UGT1A6 Antibody (AMM10370A)

Catalog#: AMM10370A

• Size: 100ug

Human HepG2

• Description of Target: This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene is active on phenolic and planar compounds. Alternative splicing in the unique 5' end of this gene results in two transcript variants.
• Gene Symbol: UGT1A6
• Alias Symbols: GNT1; UGT1; HLUGP; UDPGT; UGT1F; HLUGP1; UGT1A6S; UDPGT 1-6
• Protein Accession#: NP_995584
• Nucleotide Accession#: NM_001072
• Swissprot Id: Q5DT01
• Host: Mouse
• Protein Size (# AA): 534
• Molecular Weight: 58kDa
• Application: WB
• Clone: 8C6
• Product Format: Lyophilized powder
• Isotype: Mouse IgM, k
• Reconstitution and Storage: Add 100ul of distilled water. Final anti-UGT1A6 antibody concentration is 1 mg/ml in PBS buffer. For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
• Key Reference: N/A