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Now Offering Over 85,203 Antibodies & 34,301 Antigens!

Ion Channel Antibodies

Ion channels are a class of membrane-bound proteins that are present on the surface of all cells as well as on intracellular organelles. Ion channels typically function by creating and maintaining an ion gradient across either cellular or organelle membranes. These channels, comprised of a variety of different protein subunits, contain a pore that can be as narrow as a single atom, allowing for precise control of ion passage.

Ion channels play a critical role in the proper functioning of the human nervous system. Voltage-gated ion channels are present on all neurons and it is the voltage gradient created and maintained by these channels that permits signal propagation; a change in the voltage across the membrane can cause the channel to open or close.

Ion channels, such as those that are present at neuronal synapses, can also be ligand-gated in which the binding of a specific ligand will result in a conformational change in the ion channel resulting in pore opening. In addition to voltage- and ligand-activated ion channels, ion channels can also be activated by heat, temperature, or mechanical stress.

Ion channels have a variety of biological functions, including roles in neuronal signal transmission, muscle contraction, T-cell activation, and insulin release from beta cells. Dysfunctional ion channel activity is the basis of many human diseases. For instance, cystic fibrosis is a result of a genetic mutation in the CFTR gene, which encodes a protein component of a chloride ion channel[1]. Specific natural or synthetic toxins can also affect the functional ability of ion channels; the puffer fish produces tetrodotoxin (TTX), which inhibits the function of sodium channels and can cause respiratory paralysis and death.

1. Rogan, et al. 2011. Cystic fibrosis transmembrane conductance regulator intracellular processing, trafficking, and opportunities for mutation-specific treatment. Chest. 139(6):1480-90.

Ion channels are gated, ion-selective glycoproteins that traverse membranes. The stimulus for channel gating can be a membrane potential, drug, transmitter, cytoplasmic messenger, or a mechanical deformation. We have manufactured products for ~200 human ion channel proteins.

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Showing 211 - 240 of 306
  Type Catalog # Product Product Images Price (USD)
  pAb ARP35298_P050 ACCN2 antibody - N-terminal region (ARP35298_P050)
Reacts with
Human, Horse, Rabbit, Guinea pig, Dog, Rat, Mouse, Bovine
Application
WB
$289.00
  pAb ARP34965_P050 CHRNA4 antibody - N-terminal region (ARP34965_P050)
Reacts with
Mouse, Guinea pig, Human, Rat, Dog, Zebrafish, Bovine, Horse, Rabbit
Application
WB
$289.00
  pAb ARP57727_P050 NDNL2 antibody - middle region (ARP57727_P050)
Reacts with
Pig, Horse, Rabbit, Guinea pig, Rat, Mouse, Human, Bovine
Application
WB
$289.00
  pAb ARP35537_P050 ACCN1 antibody - middle region (ARP35537_P050)
Reacts with
Human, Mouse, Horse, Bovine, Dog, Rabbit, Rat, Zebrafish
Application
WB
$289.00
  pAb ARP35126_P050 KCNAB1 antibody - C-terminal region (ARP35126_P050)
Reacts with
Bovine, Human, Dog, Horse, Rabbit, Guinea pig, Mouse, Rat, Zebrafish
Application
IHC, WB
$289.00
  pAb ARP35467_P050 KCND3 antibody - middle region (ARP35467_P050)
Reacts with
Pig, Mouse, Human, Rat, Bovine, Horse, Rabbit, Guinea pig, Dog
Application
WB
$289.00
  pAb ARP36776_P050 TRPM3 antibody - N-terminal region (ARP36776_P050)
Reacts with
Human, Zebrafish, Mouse, Rat, Bovine, Dog, Horse, Rabbit, Guinea pig
Application
WB
$289.00
  pAb ARP35268_P050 TRPM4 antibody - N-terminal region (ARP35268_P050)
Reacts with
Rat, Mouse, Human, Guinea pig, Dog, Horse, Bovine
Application
WB
$289.00
  pAb ARP43955_P050 SLC25A44 antibody - middle region (ARP43955_P050)
Reacts with
Bovine, Human, Rat, Dog, Zebrafish, Pig, Horse, Rabbit, Guinea pig, Mouse
Application
WB
$289.00
  pAb ARP35388_P050 CLIC6 antibody - middle region (ARP35388_P050)
Reacts with
Rat, Rabbit, Pig, Mouse, Human
Application
WB
$289.00
  pAb ARP35100_P050 KCNS1 antibody - N-terminal region (ARP35100_P050)
Reacts with
Human
Application
WB
$289.00
  pAb ARP35450_P050 KCNH2 antibody - middle region (ARP35450_P050)
Reacts with
Guinea pig, Horse, Rat, Bovine, Dog, Rabbit, Mouse, Human
Application
WB
$289.00
  pAb ARP36747_T100 TPTE antibody - C-terminal region (ARP36747_T100)
Reacts with
Human
Application
WB
$229.00
  pAb ARP34910_P050 CHRNA1 antibody - N-terminal region (ARP34910_P050)
Reacts with
Human, Dog, Pig, Horse, Rabbit, Guinea pig, Bovine, Mouse, Rat
Application
WB
$289.00
  pAb ARP30697_P050 GABRR1 antibody - N-terminal region (ARP30697_P050)
Reacts with
Human, Rat, Guinea pig, Rabbit
Application
WB
$289.00
  pAb ARP35371_P050 KCTD10 antibody - middle region (ARP35371_P050)
Reacts with
Bovine, Human, Dog, Pig, Horse, Mouse, Rabbit, Rat, Guinea pig, Zebrafish
Application
WB
$289.00
  pAb ARP35060_P050 GABRR2 antibody - middle region (ARP35060_P050)
Reacts with
Human, Dog, Rat, Mouse, Bovine, Zebrafish, Pig, Horse, Rabbit, Guinea pig
Application
WB
$289.00
  pAb ARP35600_P050 CACNB2 antibody - middle region (ARP35600_P050)
Reacts with
Mouse, Zebrafish, Human, Rat, Dog, Bovine, Pig, Horse, Rabbit, Guinea pig
Application
WB
$289.00
  pAb ARP35237_P050 CCT8L2 antibody - middle region (ARP35237_P050)
Reacts with
Human, Rabbit, Guinea pig
Application
WB
$289.00
  pAb ARP34966_P050 CHRNA5 antibody - middle region (ARP34966_P050)
Reacts with
Human, Rabbit, Rat, Mouse, Pig, Horse, Bovine, Dog
Application
WB
$289.00
  pAb AVARP13015_P050 CHRNA4 antibody - N-terminal region (AVARP13015_P050)
Reacts with
Bovine, Guinea pig, Human, Mouse, Rabbit, Rat
Application
WB
$289.00
  pAb ARP35350_P050 KCNK15 antibody - middle region (ARP35350_P050)
Reacts with
Human, Dog, Pig, Bovine
Application
WB
$289.00
  pAb ARP35020_P050 KCNJ5 antibody - N-terminal region (ARP35020_P050)
Reacts with
Human, Dog, Rat, Bovine, Horse, Pig, Mouse, Rabbit
Application
WB
$289.00
  pAb ARP35602_P050 CACNB2 antibody - middle region (ARP35602_P050)
Reacts with
Human
Application
WB
$289.00
  pAb ARP34935_P050 SCN5A Antibody - C-terminal region (ARP34935_P050)
Reacts with
Human, Rat, Guinea pig, Bovine, Dog, Horse, Mouse
Application
WB
$289.00
  pAb ARP35588_T100 KCNRG antibody - N-terminal region (ARP35588_T100)
Reacts with
Human, Horse, Rabbit, Dog, Pig, Bovine, Rat
Application
WB
$229.00
  pAb ARP35214_P050 KCNH3 antibody - middle region (ARP35214_P050)
Reacts with
Human, Horse, Rabbit, Mouse, Dog, Guinea pig, Bovine, Rat
Application
WB
$289.00
  pAb ARP35505_P050 P2RX2 antibody - middle region (ARP35505_P050)
Reacts with
Human, Guinea pig, Bovine, Dog, Horse, Rat, Mouse, Rabbit, Zebrafish
Application
WB
$289.00
  pAb ARP35284_P050 Trpv6 antibody - middle region (ARP35284_P050)
Reacts with
Human, Horse, Dog, Rabbit, Rat, Guinea pig, Mouse
Application
IHC, WB
$289.00
  pAb ARP50109_P050 BEST3 antibody - N-terminal region (ARP50109_P050)
Reacts with
Bovine, Dog, Zebrafish, Rat, Human, Pig, Horse, Rabbit, Guinea pig, Mouse
Application
WB
$289.00

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Showing 211 - 240 of 306