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Ion Channel Antibodies

Ion channels are a class of membrane-bound proteins that are present on the surface of all cells as well as on intracellular organelles. Ion channels typically function by creating and maintaining an ion gradient across either cellular or organelle membranes. These channels, comprised of a variety of different protein subunits, contain a pore that can be as narrow as a single atom, allowing for precise control of ion passage.

Ion channels play a critical role in the proper functioning of the human nervous system. Voltage-gated ion channels are present on all neurons and it is the voltage gradient created and maintained by these channels that permits signal propagation; a change in the voltage across the membrane can cause the channel to open or close.

Ion channels, such as those that are present at neuronal synapses, can also be ligand-gated in which the binding of a specific ligand will result in a conformational change in the ion channel resulting in pore opening. In addition to voltage- and ligand-activated ion channels, ion channels can also be activated by heat, temperature, or mechanical stress.

Ion channels have a variety of biological functions, including roles in neuronal signal transmission, muscle contraction, T-cell activation, and insulin release from beta cells. Dysfunctional ion channel activity is the basis of many human diseases. For instance, cystic fibrosis is a result of a genetic mutation in the CFTR gene, which encodes a protein component of a chloride ion channel[1]. Specific natural or synthetic toxins can also affect the functional ability of ion channels; the puffer fish produces tetrodotoxin (TTX), which inhibits the function of sodium channels and can cause respiratory paralysis and death.

1. Rogan, et al. 2011. Cystic fibrosis transmembrane conductance regulator intracellular processing, trafficking, and opportunities for mutation-specific treatment. Chest. 139(6):1480-90.

Ion channels are gated, ion-selective glycoproteins that traverse membranes. The stimulus for channel gating can be a membrane potential, drug, transmitter, cytoplasmic messenger, or a mechanical deformation. We have manufactured products for ~200 human ion channel proteins.

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Showing 1 - 30 of 60
  • TRIAL 
    CHRNA6 antibody - N-terminal region (ARP30673_P050) in Human Jurkat using Western Blot

    CHRNA6 antibody - N-terminal region (ARP30673_P050)

    Protein Name:Neuronal acetylcholine receptor subunit alpha-6
    Catalog #:ARP30673_P050
    Type: pAb
    Reacts with: Cow, Dog, Horse, Human, Mouse, Pig, Rabbit, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    Cacng2 antibody - middle region (ARP35189_P050) in Rat Liver using Western Blot

    Cacng2 antibody - middle region (ARP35189_P050)

    Protein Name:IPR328 protein EMBL AAK08653.1
    Catalog #:ARP35189_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    CACNB3 Antibody - C-terminal region (ARP72995_P050) in Human Hela using Western Blot

    CACNB3 Antibody - C-terminal region (ARP72995_P050)

    Protein Name:
    Catalog #:ARP72995_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    Cacnb2 Antibody - middle region (ARP35593_P050) in Rat Thymus using Western Blot

    Cacnb2 Antibody - middle region (ARP35593_P050)

    Protein Name:
    Catalog #:ARP35593_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  •  
    CACNA2D1 antibody - middle region (ARP34952_P050) in Human Muscle using Western Blot
    CACNA2D1 antibody - middle region (ARP34952_P050) in Fetal Muscle using Western Blot

    CACNA2D1 antibody - middle region (ARP34952_P050)

    Protein Name:Voltage-dependent calcium channel subunit alpha-2/delta-1
    Catalog #:ARP34952_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    CACNB2 antibody - middle region (ARP35602_P050) in Human Lung using Western Blot

    CACNB2 antibody - middle region (ARP35602_P050)

    Protein Name:Voltage-gated calcium channel beta 2 subunit splice variant CavB2cN1 EMBL AAQ97608.1
    Catalog #:ARP35602_P050
    Type: pAb
    Reacts with: Human
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    CACNB2 antibody - N-terminal region (ARP36765_P050) in Human HepG2 using Western Blot

    CACNB2 antibody - N-terminal region (ARP36765_P050)

    Protein Name:Voltage-dependent L-type calcium channel subunit beta-2
    Catalog #:ARP36765_P050
    Type: pAb
    Reacts with: Human
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    CACNB2 antibody - middle region (ARP35600_P050) in Human Thymus using Western Blot

    CACNB2 antibody - middle region (ARP35600_P050)

    Protein Name:Voltage-dependent L-type calcium channel subunit beta-2
    Catalog #:ARP35600_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    CACNB1 antibody - middle region (ARP35580_P050) in Human COLO205 using Western Blot
    CACNB1 antibody - middle region (ARP35580_P050) in Hum. Fetal Muscle using Western Blot
    CACNB1 antibody - middle region (ARP35580_P050) in Hum. Adult Placenta using Western Blot

    CACNB1 antibody - middle region (ARP35580_P050)

    Protein Name:Voltage-dependent L-type calcium channel subunit beta-1
    Catalog #:ARP35580_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    CLIC6 antibody - middle region (ARP35388_P050) in Human Jurkat using Western Blot

    CLIC6 antibody - middle region (ARP35388_P050)

    Protein Name:Chloride intracellular channel protein 6
    Catalog #:ARP35388_P050
    Type: pAb
    Reacts with: Human, Mouse, Pig, Rabbit, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    CLCNKA antibody - N-terminal region (ARP35132_P050) in Human Liver using Western Blot

    CLCNKA antibody - N-terminal region (ARP35132_P050)

    Protein Name:Chloride channel protein ClC-Ka
    Catalog #:ARP35132_P050
    Type: pAb
    Reacts with: Cow, Human, Mouse, Pig, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    CACNB1 antibody - N-terminal region (ARP34954_P050) in Human Brain using Western Blot

    CACNB1 antibody - N-terminal region (ARP34954_P050)

    Protein Name:Voltage-dependent L-type calcium channel subunit beta-1
    Catalog #:ARP34954_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  •  
    CHRNA6 Antibody - N-terminal region (AVARP13100_P050) in Human THP-1 using Western Blot

    CHRNA6 Antibody - N-terminal region (AVARP13100_P050)

    Protein Name:Neuronal acetylcholine receptor subunit alpha-6
    Catalog #:AVARP13100_P050
    Type: pAb
    Reacts with: Dog, Human, Mouse, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    CHRNA1 antibody - N-terminal region (ARP34910_P050) in Human kidney using Western Blot

    CHRNA1 antibody - N-terminal region (ARP34910_P050)

    Protein Name:Cholinergic receptor, nicotinic, alpha 1 (Muscle), isoform CRA_a EMBL EAX11124.1
    Catalog #:ARP34910_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  •  
    CHRNA3 antibody - N-terminal region (AVARP13014_P050) in Human Thymus using Western Blot

    CHRNA3 antibody - N-terminal region (AVARP13014_P050)

    Protein Name:Neuronal acetylcholine receptor subunit alpha-3
    Catalog #:AVARP13014_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Human, Mouse, Rabbit, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    CHRNA5 antibody - middle region (ARP34966_P050) in Human Spleen using Western Blot

    CHRNA5 antibody - middle region (ARP34966_P050)

    Protein Name:Neuronal acetylcholine receptor subunit alpha-5
    Catalog #:ARP34966_P050
    Type: pAb
    Reacts with: Cow, Dog, Horse, Human, Mouse, Pig, Rabbit, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    CACNB1 antibody - C-terminal region (ARP36744_P050) in Human MCF-7 using Western Blot

    CACNB1 antibody - C-terminal region (ARP36744_P050)

    Protein Name:Voltage-dependent L-type calcium channel subunit beta-1
    Catalog #:ARP36744_P050
    Type: pAb
    Reacts with: Cow, Guinea Pig, Human, Mouse, Rabbit, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    CACNB2 antibody - middle region (ARP35592_P050) in Human kidney using Western Blot

    CACNB2 antibody - middle region (ARP35592_P050)

    Protein Name:Voltage-dependent L-type calcium channel subunit beta-2
    Catalog #:ARP35592_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00

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Showing 1 - 30 of 60