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Aviva Systems Biology

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Now Offering Over 85,203 Antibodies & 34,301 Antigens!

Ion Channel Antibodies

Ion channels are a class of membrane-bound proteins that are present on the surface of all cells as well as on intracellular organelles. Ion channels typically function by creating and maintaining an ion gradient across either cellular or organelle membranes. These channels, comprised of a variety of different protein subunits, contain a pore that can be as narrow as a single atom, allowing for precise control of ion passage.

Ion channels play a critical role in the proper functioning of the human nervous system. Voltage-gated ion channels are present on all neurons and it is the voltage gradient created and maintained by these channels that permits signal propagation; a change in the voltage across the membrane can cause the channel to open or close.

Ion channels, such as those that are present at neuronal synapses, can also be ligand-gated in which the binding of a specific ligand will result in a conformational change in the ion channel resulting in pore opening. In addition to voltage- and ligand-activated ion channels, ion channels can also be activated by heat, temperature, or mechanical stress.

Ion channels have a variety of biological functions, including roles in neuronal signal transmission, muscle contraction, T-cell activation, and insulin release from beta cells. Dysfunctional ion channel activity is the basis of many human diseases. For instance, cystic fibrosis is a result of a genetic mutation in the CFTR gene, which encodes a protein component of a chloride ion channel[1]. Specific natural or synthetic toxins can also affect the functional ability of ion channels; the puffer fish produces tetrodotoxin (TTX), which inhibits the function of sodium channels and can cause respiratory paralysis and death.

1. Rogan, et al. 2011. Cystic fibrosis transmembrane conductance regulator intracellular processing, trafficking, and opportunities for mutation-specific treatment. Chest. 139(6):1480-90.

Ion channels are gated, ion-selective glycoproteins that traverse membranes. The stimulus for channel gating can be a membrane potential, drug, transmitter, cytoplasmic messenger, or a mechanical deformation. We have manufactured products for ~200 human ion channel proteins.

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Showing 211 - 240 of 294
  Type Catalog # Product Product Images Price (USD)
  pAb ARP36411_P050 Dhx38 antibody - N-terminal region (ARP36411_P050)
Reacts with
Human, Rat, Dog, Bovine, Horse, Rabbit, Guinea pig, Mouse, Zebrafish
Application
WB
$289.00
  pAb ARP36587_P050 Anxa11 antibody - C-terminal region (ARP36587_P050)
Reacts with
Human, Mouse, Dog, Bovine, Pig, Horse, Rabbit, Rat, Guinea pig, Zebrafish
Application
WB
$289.00
  pAb ARP36596_P050 CHRFAM7A antibody - middle region (ARP36596_P050)
Reacts with
Bovine, Human, Pig, Dog, Horse, Rabbit, Rat, Guinea pig, Mouse, Zebrafish
Application
WB
$289.00
  pAb ARP36606_P050 Tjp1 antibody - N-terminal region (ARP36606_P050)
Reacts with
Human, Mouse, Zebrafish, Rat, Bovine, Dog, Horse, Rabbit, Guinea pig
Application
WB
$289.00
  pAb ARP36648_P050 Mcm4 antibody - N-terminal region (ARP36648_P050)
Reacts with
Human, Bovine, Dog, Pig, Horse, Rabbit, Rat, Mouse, Guinea pig, Zebrafish
Application
WB
$289.00
  pAb ARP36723_P050 KCNK6 antibody - N-terminal region (ARP36723_P050)
Reacts with
Human, Bovine, Pig
Application
WB
$289.00
  pAb ARP36736_P050 KCTD4 antibody - middle region (ARP36736_P050)
Reacts with
Bovine, Rat, Dog, Horse, Rabbit, Guinea pig, Human, Mouse
Application
WB
$289.00
  pAb ARP36738_P050 GABRG2 Antibody - N-terminal region (ARP36738_P050)
Reacts with
Dog, Human, Bovine, Pig, Horse, Rabbit, Rat, Guinea pig, Mouse
Application
WB
$289.00
  pAb ARP36744_P050 CACNB1 antibody - C-terminal region (ARP36744_P050)
Reacts with
Mouse, Human, Zebrafish, Bovine, Rabbit, Guinea pig
Application
WB
$289.00
  pAb ARP36747_T100 TPTE antibody - C-terminal region (ARP36747_T100)
Reacts with
Human
Application
WB
$229.00
  pAb ARP36752_P050 KCNRG antibody - N-terminal region (ARP36752_P050)
Reacts with
Horse, Human
Application
WB
$289.00
  pAb ARP36758_P050 CACNB2 antibody - N-terminal region (ARP36758_P050)
Reacts with
Human, Mouse, Rabbit, Rat, Bovine
Application
WB
$289.00
  pAb ARP36761_P050 CACNB2 antibody - C-terminal region (ARP36761_P050)
Reacts with
Human, Mouse, Rat, Dog, Pig, Horse, Rabbit, Guinea pig, Bovine
Application
WB
$289.00
  pAb ARP36765_P050 CACNB2 antibody - N-terminal region (ARP36765_P050)
Reacts with
Human
Application
WB
$289.00
  pAb ARP36776_P050 TRPM3 antibody - N-terminal region (ARP36776_P050)
Reacts with
Human, Zebrafish, Mouse, Rat, Bovine, Dog, Horse, Rabbit, Guinea pig
Application
WB
$289.00
  pAb ARP37668_P050 CACNG1 antibody - N-terminal region (ARP37668_P050)
Reacts with
Rat, Guinea pig, Mouse, Rabbit, Human, Horse, Bovine, Dog
Application
WB
$289.00
  pAb ARP37674_P050 GRIK5 Antibody (ARP37674_P050)
Reacts with
Bovine, Dog, Pig, Horse, Rabbit, Rat, Guinea pig, Human, Mouse, Zebrafish
Application
WB, IHC
$289.00
  pAb ARP37678_P050 KCNAB2 antibody - middle region (ARP37678_P050)
Reacts with
Human, Zebrafish, Mouse, Dog, Horse, Rabbit, Rat, Guinea pig, Bovine, Yeast
Application
IHC, WB
$289.00
  pAb ARP37679_P050 KCNK5 antibody - C-terminal region (ARP37679_P050)
Reacts with
Human, Bovine, Horse, Guinea pig, Rat, Dog, Rabbit
Application
WB
$289.00
  pAb ARP37688_P050 KCNH3 antibody - middle region (ARP37688_P050)
Reacts with
Human, Mouse, Rabbit, Rat, Bovine, Dog, Horse, Guinea pig
Application
WB
$289.00
  pAb ARP37689_P050 TPTE antibody - middle region (ARP37689_P050)
Reacts with
Human
Application
WB
$289.00
  pAb ARP37693_P050 KCNV1 antibody - N-terminal region (ARP37693_P050)
Reacts with
Human, Pig, Rabbit, Guinea pig, Rat, Mouse, Dog, Bovine, Horse
Application
WB
$289.00
  pAb ARP37698_P050 MCOLN3 antibody - middle region (ARP37698_P050)
Reacts with
Pig, Human, Dog, Rat, Rabbit, Guinea pig, Bovine, Mouse, Horse, Zebrafish
Application
WB
$289.00
  pAb ARP37699_P050 SCN3B antibody - N-terminal region (ARP37699_P050)
Reacts with
Mouse, Human, Horse, Rabbit, Bovine, Rat, Dog, Guinea pig
Application
WB
$289.00
  pAb ARP37700_P050 KCNQ5 antibody - middle region (ARP37700_P050)
Reacts with
Human, Horse, Rabbit, Mouse, Rat, Dog, Pig, Bovine, Guinea pig
Application
WB
$289.00
  pAb ARP37996_P050 Twist1 antibody - N-terminal region (ARP37996_P050)
Reacts with
Horse, Bovine, Mouse, Human, Rat, Zebrafish
Application
WB
$289.00
  pAb ARP38384_P050 EED antibody - N-terminal region (ARP38384_P050)
Reacts with
Human, Rat, Dog, Pig, Horse, Rabbit, Guinea pig, Bovine, Mouse, Zebrafish
Application
WB
$289.00
  pAb ARP39226_P050 Zfr antibody - N-terminal region (ARP39226_P050)
Reacts with
Zebrafish, Human, Mouse, Dog, Rabbit, Rat
Application
WB
$289.00
  pAb ARP41184_P050 Mrpl21 antibody - middle region (ARP41184_P050)
Reacts with
Human, Rat, Horse, Guinea pig, Dog, Mouse, Bovine
Application
WB
$289.00
  pAb ARP41373_P050 Insr antibody - middle region (ARP41373_P050)
Reacts with
Dog, Rat, Bovine, Pig, Horse, Rabbit, Guinea pig, Mouse, Human, Sheep
Application
WB
$289.00

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Showing 211 - 240 of 294