- Description of Target:
- The polycomb group (PcG) protein HPC2, which functions as a transcriptional suppressor, is a candidate of KyoT2-binding proteins. Pc2 dramatically enhances CtBP sumoylation. Pc2 is a SUMO E3, and Polycomb Group bodies may be sumoylation centers.
- Gene Symbol:
- Official Gene Full Name:
- Chromobox homolog 4
- NCBI Gene Id:
- Alias Symbols:
- PC2; NBP16
- Sample Type Confirmation:
CBX4 is supported by BioGPS gene expression data to be expressed in Jurkat
- Tissue Tool:
- Find tissues and cell lines supported by DNA array analysis to express CBX4.
- RNA Seq:
- Find tissues and cell lines supported by RNA-seq analysis to express CBX4.
- Swissprot Id:
- Protein Accession #:
- Nucleotide Accession #:
- Protein Name:
- E3 SUMO-protein ligase CBX4
- Protein Size (# AA):
- Molecular Weight:
- IHC, WB
- Protein Interactions:
- Rnf111; SUMO1; NEDD8; CBS; BMI1; EED; RNF2; HECW2; SOX2; YWHAE; YWHAB; CCDC158; DIS3L2; HIST4H4; CBX2; PARP12; RNF213; ZKSCAN7; DCAF6; KDM3A; MYCBP2; ANKRD26; PSME3; TRANK1; CBX4; HIST1H2AB; YWHAZ; SKIL; NPM1; HIST1H2BB; GTF2I; PHC2; CSNK2B; CSNK2A2; CSNK
- The immunogen is a synthetic peptide directed towards the N terminal region of human CBX4
- Product Format:
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
- Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
- Affinity Purified
- Complete computational species homology data:
- Anti-CBX4 (ARP30002_P050)
- Predicted Homology Based on Immunogen Sequence:
- Dog: 100%; Pig: 100%; Rat: 100%; Human: 100%; Mouse: 100%; Bovine: 100%; Rabbit: 100%; Guinea pig: 100%; Zebrafish: 77%
- Species Reactivity:
- Bovine, Dog, Pig, Rabbit, Rat, Guinea pig, Human, Mouse, Zebrafish
- Datasheets / Downloads:
- Printable datasheet for anti-CBX4 (ARP30002_P050) antibody
- Peptide Sequence:
- Synthetic peptide located within the following region: LLIAFQNRERQEQLMGYRKRGPKPKPLVVQVPTFARRSNVLTGLQDSSTD
- Blocking Peptide:
- For anti-CBX4 (ARP30002_P050) antibody is Catalog # AAP30002 (Previous Catalog # AAPH00102)
- Target Reference:
- Kagey,M.H., et al., (2003) Cell 113 (1), 127-137
- Reconstitution and Storage:
- For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Hao, L., Midic, U., Garriga, J. & Latham, K. E. Contribution of CBX4 to cumulus oophorus cell phenotype in mice and attendant effects in cumulus cell cloned embryos. Physiol. Genomics 46, 66-80 (2014). WB, Bovine, Dog, Pig, Rabbit, Rat, Guinea pig, Human, Mouse, Zebrafish 24280258
Aviva Systems Biology is the original manufacturer of this CBX4 antibody (ARP30002_P050)
Click here to view the CBX4 antibody Western Blot Protocol
Product Datasheet Link: CBX4 antibody (ARP30002_P050)
WB Suggested Anti-CBX4 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:1562500
Positive Control: Jurkat
Western Blot image:
Description of Target: The polycomb group (PcG) protein HPC2, which functions as a transcriptional suppressor, is a candidate of KyoT2-binding proteins. Pc2 dramatically enhances CtBP sumoylation. Pc2 is a SUMO E3, and Polycomb Group bodies may be sumoylation centers.
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Aviva Systems Biology’s CBX4 antibody (ARP30002_P050) has been tested using other cell lysates and tissues. To obtain more data about this antibody please email us at firstname.lastname@example.org.
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Aviva Systems Biology is the original manufacturer of this CBX4 antibody.
Click here to view the CBX4 antibody Immunohistochemistry (IHC) protocol
Product Datasheet Link: CBX4 antibody (ARP30002)
Rabbit Anti-CBX 4 Antibody
Catalog Number: ARP30002
Paraffin Embedded Tissue: Human Kidney
Cellular Data: Epithelial cells of renal tubule
Antibody Concentration: 4.0-8.0 ug/ml