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Now Offering Over 85,203 Antibodies & 34,301 Antigens!

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Ion Channel Antibodies

Ion channels are a class of membrane-bound proteins that are present on the surface of all cells as well as on intracellular organelles. Ion channels typically function by creating and maintaining an ion gradient across either cellular or organelle membranes. These channels, comprised of a variety of different protein subunits, contain a pore that can be as narrow as a single atom, allowing for precise control of ion passage.

Ion channels play a critical role in the proper functioning of the human nervous system. Voltage-gated ion channels are present on all neurons and it is the voltage gradient created and maintained by these channels that permits signal propagation; a change in the voltage across the membrane can cause the channel to open or close.

Ion channels, such as those that are present at neuronal synapses, can also be ligand-gated in which the binding of a specific ligand will result in a conformational change in the ion channel resulting in pore opening. In addition to voltage- and ligand-activated ion channels, ion channels can also be activated by heat, temperature, or mechanical stress.

Ion channels have a variety of biological functions, including roles in neuronal signal transmission, muscle contraction, T-cell activation, and insulin release from beta cells. Dysfunctional ion channel activity is the basis of many human diseases. For instance, cystic fibrosis is a result of a genetic mutation in the CFTR gene, which encodes a protein component of a chloride ion channel[1]. Specific natural or synthetic toxins can also affect the functional ability of ion channels; the puffer fish produces tetrodotoxin (TTX), which inhibits the function of sodium channels and can cause respiratory paralysis and death.

1. Rogan, et al. 2011. Cystic fibrosis transmembrane conductance regulator intracellular processing, trafficking, and opportunities for mutation-specific treatment. Chest. 139(6):1480-90.

Ion channels are gated, ion-selective glycoproteins that traverse membranes. The stimulus for channel gating can be a membrane potential, drug, transmitter, cytoplasmic messenger, or a mechanical deformation. We have manufactured products for ~200 human ion channel proteins.

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Showing 211 - 240 of 353
  • TRIAL 
    BTBD10 antibody - N-terminal region (ARP35376_P050) in Human 293T using Western Blot

    BTBD10 antibody - N-terminal region (ARP35376_P050)

    Protein Name:BTB/POZ domain-containing protein 10
    Catalog #:ARP35376_P050
    Type: pAb
    Reacts with: Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    KCTD4 antibody - middle region (ARP36736_P050) in Human Heart using Western Blot

    KCTD4 antibody - middle region (ARP36736_P050)

    Protein Name:BTB/POZ domain-containing protein KCTD4
    Catalog #:ARP36736_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  •  
    Aqp2 antibody - middle region (ARP44295_P050) in Mouse Heart using Western Blot

    Aqp2 antibody - middle region (ARP44295_P050)

    Protein Name:Aquaporin-2
    Catalog #:ARP44295_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rat, Sheep
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    KCNA7 antibody - C-terminal region (ARP35365_P050) in Human Jurkat using Western Blot

    KCNA7 antibody - C-terminal region (ARP35365_P050)

    Protein Name:Potassium voltage-gated channel subfamily A member 7
    Catalog #:ARP35365_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Human, Mouse, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  •  
    KCTD7 antibody - N-terminal region (ARP35422_P050) in Transfected 293T using Western Blot
    KCTD7 antibody - N-terminal region (ARP35422_P050) in Hum. Fetal Heart using Western Blot
    KCTD7 antibody - N-terminal region (ARP35422_P050) in Hum. Fetal Lung using Western Blot
    KCTD7 antibody - N-terminal region (ARP35422_P050) in Hum. Adult Placenta using Western Blot

    KCTD7 antibody - N-terminal region (ARP35422_P050)

    Protein Name:BTB/POZ domain-containing protein KCTD7
    Catalog #:ARP35422_P050
    Type: pAb
    Reacts with: Cow, Dog, Horse, Human, Mouse, Pig, Rabbit, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    CACNB2 antibody - middle region (ARP35594_P050) in Human MCF-7 using Western Blot

    CACNB2 antibody - middle region (ARP35594_P050)

    Protein Name:Calcium channel, voltage-dependent, beta 2 subunit EMBL CAO03605.1
    Catalog #:ARP35594_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  •  
    SCN8A antibody - middle region (ARP35227_P050) in Human Muscle using Western Blot
    SCN8A antibody - middle region (ARP35227_P050) in Human NCI-H226 using Western Blot

    SCN8A antibody - middle region (ARP35227_P050)

    Protein Name:Sodium channel protein type 8 subunit alpha
    Catalog #:ARP35227_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    P2RX4 antibody - N-terminal region (ARP35512_P050) in Human Muscle using Western Blot

    P2RX4 antibody - N-terminal region (ARP35512_P050)

    Protein Name:P2X purinoceptor 4
    Catalog #:ARP35512_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Human, Mouse, Pig, Rabbit, Rat, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    KCNRG antibody - middle region (ARP35502_P050) in Human Heart using Western Blot

    KCNRG antibody - middle region (ARP35502_P050)

    Protein Name:Potassium channel regulatory protein
    Catalog #:ARP35502_P050
    Type: pAb
    Reacts with: Cow, Dog, Horse, Human, Pig, Rabbit
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  •  
    GLRA1 antibody - middle region (AVARP13003_P050) in Human Raji using Western Blot

    GLRA1 antibody - middle region (AVARP13003_P050)

    Protein Name:Glycine receptor subunit alpha-1
    Catalog #:AVARP13003_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  •  
    OSTalpha antibody - middle region (ARP53102_P050) in Human COLO205 using Western Blot

    OSTalpha antibody - middle region (ARP53102_P050)

    Protein Name:Organic solute transporter subunit alpha
    Catalog #:ARP53102_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    CACNB1 antibody - middle region (ARP35580_P050) in Human COLO205 using Western Blot
    CACNB1 antibody - middle region (ARP35580_P050) in Hum. Fetal Muscle using Western Blot
    CACNB1 antibody - middle region (ARP35580_P050) in Hum. Adult Placenta using Western Blot

    CACNB1 antibody - middle region (ARP35580_P050)

    Protein Name:Voltage-dependent L-type calcium channel subunit beta-1
    Catalog #:ARP35580_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    P2RX2 antibody - N-terminal region (ARP35209_P050) in Human OVCAR3 using Western Blot

    P2RX2 antibody - N-terminal region (ARP35209_P050)

    Protein Name:P2X purinoceptor 2
    Catalog #:ARP35209_P050
    Type: pAb
    Reacts with: Human
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  •  
    VDAC3 antibody - N-terminal region (ARP35180_P050) in Human Heart using Western Blot
    VDAC3 antibody - N-terminal region (ARP35180_P050) in Human 721_B using Western Blot
    VDAC3 antibody - N-terminal region (ARP35180_P050) in Hum. Fetal Heart using Western Blot
    VDAC3 antibody - N-terminal region (ARP35180_P050) in Hum. Fetal Muscle using Western Blot

    VDAC3 antibody - N-terminal region (ARP35180_P050)

    Protein Name:Voltage-dependent anion-selective channel protein 3
    Catalog #:ARP35180_P050
    Type: pAb
    Reacts with: Cow, Dog, Goat, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
    Application: IHC, WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    KCNIP2 antibody - middle region (ARP35490_P050) in Human Stomach using Western Blot

    KCNIP2 antibody - middle region (ARP35490_P050)

    Protein Name:Kv channel-interacting protein 2
    Catalog #:ARP35490_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  •  
    FXYD1 antibody - N-terminal region (ARP46562_P050) in Transfected 293T using Western Blot

    FXYD1 antibody - N-terminal region (ARP46562_P050)

    Protein Name:Phospholemman
    Catalog #:ARP46562_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Pig, Rabbit, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  •  
    GABRA5 antibody - middle region (ARP34983_P050) in Human Heart using Western Blot
    GABRA5 antibody - middle region (ARP34983_P050) in Human Liver  using Western Blot

    GABRA5 antibody - middle region (ARP34983_P050)

    Protein Name:Gamma-aminobutyric acid receptor subunit alpha-5
    Catalog #:ARP34983_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    NR6A1 antibody - middle region (ARP45640_P050) in Human THP-1 using Western Blot

    NR6A1 antibody - middle region (ARP45640_P050)

    Protein Name:Nuclear receptor subfamily 6 group A member 1
    Catalog #:ARP45640_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Sheep
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    CACNA1G antibody - C - terminal region (ARP35566_P050) in Human Spleen using Western Blot
    CACNA1G antibody - C - terminal region (ARP35566_P050) in Human brain using Immunohistochemistry

    CACNA1G antibody - C - terminal region (ARP35566_P050)

    Protein Name:Voltage-dependent T-type calcium channel subunit alpha-1G
    Catalog #:ARP35566_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
    Application: IHC, WB
    Product Size: 100 ul
    Price (USD): $289.00
  •  
    ACCN1 antibody - middle region (ARP35537_P050) in Human THP-1 using Western Blot

    ACCN1 antibody - middle region (ARP35537_P050)

    Protein Name:Acid-sensing ion channel 2
    Catalog #:ARP35537_P050
    Type: pAb
    Reacts with: Cow, Dog, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    KCNJ4 antibody - middle region (ARP35167_P050) in Human 293T using Western Blot

    KCNJ4 antibody - middle region (ARP35167_P050)

    Protein Name:Inward rectifier potassium channel 4
    Catalog #:ARP35167_P050
    Type: pAb
    Reacts with: Dog, Guinea Pig, Human, Mouse, Rabbit, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    KCNH6 antibody - middle region (ARP35480_P050) in Human HepG2 using Western Blot

    KCNH6 antibody - middle region (ARP35480_P050)

    Protein Name:Potassium voltage-gated channel subfamily H member 6
    Catalog #:ARP35480_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    KCNH3 antibody - middle region (ARP37688_P050) in Human HeLa using Western Blot

    KCNH3 antibody - middle region (ARP37688_P050)

    Protein Name:Potassium voltage-gated channel subfamily H member 3
    Catalog #:ARP37688_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  •  
    ACCN2 antibody - N-terminal region (ARP35298_P050) in Human MCF7 using Western Blot
    ACCN2 antibody - N-terminal region (ARP35298_P050) in Hum. Fetal Heart using Western Blot
    ACCN2 antibody - N-terminal region (ARP35298_P050) in Hum. Fetal Lung using Western Blot
    ACCN2 antibody - N-terminal region (ARP35298_P050) in Hum. Fetal Liver using Western Blot

    ACCN2 antibody - N-terminal region (ARP35298_P050)

    Protein Name:Acid-sensing ion channel 1
    Catalog #:ARP35298_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  •  
    CHRNA4 antibody - N-terminal region (ARP34965_P050) in Human HepG2 using Western Blot

    CHRNA4 antibody - N-terminal region (ARP34965_P050)

    Protein Name:Neuronal acetylcholine receptor subunit alpha-4
    Catalog #:ARP34965_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    NDNL2 antibody - middle region (ARP57727_P050) in Human Brain using Western Blot

    NDNL2 antibody - middle region (ARP57727_P050)

    Protein Name:Melanoma-associated antigen G1
    Catalog #:ARP57727_P050
    Type: pAb
    Reacts with: Cow, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  •  
    KCNAB1 antibody - C-terminal region (ARP35126_P050) in Human kidney using Western Blot
    KCNAB1 antibody - C-terminal region (ARP35126_P050) in mouse PFC using Immunohistochemistry

    KCNAB1 antibody - C-terminal region (ARP35126_P050)

    Protein Name:Voltage-gated potassium channel subunit beta-1
    Catalog #:ARP35126_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
    Application: IHC, WB
    Product Size: 100 ul
    Price (USD): $289.00
  •  
    KCND3 antibody - middle region (ARP35467_P050) in Human HepG2 using Western Blot

    KCND3 antibody - middle region (ARP35467_P050)

    Protein Name:Potassium voltage-gated channel, Shal-related subfamily, member 3 EMBL AAI13478.1
    Catalog #:ARP35467_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    TRPM3 antibody - N-terminal region (ARP36776_P050) in Human Jurkat using Western Blot

    TRPM3 antibody - N-terminal region (ARP36776_P050)

    Protein Name:
    Catalog #:ARP36776_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    TRPM4 antibody - N-terminal region (ARP35268_P050) in Human 293T using Western Blot
    TRPM4 antibody - N-terminal region (ARP35268_P050) in Human HepG2 using Western Blot
    TRPM4 antibody - N-terminal region (ARP35268_P050) in Human Jurkat using Western Blot
    TRPM4 antibody - N-terminal region (ARP35268_P050) in Human MCF7 using Western Blot

    TRPM4 antibody - N-terminal region (ARP35268_P050)

    Protein Name:Transient receptor potential cation channel subfamily M member 4
    Catalog #:ARP35268_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00

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Showing 211 - 240 of 353