STAT6 Antibody (AMM00020)

Catalog#: AMM00020

• Size: 100ug

Human ACHN

• Description of Target: STAT6 is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins.
• Gene Symbol: STAT6
• Alias Symbols: STAT6B; STAT6C; D12S1644; IL-4-STAT
• Protein Accession#: NP_003144
• Nucleotide Accession#: NM_003153
• Swissprot Id: P42226
• Host: Mouse
• Protein Size (# AA): 847
• Molecular Weight: 94kDa
• Application: WB
• Product Format: Lyophilized powder
• Isotype: Mouse IgG
• Reconstitution and Storage: Add 100ul of distilled water. Final anti-STAT6 antibody concentration is 1 mg/ml in PBS buffer. For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
• Key Reference: Takeda, K., et al., Nature. 380 (6575), 627-630 (1996)