PRKAG1 Antibody (OABF01895)

Catalog No: OABF01895

Size:100UL

Lane 1: mouse embryo lysates Lane 2: mouse brain lysates probed with Anti PRKAG2/AMPKγ2 Polyclonal Antibody, Unconjugated (OABF01895) at 1:200 in 4C. Followed by conjugation to secondary antibody at 1:3000 90min in 37C. Predicted band 63kD. Observed band size: 63kD.

Formalin-fixed and paraffin embedded rat brain labeled with Rabbit Anti PRKAG2/AMPKγ2 Polyclonal Antibody, Unconjugated (OABF01895) at 1:200 followed by conjugation to the secondary antibody and DAB staining

Product Info

• Predicted Species Reactivity: Human|Mouse|Other|Rat
• Product Format: Liquid. Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide.
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Conjugation: Unconjugated
• Application: Immunofluorescence|Immunohistochemistry-Paraffin|Western blot
• Additional Information: Subcellular location: Extracellular, Cytoplasm, Nucleus
• Reconstitution and Storage: -20°C
• Immunogen: KLH conjugated synthetic peptide derived from human PRKAG2/AMPK_2
• Purification: Protein A Purified
• Concentration: 1 ug/ul
• Application Info: WB: 1:100 - 1000
  IHC-P: : 1:100 - 500

Target Info

• Gene Symbol: PRKAG1|PRKAG2|PRKAG3
• Gene Full Name: protein kinase AMP-activated non-catalytic subunit gamma 1|protein kinase AMP-activated non-catalytic subunit gamma 2|protein kinase AMP-activated non-catalytic subunit gamma 3
• Alias Symbols: 5'-AMP-activated protein kinase subunit gamma-1;5'-AMP-activated protein kinase subunit gamma-2;5'-AMP-activated protein kinase subunit gamma-3;5'-AMP-activated protein kinase, gamma-1 subunit;5'-AMP-activated protein kinase, gamma-3 subunit;AAKG;AAKG2;AMPK gamma1;AMPK gamma-1 chain;AMPK gamma3;AMPK gamma-3 chain;AMPK subunit gamma-2;AMPK subunit gamma-3;AMPKG;AMPKG3;CMH6;epididymis secretory sperm binding protein;H91620p;protein kinase, AMP-activated, gamma 1 non-catalytic subunit;protein kinase, AMP-activated, gamma 2 non-catalytic subunit;protein kinase, AMP-activated, gamma 3 non-catalytic subunit;SMGMQTL;WPWS.
• NCBI Gene Id: 51422|53632|5571
• Description of Target: AMPK is a heterotrimeric complex comprising a catalytic a subunit and regulatory b and g subunits. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. AMPK is activated by high AMP and low ATP through a mechanism involving allosteric regulation, promotion of phosphorylation by an upstream protein kinase known as AMPK kinase and inhibition of dephosphorylation. Activated AMPK can phosphorylate and regulate in vivo hydroxy-methylglutaryl-CoA reductase and acetyl-CoA carboxylase, which are key regulatory enzymes of sterol synthesis and fatty acid synthesis, respectively. The human AMPKa1 and AMPKa2 genes encode 548 amino acid and 552 amino acid proteins, respectively. Human AMPKb1 encodes a 271 amino acid protein and human AMPKb2 encodes a 272 amino acid protein. The human AMPKg1 gene encodes a 331 amino acid protein. Human AMPKg2 and AMPKg3, which are 569 and 492 amino acid proteins, respectively, contain unique N-terminal domains and may participate directly in the binding of AMP within the AMPK complex.