Catalog No: OPCD06403
Price: $0.00
SKU
OPCD06403
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Datasheets/Manuals | Printable datasheet for PRKAG1 Recombinant Protein (OPCD06403) |
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Predicted Species Reactivity | Homo sapiens|Human |
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Product Format | Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose. |
Conjugation | Unconjugated |
Application | Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot |
Additional Information | Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method) Isoelectric Point: 8.7 |
:: | Residues: Arg70-Leu300 |
:: | Subcellular Location: Cytoplasm |
Reconstitution and Storage | 2°C to 8°C|-80°C |
Concentration | 200 ug/mL (prior to lyoph) |
Purity | > 95% |
Source | E.coli |
Tag | N-terminal His Tag |
Gene Symbol | PRKAG1 |
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Gene Full Name | protein kinase AMP-activated non-catalytic subunit gamma 1 |
Alias Symbols | 5'-AMP-activated protein kinase subunit gamma-1;5'-AMP-activated protein kinase, gamma-1 subunit;AMPK gamma1;AMPK gamma-1 chain;AMPKG;protein kinase, AMP-activated, gamma 1 non-catalytic subunit. |
NCBI Gene Id | 5571 |
Protein Name | 5'-AMP-activated protein kinase subunit gamma-1 |
Description of Target | AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit. ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive. |
Uniprot ID | P54619 |
Protein Accession # | NP_001193638.1 |
Nucleotide Accession # | NM_001206709.1 |
Protein Size (# AA) | Arg70~Leu300 |
Molecular Weight | 30kDa |
- Protocol:
- Reconstitution & Storage Instructions
- Western Blotting/Immunoblotting (WB/IB) Protocol
- Immunohistochemistry (IHC) Protocol
- Immunocytochemistry (ICC) Protocol
- Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
- Blocking Peptide Competition Protocol (BPCP)
- Immunoprecipitation (IP) Protocol
- Antibody Array (AA) Protocol
- Tips Information:
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