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Now Offering Over 85,203 Antibodies & 34,301 Antigens!

Ion Channel Antibodies

Ion channels are a class of membrane-bound proteins that are present on the surface of all cells as well as on intracellular organelles. Ion channels typically function by creating and maintaining an ion gradient across either cellular or organelle membranes. These channels, comprised of a variety of different protein subunits, contain a pore that can be as narrow as a single atom, allowing for precise control of ion passage.

Ion channels play a critical role in the proper functioning of the human nervous system. Voltage-gated ion channels are present on all neurons and it is the voltage gradient created and maintained by these channels that permits signal propagation; a change in the voltage across the membrane can cause the channel to open or close.

Ion channels, such as those that are present at neuronal synapses, can also be ligand-gated in which the binding of a specific ligand will result in a conformational change in the ion channel resulting in pore opening. In addition to voltage- and ligand-activated ion channels, ion channels can also be activated by heat, temperature, or mechanical stress.

Ion channels have a variety of biological functions, including roles in neuronal signal transmission, muscle contraction, T-cell activation, and insulin release from beta cells. Dysfunctional ion channel activity is the basis of many human diseases. For instance, cystic fibrosis is a result of a genetic mutation in the CFTR gene, which encodes a protein component of a chloride ion channel[1]. Specific natural or synthetic toxins can also affect the functional ability of ion channels; the puffer fish produces tetrodotoxin (TTX), which inhibits the function of sodium channels and can cause respiratory paralysis and death.

1. Rogan, et al. 2011. Cystic fibrosis transmembrane conductance regulator intracellular processing, trafficking, and opportunities for mutation-specific treatment. Chest. 139(6):1480-90.

Ion channels are gated, ion-selective glycoproteins that traverse membranes. The stimulus for channel gating can be a membrane potential, drug, transmitter, cytoplasmic messenger, or a mechanical deformation. We have manufactured products for ~200 human ion channel proteins.

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Showing 211 - 240 of 306
  Type Catalog # Product Product Images Price (USD)
  pAb ARP35173_P050 P2RXL1 antibody - N-terminal region (ARP35173_P050)
Reacts with
Bovine, Human, Pig, Horse, Rabbit, Rat, Guinea pig, Dog, Mouse
Application
WB
$289.00
  pAb ARP35484_P050 KCNH7 antibody - N-terminal region (ARP35484_P050)
Reacts with
Dog, Pig, Horse, Rabbit, Guinea pig, Rat, Mouse, Human, Bovine
Application
WB
$289.00
  pAb ARP37693_P050 KCNV1 antibody - N-terminal region (ARP37693_P050)
Reacts with
Human, Pig, Rabbit, Guinea pig, Rat, Mouse, Dog, Bovine, Horse
Application
WB
$289.00
  pAb ARP35307_P050 MCOLN1 antibody - N-terminal region (ARP35307_P050)
Reacts with
Human, Dog, Pig, Rabbit, Rat, Bovine, Horse, Guinea pig, Mouse
Application
WB
$289.00
  pAb ARP34976_P050 GABRA1 antibody - N-terminal region (ARP34976_P050)
Reacts with
Human, Rabbit, Bovine, Dog, Mouse, Rat, Pig
Application
WB
$289.00
  pAb ARP57720_P050 RAD51L1 antibody - middle region (ARP57720_P050)
Reacts with
Human, Dog, Rabbit, Guinea pig, Rat, Bovine, Mouse, Horse
Application
WB
$289.00
  pAb ARP43870_P050 SLC9A3 antibody - middle region (ARP43870_P050)
Reacts with
Human, Dog, Rat, Mouse, Pig, Bovine, Rabbit, Sheep
Application
WB
$289.00
  pAb ARP35525_P050 LGICZ1 antibody - N-terminal region (ARP35525_P050)
Reacts with
Pig, Human, Dog, Horse, Rabbit, Bovine
Application
WB
$289.00
  pAb ARP35470_P050 KCNG1 antibody - N-terminal region (ARP35470_P050)
Reacts with
Human, Mouse, Rat, Guinea pig
Application
WB
$289.00
  pAb ARP35278_P050 MCOLN3 antibody - middle region (ARP35278_P050)
Reacts with
Pig, Human, Bovine, Rat, Rabbit, Guinea pig, Mouse, Dog, Horse, Zebrafish
Application
WB
$289.00
  pAb ARP34953_P050 CACNB1 antibody - N-terminal region (ARP34953_P050)
Reacts with
Mouse, Zebrafish, Human, Dog, Pig, Bovine, Horse, Rabbit, Rat, Guinea pig
Application
WB
$289.00
  pAb ARP34917_P050 CLCNKB antibody - C-terminal region (ARP34917_P050)
Reacts with
Human, Bovine, Pig, Horse, Rabbit, Rat, Mouse, Dog, Guinea pig
Application
WB
$289.00
  pAb ARP35101_P050 KCNS1 antibody - N-terminal region (ARP35101_P050)
Reacts with
Human, Bovine, Dog, Rat, Guinea pig, Mouse, Horse, Rabbit, Zebrafish
Application
WB
$289.00
  pAb ARP35398_P050 KCNK10 antibody - N-terminal region (ARP35398_P050)
Reacts with
Human, Dog, Bovine, Pig, Horse, Guinea pig, Mouse, Rabbit, Rat
Application
WB
$289.00
  pAb ARP35457_P050 KCNQ2 antibody - middle region (ARP35457_P050)
Reacts with
Human, Mouse, Rat, Bovine, Dog, Horse, Guinea pig, Zebrafish, Rabbit
Application
IHC, WB
$289.00
  pAb ARP36758_P050 CACNB2 antibody - N-terminal region (ARP36758_P050)
Reacts with
Human, Mouse, Rabbit, Rat, Bovine
Application
WB
$289.00
  pAb ARP35256_P050 TRPC4 antibody - middle region (ARP35256_P050)
Reacts with
Human, Rabbit, Mouse, Dog, Rat, Bovine, Pig, Guinea pig, Horse
Application
IHC, WB
$289.00
  pAb ARP35242_P050 TRPM5 antibody - N-terminal region (ARP35242_P050)
Reacts with
Human, Mouse, Dog, Horse, Bovine, Rat, Guinea pig
Application
IHC, WB
$289.00
  pAb ARP33975_P050 KCNB1 antibody - middle region (ARP33975_P050)
Reacts with
Human, Dog, Pig, Bovine, Horse, Rat, Guinea pig, Mouse
Application
WB
$289.00
  pAb ARP59578_P050 BSND antibody - middle region (ARP59578_P050)
Reacts with
Human
Application
WB
$289.00
  pAb ARP35374_P050 TOMM40L antibody - middle region (ARP35374_P050)
Reacts with
Bovine, Human, Dog, Pig, Horse, Rabbit, Rat, Guinea pig, Mouse, Zebrafish
Application
WB
$289.00
  pAb ARP35089_P050 KCNK1 antibody - middle region (ARP35089_P050)
Reacts with
Human, Pig, Horse, Rabbit, Dog, Rat, Guinea pig, Bovine, Mouse
Application
WB
$289.00
  pAb ARP35436_P050 P2RX2 antibody - N-terminal region (ARP35436_P050)
Reacts with
Human, Rat, Guinea pig, Rabbit, Bovine
Application
IHC, WB
$289.00
  pAb ARP36723_P050 KCNK6 antibody - N-terminal region (ARP36723_P050)
Reacts with
Human, Bovine, Pig
Application
WB
$289.00
  pAb ARP35592_P050 CACNB2 antibody - middle region (ARP35592_P050)
Reacts with
Human, Mouse, Rat, Horse, Rabbit, Bovine, Guinea pig, Dog
Application
WB
$289.00
  pAb ARP35226_T100 FXYD5 antibody - middle region (ARP35226_T100)
Reacts with
Human
Application
WB
$229.00
  pAb ARP35511_P050 P2RX5 antibody - N-terminal region (ARP35511_P050)
Reacts with
Human, Rat, Guinea pig, Mouse, Bovine, Rabbit, Dog
Application
WB
$289.00
  pAb ARP35362_P050 KCNH6 antibody - middle region (ARP35362_P050)
Reacts with
Human, Rat
Application
WB
$289.00
  pAb ARP35033_P050 ACCN1 antibody - C-terminal region (ARP35033_P050)
Reacts with
Human, Horse, Dog, Rabbit, Rat, Mouse, Bovine
Application
WB
$289.00
  pAb ARP35172_P050 P2RXL1 antibody - N-terminal region (ARP35172_P050)
Reacts with
Human, Dog, Mouse, Rabbit, Bovine, Pig, Horse, Rat, Guinea pig
Application
WB
$289.00

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Showing 211 - 240 of 306