website statistics
Account Login 

Now Offering Over 102,157 Antibodies & 44,722 Antigens!

US

Ion Channel Antibodies

Ion channels are a class of membrane-bound proteins that are present on the surface of all cells as well as on intracellular organelles. Ion channels typically function by creating and maintaining an ion gradient across either cellular or organelle membranes. These channels, comprised of a variety of different protein subunits, contain a pore that can be as narrow as a single atom, allowing for precise control of ion passage.

Ion channels play a critical role in the proper functioning of the human nervous system. Voltage-gated ion channels are present on all neurons and it is the voltage gradient created and maintained by these channels that permits signal propagation; a change in the voltage across the membrane can cause the channel to open or close.

Ion channels, such as those that are present at neuronal synapses, can also be ligand-gated in which the binding of a specific ligand will result in a conformational change in the ion channel resulting in pore opening. In addition to voltage- and ligand-activated ion channels, ion channels can also be activated by heat, temperature, or mechanical stress.

Ion channels have a variety of biological functions, including roles in neuronal signal transmission, muscle contraction, T-cell activation, and insulin release from beta cells. Dysfunctional ion channel activity is the basis of many human diseases. For instance, cystic fibrosis is a result of a genetic mutation in the CFTR gene, which encodes a protein component of a chloride ion channel[1]. Specific natural or synthetic toxins can also affect the functional ability of ion channels; the puffer fish produces tetrodotoxin (TTX), which inhibits the function of sodium channels and can cause respiratory paralysis and death.

1. Rogan, et al. 2011. Cystic fibrosis transmembrane conductance regulator intracellular processing, trafficking, and opportunities for mutation-specific treatment. Chest. 139(6):1480-90.

Ion channels are gated, ion-selective glycoproteins that traverse membranes. The stimulus for channel gating can be a membrane potential, drug, transmitter, cytoplasmic messenger, or a mechanical deformation. We have manufactured products for ~200 human ion channel proteins.

Page of 12

Showing 211 - 240 of 356
  • TRIAL 
    LGICZ1 antibody - N-terminal region (ARP35525_P050) in Human NCI-H226 using Western Blot

    LGICZ1 antibody - N-terminal region (ARP35525_P050)

    Protein Name:Zinc-activated ligand-gated ion channel
    Catalog #:ARP35525_P050
    Type: pAb
    Reacts with: Cow, Dog, Horse, Human, Pig, Rabbit
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    KCNG1 antibody - N-terminal region (ARP35470_P050) in Human Liver using Western Blot

    KCNG1 antibody - N-terminal region (ARP35470_P050)

    Protein Name:Potassium voltage-gated channel subfamily G member 1
    Catalog #:ARP35470_P050
    Type: pAb
    Reacts with: Guinea Pig, Human, Mouse, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  •  
    MCOLN3 antibody - middle region (ARP35278_P050) in Human PANC1 using Western Blot

    MCOLN3 antibody - middle region (ARP35278_P050)

    Protein Name:Mucolipin-3
    Catalog #:ARP35278_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  •  
    CACNB1 antibody - N-terminal region (ARP34953_P050) in Human HepG2 using Western Blot
    CACNB1 antibody - N-terminal region (ARP34953_P050) in Hum. Fetal Heart using Western Blot
    CACNB1 antibody - N-terminal region (ARP34953_P050) in Hum. Fetal Lung using Western Blot
    CACNB1 antibody - N-terminal region (ARP34953_P050) in Hum. Fetal Liver using Western Blot

    CACNB1 antibody - N-terminal region (ARP34953_P050)

    Protein Name:Voltage-dependent L-type calcium channel subunit beta-1
    Catalog #:ARP34953_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    CLCNKB antibody - C-terminal region (ARP34917_P050) in Human kidney using Western Blot

    CLCNKB antibody - C-terminal region (ARP34917_P050)

    Protein Name:Chloride channel protein ClC-Kb
    Catalog #:ARP34917_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    KCNS1 antibody - N-terminal region (ARP35101_P050) in Human HepG2 using Western Blot

    KCNS1 antibody - N-terminal region (ARP35101_P050)

    Protein Name:Potassium voltage-gated channel subfamily S member 1
    Catalog #:ARP35101_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    KCNK10 antibody - N-terminal region (ARP35398_P050) in Human Brain using Western Blot

    KCNK10 antibody - N-terminal region (ARP35398_P050)

    Protein Name:Potassium channel subfamily K member 10
    Catalog #:ARP35398_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    KCNQ2 antibody - middle region (ARP35457_P050) in Human NCI-H226 using Western Blot
    KCNQ2 antibody - middle region (ARP35457_P050) in Human Brain using Immunohistochemistry

    KCNQ2 antibody - middle region (ARP35457_P050)

    Protein Name:Potassium voltage-gated channel, KQT-like subfamily, member 2 EMBL AAP35692.1
    Catalog #:ARP35457_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
    Application: IHC, WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    CACNB2 antibody - N-terminal region (ARP36758_P050) in Human HepG2 using Western Blot

    CACNB2 antibody - N-terminal region (ARP36758_P050)

    Protein Name:Voltage-gated calcium channel beta 2 subunit splice variant CavB2cN2 EMBL AAQ97609.1
    Catalog #:ARP36758_P050
    Type: pAb
    Reacts with: Cow, Human, Mouse, Rabbit, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  •  
    TRPC4 antibody - middle region (ARP35256_P050) in Human 293T using Western Blot

    TRPC4 antibody - middle region (ARP35256_P050)

    Protein Name:Short transient receptor potential channel 4
    Catalog #:ARP35256_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat
    Application: IHC, WB
    Product Size: 100 ul
    Price (USD): $289.00
  •  
    TRPM5 antibody - N-terminal region (ARP35242_P050) in Human HepG2 using Western Blot
    TRPM5 antibody - N-terminal region (ARP35242_P050) in Human Pancreas using Immunohistochemistry

    TRPM5 antibody - N-terminal region (ARP35242_P050)

    Protein Name:Transient receptor potential cation channel subfamily M member 5
    Catalog #:ARP35242_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rat
    Application: IHC, WB
    Product Size: 100 ul
    Price (USD): $289.00
  •  
    KCNB1 antibody - middle region (ARP33975_P050) in Human HepG2 using Western Blot

    KCNB1 antibody - middle region (ARP33975_P050)

    Protein Name:Potassium voltage-gated channel subfamily B member 1
    Catalog #:ARP33975_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    BSND antibody - middle region (ARP59578_P050) in Human Heart using Western Blot

    BSND antibody - middle region (ARP59578_P050)

    Protein Name:Barttin
    Catalog #:ARP59578_P050
    Type: pAb
    Reacts with: Human
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    TOMM40L antibody - middle region (ARP35374_P050) in Human HT1080 using Western Blot

    TOMM40L antibody - middle region (ARP35374_P050)

    Protein Name:Mitochondrial import receptor subunit TOM40B
    Catalog #:ARP35374_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  •  
    KCNK1 antibody - middle region (ARP35089_P050) in Human Heart using Western Blot

    KCNK1 antibody - middle region (ARP35089_P050)

    Protein Name:Potassium channel subfamily K member 1
    Catalog #:ARP35089_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  •  
    GABRB2 antibody - N-terminal region (ARP34989_P050) in Human HepG2 using Western Blot

    GABRB2 antibody - N-terminal region (ARP34989_P050)

    Protein Name:Gamma-aminobutyric acid receptor subunit beta-2
    Catalog #:ARP34989_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Sheep, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    SLC25A19 antibody - middle region (ARP44023_P050) in Human HepG2 using Western Blot

    SLC25A19 antibody - middle region (ARP44023_P050)

    Protein Name:Mitochondrial thiamine pyrophosphate carrier
    Catalog #:ARP44023_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Sheep, Yeast
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  •  
    SCN5A antibody - C-terminal region (ARP35542_P050) in Human SW620 using Western Blot
    SCN5A antibody - C-terminal region (ARP35542_P050) in MCF7 Whole Cell using Western Blot

    SCN5A antibody - C-terminal region (ARP35542_P050)

    Protein Name:Sodium channel protein type 5 subunit alpha
    Catalog #:ARP35542_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00

Page of 12

Showing 211 - 240 of 356