289.00
  pAb ARP35585_P050 TPTE antibody - middle region (ARP35585_P050)
Reacts with
Human
Application
WB
$289.00
  pAb ARP35211_P050 KCND2 antibody - middle region (ARP35211_P050)
Reacts with
Human, Bovine, Horse, Rat, Pig, Rabbit, Mouse, Dog
Application
WB
$289.00
  pAb ARP35503_P050 KCNRG antibody - N-terminal region (ARP35503_P050)
Reacts with
Human, Dog, Horse, Rabbit, Rat, Pig, Bovine
Application
WB
$289.00
  pAb ARP44475_P050 UMODL1 antibody - middle region (ARP44475_P050)
Reacts with
Human, Rat, Bovine, Dog, Pig, Mouse, Horse, Guinea pig
Application
WB
$289.00
  pAb ARP35572_P050 KCTD4 antibody - middle region (ARP35572_P050)
Reacts with
Bovine, Dog, Horse, Guinea pig, Zebrafish, Human, Rat, Rabbit, Mouse
Application
WB
$289.00
  pAb ARP35171_P050 KCNJ9 antibody - middle region (ARP35171_P050)
Reacts with
Bovine, Pig, Rat, Guinea pig, Mouse, Human, Goat, Dog, Rabbit, Zebrafish, Horse
Application
WB
$289.00
  pAb ARP35481_P050 KCNH6 antibody - middle region (ARP35481_P050)
Reacts with
Human, Mouse, Bovine, Horse, Rabbit, Rat, Pig, Dog
Application
WB
$289.00
  pAb ARP37689_P050 TPTE antibody - middle region (ARP37689_P050)
Reacts with
Human
Application
WB
$289.00
  pAb ARP35300_P050 NMUR2 antibody - N-terminal region (ARP35300_P050)
Reacts with
Human
Application
WB
$289.00
  pAb ARP57724_P050 IL17D antibody - N-terminal region (ARP57724_P050)
Reacts with
Bovine, Guinea pig, Mouse, Human
Application
WB
$289.00
  pAb ARP35132_P050 CLCNKA antibody - N-terminal region (ARP35132_P050)
Reacts with
Human, Bovine, Mouse, Rat, Pig
Application
WB
$289.00
  pAb ARP35469_P050 KCNG1 antibody - N-terminal region (ARP35469_P050)
Reacts with
Human, Mouse, Pig, Rat, Bovine, Rabbit, Guinea pig, Dog, Horse
Application
WB
$289.00
  pAb ARP37668_P050 CACNG1 antibody - N-terminal region (ARP37668_P050)
Reacts with
Rat, Guinea pig, Mouse, Rabbit, Human, Horse, Bovine, Dog
Application
WB
$289.00
  pAb ARP35276_P050 TPCN1 antibody - N-terminal region (ARP35276_P050)
Reacts with
Zebrafish, Human, Dog, Bovine, Horse, Rabbit, Rat, Guinea pig, Mouse
Application
WB
$289.00
  pAb ARP34952_P050 CACNA2D1 antibody - middle region (ARP34952_P050)
Reacts with
Rat, Mouse, Bovine, Dog, Horse, Rabbit, Guinea pig, Human
Application
WB
$289.00
  pAb ARP35396_P050 KCNV2 antibody - N-terminal region (ARP35396_P050)
Reacts with
Human, Pig
Application
WB
$289.00
  pAb ARP35456_P050 KCNQ2 antibody - N-terminal region (ARP35456_P050)
Reacts with
Human, Mouse, Rat, Bovine, Dog, Horse, Guinea pig, Zebrafish, Rabbit
Application
WB
$289.00
  pAb ARP36752_P050 KCNRG antibody - N-terminal region (ARP36752_P050)
Reacts with
Horse, Human
Application
WB
$289.00
  pAb ARP35253_P050 KCTD3 antibody - middle region (ARP35253_P050)
Reacts with
Human, Bovine, Dog, Horse, Rabbit, Guinea pig, Rat, Mouse, Zebrafish
Application
IHC, WB
$289.00
  pAb ARP34916_P050 CLCNKB antibody - N-terminal region (ARP34916_P050)
Reacts with
Human, Horse, Mouse, Bovine, Rat, Guinea pig, Rabbit, Dog
Application
WB
$289.00
  pAb ARP37698_P050 MCOLN3 antibody - middle region (ARP37698_P050)
Reacts with
Pig, Human, Dog, Rat, Rabbit, Guinea pig, Bovine, Mouse, Horse, Zebrafish
Application
WB
$289.00
  pAb ARP35373_P050 TOMM40L antibody - middle region (ARP35373_P050)
Reacts with
Rat, Bovine, Human, Mouse, Dog, Pig, Horse, Rabbit, Guinea pig, Zebrafish
Application
WB
$289.00
  pAb ARP35076_P050 KCNG1 antibody - N-terminal region (ARP35076_P050)
Reacts with
Human, Dog, Mouse, Pig, Rat, Bovine, Guinea pig, Rabbit, Horse
Application
WB
$289.00
  pAb ARP35434_P050 P2RX2 antibody - N-terminal region (ARP35434_P050)
Reacts with
Human, Guinea pig, Rabbit, Rat, Mouse, Bovine, Dog, Horse
Application
WB
$289.00
  pAb ARP36596_P050 CHRFAM7A antibody - middle region (ARP36596_P050)
Reacts with
Bovine, Human, Pig, Dog, Horse, Rabbit, Rat, Guinea pig, Mouse, Zebrafish
Application
WB
$289.00
  pAb ARP35241_P050 KCNMB4 antibody - middle region (ARP35241_P050)
Reacts with
Pig, Bovine, Sheep, Rabbit, Rat, Guinea pig, Human, Mouse
Application
WB
$289.00

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Showing 211 - 240 of 306