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Aviva Systems Biology

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Now Offering Over 85,203 Antibodies & 34,301 Antigens!

Ion Channel Antibodies

Ion channels are a class of membrane-bound proteins that are present on the surface of all cells as well as on intracellular organelles. Ion channels typically function by creating and maintaining an ion gradient across either cellular or organelle membranes. These channels, comprised of a variety of different protein subunits, contain a pore that can be as narrow as a single atom, allowing for precise control of ion passage.

Ion channels play a critical role in the proper functioning of the human nervous system. Voltage-gated ion channels are present on all neurons and it is the voltage gradient created and maintained by these channels that permits signal propagation; a change in the voltage across the membrane can cause the channel to open or close.

Ion channels, such as those that are present at neuronal synapses, can also be ligand-gated in which the binding of a specific ligand will result in a conformational change in the ion channel resulting in pore opening. In addition to voltage- and ligand-activated ion channels, ion channels can also be activated by heat, temperature, or mechanical stress.

Ion channels have a variety of biological functions, including roles in neuronal signal transmission, muscle contraction, T-cell activation, and insulin release from beta cells. Dysfunctional ion channel activity is the basis of many human diseases. For instance, cystic fibrosis is a result of a genetic mutation in the CFTR gene, which encodes a protein component of a chloride ion channel[1]. Specific natural or synthetic toxins can also affect the functional ability of ion channels; the puffer fish produces tetrodotoxin (TTX), which inhibits the function of sodium channels and can cause respiratory paralysis and death.

1. Rogan, et al. 2011. Cystic fibrosis transmembrane conductance regulator intracellular processing, trafficking, and opportunities for mutation-specific treatment. Chest. 139(6):1480-90.

Ion channels are gated, ion-selective glycoproteins that traverse membranes. The stimulus for channel gating can be a membrane potential, drug, transmitter, cytoplasmic messenger, or a mechanical deformation. We have manufactured products for ~200 human ion channel proteins.

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Showing 1 - 30 of 294
  Type Catalog # Product Product Images Price (USD)
  pAb ARP30673_P050 CHRNA6 antibody - N-terminal region (ARP30673_P050)
Reacts with
Human, Dog, Pig, Bovine, Horse, Rabbit, Rat, Mouse
Application
WB
$289.00
  pAb ARP30687_P050 Gabra5 antibody - middle region (ARP30687_P050)
Reacts with
Human, Dog, Pig, Horse, Rabbit, Rat, Guinea pig, Bovine, Mouse
Application
WB
$289.00
  pAb ARP30689_P050 GABRB1 antibody - middle region (ARP30689_P050)
Reacts with
Human, Dog, Horse, Rabbit, Pig, Bovine, Rat, Mouse
Application
WB
$289.00
  pAb ARP30691_P050 GABRB3 Antibody - middle region (ARP30691_P050)
Reacts with
Bovine, Human, Rat, Horse, Rabbit, Guinea pig, Dog, Mouse
Application
WB
$289.00
  pAb ARP30691_T100 GABRB3 Antibody - middle region (ARP30691_T100)
Reacts with
Bovine, Human, Rat, Horse, Rabbit, Guinea pig, Dog, Mouse
Application
WB
$229.00
  pAb ARP30697_P050 GABRR1 antibody - N-terminal region (ARP30697_P050)
Reacts with
Human, Rat, Guinea pig, Rabbit
Application
WB
$289.00
  pAb ARP31090_P050 NR3C1 antibody - N-terminal region (ARP31090_P050)
Reacts with
Human, Rabbit, Rat, Sheep, Mouse, Bovine, Pig, Horse
Application
WB
$289.00
  pAb ARP32597_P050 GRM6 antibody - C-terminal region (ARP32597_P050)
Reacts with
Yeast, Bovine, Dog, Pig, Horse, Rabbit, Rat, Guinea pig, Human, Mouse, Zebrafish
Application
WB
$289.00
  pAb ARP32628_P050 NR4A1 antibody - C-terminal region (ARP32628_P050)
Reacts with
Human, Horse, Rabbit, Rat, Dog, Mouse, Guinea pig, Bovine, Zebrafish
Application
WB
$289.00
  pAb ARP33492_P050 SF1 antibody - N-terminal region (ARP33492_P050)
Reacts with
Bovine, Horse, Zebrafish, Rabbit, Human, Mouse, Dog, Rat, Pig, Guinea pig, Yeast, Goat
Application
WB
$289.00
  pAb ARP33811_P050 A1BG antibody - C-terminal region (ARP33811_P050)
Reacts with
Human, Mouse, Rat, Dog, Rabbit
Application
WB
$289.00
  pAb ARP33975_P050 KCNB1 antibody - middle region (ARP33975_P050)
Reacts with
Human, Dog, Pig, Bovine, Horse, Rat, Guinea pig, Mouse
Application
WB
$289.00
  pAb ARP33977_P050 KCNA5 antibody - N-terminal region (ARP33977_P050)
Reacts with
Human, Rat, Mouse
Application
WB
$289.00
  pAb ARP34352_P050 SOX1 antibody - C-terminal region (ARP34352_P050)
Reacts with
Dog, Rabbit, Human, Mouse, Bovine
Application
WB
$289.00
  pAb ARP34622_P050 KCNIP4 antibody - N-terminal region (ARP34622_P050)
Reacts with
Rabbit, Rat, Mouse, Human, Dog, Bovine
Application
IHC, WB
$289.00
  pAb ARP34909_P050 CHRNA1 antibody - N-terminal region (ARP34909_P050)
Reacts with
Human, Dog, Pig, Horse, Rabbit, Rat, Bovine, Guinea pig, Mouse
Application
WB
$289.00
  pAb ARP34910_P050 CHRNA1 antibody - N-terminal region (ARP34910_P050)
Reacts with
Human, Dog, Pig, Horse, Rabbit, Guinea pig, Bovine, Mouse, Rat
Application
WB
$289.00
  pAb ARP34912_P050 Clcn1 antibody - C-terminal region (ARP34912_P050)
Reacts with
Horse, Rat, Human, Bovine, Mouse, Rabbit, Goat, Guinea pig, Dog
Application
WB
$289.00
  pAb ARP34914_P050 Clcn5 antibody - middle region (ARP34914_P050)
Reacts with
Sheep, Human, Mouse, Bovine, Dog, Horse, Rabbit, Guinea pig, Rat, Zebrafish
Application
WB
$289.00
  pAb ARP34916_P050 CLCNKB antibody - N-terminal region (ARP34916_P050)
Reacts with
Human, Horse, Mouse, Bovine, Rat, Guinea pig, Rabbit, Dog
Application
WB
$289.00
  pAb ARP34917_P050 CLCNKB antibody - C-terminal region (ARP34917_P050)
Reacts with
Human, Bovine, Pig, Horse, Rabbit, Rat, Mouse, Dog, Guinea pig
Application
WB
$289.00
  pAb ARP34923_P050 KCNA1 antibody - middle region (ARP34923_P050)
Reacts with
Dog, Pig, Human, Rat, Mouse, Horse, Guinea pig
Application
WB
$289.00
  pAb ARP34930_P050 PKD2 Antibody - N-terminal region (ARP34930_P050)
Reacts with
Rabbit, Rat, Guinea pig, Mouse, Human, Bovine, Dog, Horse
Application
WB
$289.00
  pAb ARP34934_P050 SCN5A antibody - N-terminal region (ARP34934_P050)
Reacts with
Rat, Human, Rabbit, Mouse, Bovine, Dog, Pig, Horse, Guinea pig, Zebrafish
Application
WB
$289.00
  pAb ARP34935_P050 SCN5A Antibody - C-terminal region (ARP34935_P050)
Reacts with
Human, Rat, Guinea pig, Bovine, Dog, Horse, Mouse
Application
WB
$289.00
  pAb ARP34936_P050 SCNN1B antibody - C-terminal region (ARP34936_P050)
Reacts with
Bovine, Human, Dog, Goat, Pig, Guinea pig, Rabbit, Horse, Mouse, Rat
Application
WB
$289.00
  pAb ARP34952_P050 CACNA2D1 antibody - middle region (ARP34952_P050)
Reacts with
Rat, Mouse, Bovine, Dog, Horse, Rabbit, Guinea pig, Human
Application
WB
$289.00
  pAb ARP34953_P050 CACNB1 antibody - N-terminal region (ARP34953_P050)
Reacts with
Mouse, Zebrafish, Human, Dog, Pig, Bovine, Horse, Rabbit, Rat, Guinea pig
Application
WB
$289.00
  pAb ARP34954_P050 CACNB1 antibody - N-terminal region (ARP34954_P050)
Reacts with
Human, Dog, Pig, Bovine, Horse, Rat, Guinea pig, Mouse, Rabbit, Zebrafish
Application
WB
$289.00
  pAb ARP34959_P050 CACNB4 antibody - C-terminal region (ARP34959_P050)
Reacts with
Mouse, Zebrafish, Human, Rat, Dog, Bovine, Horse, Rabbit, Guinea pig
Application
WB
$289.00

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Showing 1 - 30 of 294