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Now Offering Over 85,203 Antibodies & 34,301 Antigens!

Ion Channel Antibodies

Ion channels are a class of membrane-bound proteins that are present on the surface of all cells as well as on intracellular organelles. Ion channels typically function by creating and maintaining an ion gradient across either cellular or organelle membranes. These channels, comprised of a variety of different protein subunits, contain a pore that can be as narrow as a single atom, allowing for precise control of ion passage.

Ion channels play a critical role in the proper functioning of the human nervous system. Voltage-gated ion channels are present on all neurons and it is the voltage gradient created and maintained by these channels that permits signal propagation; a change in the voltage across the membrane can cause the channel to open or close.

Ion channels, such as those that are present at neuronal synapses, can also be ligand-gated in which the binding of a specific ligand will result in a conformational change in the ion channel resulting in pore opening. In addition to voltage- and ligand-activated ion channels, ion channels can also be activated by heat, temperature, or mechanical stress.

Ion channels have a variety of biological functions, including roles in neuronal signal transmission, muscle contraction, T-cell activation, and insulin release from beta cells. Dysfunctional ion channel activity is the basis of many human diseases. For instance, cystic fibrosis is a result of a genetic mutation in the CFTR gene, which encodes a protein component of a chloride ion channel[1]. Specific natural or synthetic toxins can also affect the functional ability of ion channels; the puffer fish produces tetrodotoxin (TTX), which inhibits the function of sodium channels and can cause respiratory paralysis and death.

1. Rogan, et al. 2011. Cystic fibrosis transmembrane conductance regulator intracellular processing, trafficking, and opportunities for mutation-specific treatment. Chest. 139(6):1480-90.

Ion channels are gated, ion-selective glycoproteins that traverse membranes. The stimulus for channel gating can be a membrane potential, drug, transmitter, cytoplasmic messenger, or a mechanical deformation. We have manufactured products for ~200 human ion channel proteins.

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Showing 1 - 30 of 306
  Type Catalog # Product Product Images Price (USD)
  pAb ARP74448_P050 CLIC2 Antibody - N-terminal region (ARP74448_P050)
Reacts with
Human
Application
WB
$289.00
  pAb ARP73793_P050 CLCN6 Antibody - C-terminal region (ARP73793_P050)
Reacts with
Human
Application
WB
$289.00
  pAb ARP73934_P050 CNGB3 Antibody - N-terminal region (ARP73934_P050)
Reacts with
Human
Application
WB
$289.00
  pAb ARP72463_P050 KCTD15 Antibody - N-terminal region (ARP72463_P050)
Reacts with
Human
Application
WB
$289.00
  pAb ARP74449_P050 CLIC3 Antibody - middle region (ARP74449_P050)
Reacts with
Human
Application
WB
$289.00
  pAb ARP74423_P050 CACNB1 Antibody - middle region (ARP74423_P050)
Reacts with
Human
Application
WB
$289.00
  pAb ARP73792_P050 CLCN4 Antibody - N-terminal region (ARP73792_P050)
Reacts with
Human
Application
WB
$289.00
  pAb ARP73928_P050 ACHA6 Antibody - middle region (ARP73928_P050)
Reacts with
Human
Application
WB
$289.00
  pAb ARP35328_P050 NMDZ1 Antibody - middle region (ARP35328_P050)
Reacts with
Human
Application
WB
$289.00
  pAb ARP34985_P050 GBRA6 Antibody - N-terminal region (ARP34985_P050)
Reacts with
Human
Application
WB
$289.00
  pAb ARP35157_P050 KCNB1 Antibody - C-terminal region (ARP35157_P050)
Reacts with
Human
Application
WB
$289.00
  pAb ARP34969_P050 ACHB Antibody - N-terminal region (ARP34969_P050)
Reacts with
Human
Application
WB
$289.00
  pAb ARP35083_P050 KCNJ6 Antibody - C-terminal region (ARP35083_P050)
Reacts with
Human
Application
WB
$289.00
  pAb ARP34996_P050 GLRB Antibody - N-terminal region (ARP34996_P050)
Reacts with
Human
Application
WB
$289.00
  pAb ARP30691_P050 GABRB3 Antibody - middle region (ARP30691_P050)
Reacts with
Bovine, Human, Rat, Horse, Rabbit, Guinea pig, Dog, Mouse
Application
WB
$289.00
  pAb ARP35478_P050 KCNH5 antibody - N-terminal region (ARP35478_P050)
Reacts with
Zebrafish, Bovine, Dog, Horse, Rabbit, Rat, Guinea pig, Human, Mouse
Application
IHC, WB
$289.00
  pAb ARP35339_P050 GABRB3 antibody - middle region (ARP35339_P050)
Reacts with
Bovine, Human, Rat, Horse, Rabbit, Guinea pig, Dog, Mouse, Zebrafish
Application
IHC, WB
$289.00
  pAb ARP35097_P050 KCNN3 antibody - C-terminal region (ARP35097_P050)
Reacts with
Bovine, Dog, Pig, Rabbit, Rat, Guinea pig, Mouse, Human, Horse
Application
IHC, WB
$289.00
  pAb ARP35763_P050 Dlx6 antibody - C-terminal region (ARP35763_P050)
Reacts with
Rat, Dog, Bovine, Horse, Rabbit, Human, Guinea pig, Mouse, Zebrafish
Application
WB
$289.00
  pAb ARP35168_P050 KCNJ11 Antibody - middle region (ARP35168_P050)
Reacts with
Human, Pig, Horse, Rat, Guinea pig, Dog, Mouse, Bovine, Rabbit, Zebrafish
Application
WB
$289.00
  pAb ARP35213_P050 KCNH3 antibody - N-terminal region (ARP35213_P050)
Reacts with
Mouse, Human, Bovine, Guinea pig, Rat, Horse, Rabbit, Dog, Zebrafish
Application
WB
$289.00
  pAb ARP35402_P050 Kctd12 Antibody - C-terminal region (ARP35402_P050)
Reacts with
Human, Dog, Pig, Horse, Rabbit, Bovine, Mouse, Zebrafish, Rat, Guinea pig
Application
WB
$289.00
  pAb ARP36738_P050 GABRG2 Antibody - N-terminal region (ARP36738_P050)
Reacts with
Dog, Human, Bovine, Pig, Horse, Rabbit, Rat, Guinea pig, Mouse
Application
WB
$289.00
  pAb ARP49129_P050 Sult1c2 antibody - middle region (ARP49129_P050)
Reacts with
Human, Dog, Horse, Rat, Guinea pig, Rabbit, Bovine, Mouse
Application
WB
$289.00
  pAb ARP32628_P050 NR4A1 antibody - C-terminal region (ARP32628_P050)
Reacts with
Human, Horse, Rabbit, Rat, Dog, Mouse, Guinea pig, Bovine, Zebrafish
Application
WB
$289.00
  pAb ARP72995_P050 CACNB3 Antibody - C-terminal region (ARP72995_P050)
Reacts with
Human, Dog, Pig, Horse, Rabbit, Rat, Guinea pig, Mouse, Bovine
Application
WB
$289.00
  pAb ARP35286_P050 Kcnj16 Antibody - C-terminal region (ARP35286_P050)
Reacts with
Human, Dog, Horse, Rabbit, Rat, Bovine, Mouse, Guinea pig
Application
WB
$289.00
  pAb ARP42079_P050 Rasa1 antibody - C-terminal region (ARP42079_P050)
Reacts with
Human, Mouse, Dog, Pig, Horse, Rabbit, Rat, Guinea pig, Bovine, Zebrafish
Application
WB
$289.00
  pAb ARP34979_P050 GABRA2 Antibody - C-terminal region (ARP34979_P050)
Reacts with
Human, Rat, Bovine, Dog, Horse, Rabbit, Guinea pig, Mouse, Zebrafish
Application
WB
$289.00
  pAb ARP35254_P050 Kctd3 antibody - middle region (ARP35254_P050)
Reacts with
Human, Rat, Dog, Zebrafish, Pig, Horse, Rabbit, Guinea pig, Bovine, Mouse
Application
WB
$289.00

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Showing 1 - 30 of 306