- Description of Target:
- ESR1 is an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative splicing results in several transcript variants, which differ in their 5' UTRs and use different promoters.
- Gene Symbol:
- Official Gene Full Name:
- Estrogen receptor 1
- NCBI Gene Id:
- Alias Symbols:
- DKFZp686N23123; ER; ESR; ESRA; Era; NR3A1
- Tissue Tool:
- Find tissues and cell lines supported to express ESR1.
- Protein Accession #:
- Nucleotide Accession#:
- Swissprot Id:
- Protein Name:
- Estrogen receptor
- Protein Size (# AA):
- Molecular Weight:
- Partner Proteins:
- ANP32A, AXIN2, BCAS2, BLOC1S1, CCND1, CHUK, CTNNB1, DDX17, DDX5, EBAG9, EIF3I, EP300, ESR2, HDAC1, JUN, JUNB, KDM5A, MED1, MPG, MYC, NCOA1, NCOA2, NCOA3, NCOA3, NCOR1, NCOR2, NRIP1, PGR, PGR, PHB2, PRMT2, RBM23, STAT5A, TFF1, TFF1, TP53, TRIM24, TRRAP, AP1B1, ASCC2, BAGE3, C21orf129, CELSR1, CSNK1E, CYB5R3, DSCAM, FHL2, LOC441967, NCAM2, NRIP1, PIAS1, SFI1, SLC37A1, SNAP29, SOD1, TFF1, TFF1, THOC5, UBE2I, XBP1, AHR, AKAP13, AKT1, AKT2, AR, ARHGEF15, ARNT, BAG1, BCAR1, BCAS2, BDNF, BRCA1, CALM1, CALM3, CALM3, CAV1, CCND1, CCNH, CCNT1, CDC25B, CDK7, CEBPB, CHD9, CHUK, CITED1, COBRA1, COPS5, CREBBP, CSNK2B, CTNNB1, CUEDC2, CUL4B, DDX5, DDX54, DNTTIP2, DUT, EGFR, EIF3I, EP300, ERBB2, ESR1, ESR2, ESRRA, FHL2, FLII, FOXO1, FOXO3, FOXO4, GADD45B, GADD45G, GNAI1, GRB2, GTF2B, GTF2H1, HEXIM1, HNF4A, HSP90AA1, HSP90AB1, HSPA4, IGF1R, ISL1, ITGB3BP, JUN, JUNB, JUND, KAT5, KDM5A, KIF1A, LCK, LOH3CR2A, MAPK1, MAPK14, MAPK3, MDM2, MED1, MED24, MKNK2, MLL2, MMS19, MNAT1, MPG, MTA1, MTCH2, MVP, NCOA1, NCOA2, NCOA3, NCOA6, NCOA7, NCOR1, NCOR2, NFKB1, NPPA, NR0B1, NR0B2, NR1H4, NR2C1, NR2C2, NR2F1, NR2F6, NRIP1, NSD1, PAK1, PAK6, PELP1, PGR, PHB2, PIAS1, PIAS3, PIK3R1, PIK3R3, PNRC2, POLR1B, POLR2D, POU2F1, POU4F1, POU4F2, PPARGC1A, PPARGC1B, PRDM2, PRKACA, PRMT1, PRMT2, PSMC5, PTGES3, PTPN1, PTPN6, RARA, RBFOX2, RBM23, RBM39, RELA, REXO4, RFX4, RGS3, RNF14, RNF4, RPS6KA1, RPS6KA3, RXRA, SAFB, SAFB2, SHC1, SLC30A9, SMAD2, SMAD3, SMAD4, SMARCA2, SMARCA4, SMARCD3, SMARCE1, SOS1, SP1, SP3, SRC, SREBF1, STAT5A, STRN, STUB1, TAF10, TAP1, TBP, TCF20, TDG, THRA, THRB, TNFRSF14, TP53, TRIM24, TRIM28, TRIM59, TRIP4, TRRAP, TSC2, TUBA1B, TUBB, UBE2I, USF1, WIPI1, XBP1, YWHAH, ZBTB16, ZBTB17, ZNF398, AHR, AHRR, AKAP13, ATAD2, BAG1, BAZ1B, BRCA1, CAV1, CCNC, CCND1, CCNH, CDC25B, CDK7, CDK8, CDKN1A, CEBPA, CEBPB, CITED1, COBRA1, CREBBP, CTNNB1, DAP3, DDX17, DDX5, DDX54, DNTTIP2, EP300, ESR1, ESR2, FKBP4, FKBP5, FLII, FOXO1, FOXO4, GADD45A, GADD45G, GRIP1, GTF2H1, Gadd45b, HDAC1, HDAC4, HDAC5, HDAC7, HDAC9, HSP90AA1, HSPA4, HSPA8, IGF1R, ING1, IRS1, IRS2, ISL1, JUN, KAT2A, KAT5, KDM5A, KLF5, LCOR, LDB1, LMO4, MAPK1, MDM2, MED1, MED10, MED12, MED13, MED14, MED16, MED17, MED20, MED21, MED23, MED24, MED6, MED7, MEN1, MGMT, MNAT1, MSH2, MSH6, MTA1, MTA2, MUC1, MVP, MYC, MYOD1, NCOA1, NCOA2, NCOA3, NCOA4, NCOA6, NCOA7, NCOR1, NGG1, NR0B2, NR2C1, NR2C2, NR2F1, NR2F6, NRIP1, Nr0b2, Nr1i2, Nsd1, PAK6, PARP1, PDLIM1, PELP1, PGC, PHB2, PIAS2, PIK3R1, POU2F1, POU2F2, POU4F1, POU4F2, PPARGC1A, PPARGC1B, PPID, PRDM2, PRKDC, PRMT1, PRMT2, PTEN, PTGES3, PTMA, RBBP4, RBBP7, RBFOX2, RBM39, RELA, REXO4, RLIM, RNF4, RPS6KA1, SAFB, SAFB2, SETD7, SHC1, SIN3A, SMAD2, SMARCA2, SMARCA4, SMARCD1, SMARCE1, SMYD3, SP1, SP2, SP3, SRA1, SRC, STAT3, STAT5A, STUB1, SUMO1, SVIL, TADA3, TAF1A, TAF1B, TBP, TDG, TOP2B, TP53, TRAM1, TRIM24, TRIM25, TRIP4, TRRAP, Tada3, UBC, UBE3A, XBP1, XRCC5, XRCC6, YWHAQ, ZBTB16, ZNF398
- The immunogen for anti-ESR1 antibody: synthetic peptide directed towards the C terminal of human ESR1
- Product Format:
- Lyophilized powder
- Complete computational species homology data:
- ESR1 antibody - C-terminal region (ARP31088_P050)
- Predicted Homology Based on Immunogen Sequence:
- Human: 100%
- Species Reactivity:
- Datasheets / Downloads:
- Printable datasheet for
anti-ESR1 antibody- ARP31088_P050
- Peptide Sequence:
- Synthetic peptide located within the following region: AHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV
- Blocking Peptide:
- For anti-ESR1 antibody is Catalog # AAP31088
- Key Reference:
- Reconstitution and Storage:
- Add 50 ul of distilled water. Final anti-ESR1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles.
Aviva Systems Biology is the original manufacturer of this ESR1 antibody (ARP31088_P050)
Click here to view the ESR1 antibody Western Blot Protocol
Product Datasheet Link: ESR1 antibody (ARP31088_P050)
WB Suggested Anti-ESR1 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:12500
Positive Control: ACHN
Western Blot image:
Description of Target: ESR1 is an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative splicing results in several transcript variants, which differ in their 5' UTRs and use different promoters.
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