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Aviva Systems Biology office will be closed for Christmas and New Year holidays - 12/24/2014, 12/25/2014 and 1/1/2015.
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Now Offering Over 85,203 Antibodies & 34,301 Antigens!

Ion Channel Antibodies

Ion channels are a class of membrane-bound proteins that are present on the surface of all cells as well as on intracellular organelles. Ion channels typically function by creating and maintaining an ion gradient across either cellular or organelle membranes. These channels, comprised of a variety of different protein subunits, contain a pore that can be as narrow as a single atom, allowing for precise control of ion passage.

Ion channels play a critical role in the proper functioning of the human nervous system. Voltage-gated ion channels are present on all neurons and it is the voltage gradient created and maintained by these channels that permits signal propagation; a change in the voltage across the membrane can cause the channel to open or close.

Ion channels, such as those that are present at neuronal synapses, can also be ligand-gated in which the binding of a specific ligand will result in a conformational change in the ion channel resulting in pore opening. In addition to voltage- and ligand-activated ion channels, ion channels can also be activated by heat, temperature, or mechanical stress.

Ion channels have a variety of biological functions, including roles in neuronal signal transmission, muscle contraction, T-cell activation, and insulin release from beta cells. Dysfunctional ion channel activity is the basis of many human diseases. For instance, cystic fibrosis is a result of a genetic mutation in the CFTR gene, which encodes a protein component of a chloride ion channel[1]. Specific natural or synthetic toxins can also affect the functional ability of ion channels; the puffer fish produces tetrodotoxin (TTX), which inhibits the function of sodium channels and can cause respiratory paralysis and death.

1. Rogan, et al. 2011. Cystic fibrosis transmembrane conductance regulator intracellular processing, trafficking, and opportunities for mutation-specific treatment. Chest. 139(6):1480-90.

Ion channels are gated, ion-selective glycoproteins that traverse membranes. The stimulus for channel gating can be a membrane potential, drug, transmitter, cytoplasmic messenger, or a mechanical deformation. We have manufactured products for ~200 human ion channel proteins.

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  Type Catalog # Product Product Images Price (USD)
  pAb ARP74448_P050 CLIC2 Antibody - N-terminal region (ARP74448_P050)
Reacts with
Human
Application
WB
$289.00
  pAb ARP73793_P050 CLCN6 Antibody - C-terminal region (ARP73793_P050)
Reacts with
Human
Application
WB
$289.00
  pAb ARP74449_P050 CLIC3 Antibody - middle region (ARP74449_P050)
Reacts with
Human
Application
WB
$289.00
  pAb ARP74423_P050 CACNB1 Antibody - middle region (ARP74423_P050)
Reacts with
Human
Application
WB
$289.00
  pAb ARP73792_P050 CLCN4 Antibody - N-terminal region (ARP73792_P050)
Reacts with
Human
Application
WB
$289.00
  pAb ARP73934_P050 CNGB3 Antibody - N-terminal region (ARP73934_P050)
Reacts with
Human
Application
WB
$289.00
  pAb ARP35593_P050 Cacnb2 Antibody - middle region (ARP35593_P050)
Reacts with
Human, Mouse, Rat, Dog, Pig, Horse, Rabbit, Guinea pig, Bovine, Zebrafish
Application
WB
$289.00
  pAb ARP30673_P050 CHRNA6 antibody - N-terminal region (ARP30673_P050)
Reacts with
Human, Dog, Pig, Bovine, Horse, Rabbit, Rat, Mouse
Application
WB
$289.00
  pAb ARP72995_P050 CACNB3 Antibody - C-terminal region (ARP72995_P050)
Reacts with
Human, Dog, Pig, Horse, Rabbit, Rat, Guinea pig, Mouse, Bovine
Application
WB
$289.00
  pAb ARP35189_P050 Cacng2 antibody - middle region (ARP35189_P050)
Reacts with
Bovine, Zebrafish, Pig, Horse, Rabbit, Rat, Guinea pig, Dog, Mouse, Human
Application
WB
$289.00
  pAb AVARP13015_P050 CHRNA4 antibody - N-terminal region (AVARP13015_P050)
Reacts with
Bovine, Guinea pig, Human, Mouse, Rabbit, Rat
Application
WB
$289.00
  pAb ARP34916_P050 CLCNKB antibody - N-terminal region (ARP34916_P050)
Reacts with
Human, Horse, Mouse, Bovine, Rat, Guinea pig, Rabbit, Dog
Application
WB
$289.00
  pAb ARP34914_P050 Clcn5 antibody - middle region (ARP34914_P050)
Reacts with
Sheep, Human, Mouse, Bovine, Dog, Horse, Rabbit, Guinea pig, Rat, Zebrafish
Application
WB
$289.00
  pAb ARP36758_P050 CACNB2 antibody - N-terminal region (ARP36758_P050)
Reacts with
Human, Mouse, Rabbit, Rat, Bovine
Application
WB
$289.00
  pAb ARP35594_P050 CACNB2 antibody - middle region (ARP35594_P050)
Reacts with
Human, Mouse, Pig, Horse, Bovine, Rat, Dog, Rabbit, Guinea pig, Zebrafish
Application
WB
$289.00
  pAb ARP35566_P050 CACNA1G antibody - C - terminal region (ARP35566_P050)
Reacts with
Human, Dog, Horse, Rabbit, Mouse, Rat, Bovine, Pig, Guinea pig
Application
IHC, WB
$289.00
  pAb ARP34952_P050 CACNA2D1 antibody - middle region (ARP34952_P050)
Reacts with
Rat, Mouse, Bovine, Dog, Horse, Rabbit, Guinea pig, Human
Application
WB
$289.00
  pAb ARP35602_P050 CACNB2 antibody - middle region (ARP35602_P050)
Reacts with
Human
Application
WB
$289.00
  pAb ARP36765_P050 CACNB2 antibody - N-terminal region (ARP36765_P050)
Reacts with
Human
Application
WB
$289.00
  pAb ARP35600_P050 CACNB2 antibody - middle region (ARP35600_P050)
Reacts with
Mouse, Zebrafish, Human, Rat, Dog, Bovine, Pig, Horse, Rabbit, Guinea pig
Application
WB
$289.00
  pAb ARP35580_P050 CACNB1 antibody - middle region (ARP35580_P050)
Reacts with
Mouse, Zebrafish, Human, Rat, Dog, Bovine, Pig, Horse, Rabbit, Guinea pig
Application
WB
$289.00
  pAb ARP35388_P050 CLIC6 antibody - middle region (ARP35388_P050)
Reacts with
Rat, Rabbit, Pig, Mouse, Human
Application
WB
$289.00
  pAb ARP35132_P050 CLCNKA antibody - N-terminal region (ARP35132_P050)
Reacts with
Human, Bovine, Mouse, Rat, Pig
Application
WB
$289.00
  pAb ARP34954_P050 CACNB1 antibody - N-terminal region (ARP34954_P050)
Reacts with
Human, Dog, Pig, Bovine, Horse, Rat, Guinea pig, Mouse, Rabbit, Zebrafish
Application
WB
$289.00
  pAb AVARP13100_P050 CHRNA6 Antibody - N-terminal region (AVARP13100_P050)
Reacts with
Dog, Human, Mouse, Rat
Application
WB
$289.00
  pAb ARP34910_P050 CHRNA1 antibody - N-terminal region (ARP34910_P050)
Reacts with
Human, Dog, Pig, Horse, Rabbit, Guinea pig, Bovine, Mouse, Rat
Application
WB
$289.00
  pAb AVARP13014_P050 CHRNA3 antibody - N-terminal region (AVARP13014_P050)
Reacts with
Bovine, Dog, Guinea pig, Human, Mouse, Rabbit, Rat
Application
WB
$289.00
  pAb ARP34966_P050 CHRNA5 antibody - middle region (ARP34966_P050)
Reacts with
Human, Rabbit, Rat, Mouse, Pig, Horse, Bovine, Dog
Application
WB
$289.00
  pAb ARP36744_P050 CACNB1 antibody - C-terminal region (ARP36744_P050)
Reacts with
Mouse, Human, Zebrafish, Bovine, Rabbit, Guinea pig
Application
WB
$289.00
  pAb ARP35592_P050 CACNB2 antibody - middle region (ARP35592_P050)
Reacts with
Human, Mouse, Rat, Horse, Rabbit, Bovine, Guinea pig, Dog
Application
WB
$289.00

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Showing 1 - 30 of 54