PPIB Antibody - C-terminal region (ARP44366_T100)

Catalog No: ARP44366_T100

WB Suggested Anti-PPIB Antibody Titration: 1.25ug/ml
Positive Control: HepG2 cell lysate

Human Liver

Product Info

• Tested Species Reactivity: Human
• Predicted Species Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Clonality: Polyclonal
• Host: Rabbit
• Application: IHC, WB
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human PPIB
• Purification: Protein A purified
• Predicted Homology Based on Immunogen Sequence: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 86%
• Peptide Sequence: Synthetic peptide located within the following region: VVFGKVLEGMEVVRKVESTKTDSRDKPLKDVIIADCGKIEVEKPFAIAKE
• Concentration: 1.0 mg/ml
• Blocking Peptide: For anti-PPIB (ARP44366_T100) antibody is Catalog # AAP44366 (Previous Catalog # AAPS14902)
• Reference: Watashi,K., (2005) Mol. Cell 19 (1), 111-122

Target Info

• Gene Symbol: PPIB
• Gene Full Name: Peptidylprolyl isomerase B (cyclophilin B)
• Alias Symbols: B, OI9, CYPB, SCYLP, CYP-S1, HEL-S-39
• NCBI Gene Id: 5479
• Protein Name: Peptidyl-prolyl cis-trans isomerase B
• Description of Target: PPIB is a cyclosporine-binding protein and is mainly located within the endoplasmic reticulum. It is associated with the secretory pathway and released in biological fluids. This protein can bind to cells derived from T- and B-lymphocytes, and may regulate cyclosporine A-mediated immunosuppression. Western blots using two different antibodies against two unique regions of this protein target confirm the same apparent molecular weight in our tests.The protein encoded by this gene is a cyclosporine-binding protein and is mainly located within the endoplasmic reticulum. It is associated with the secretory pathway and released in biological fluids. This protein can bind to cells derived from T- and B-lymphocytes, and may regulate cyclosporine A-mediated immunosuppression.
• Uniprot ID: A8K534
• Protein Accession #: NP_000933
• Nucleotide Accession #: NM_000942
• Protein Size (# AA): 216
• Molecular Weight: 24kDa
• Protein Interactions: BANP; UBQLN1; SGTA; PEX19; UBC; MDM2; DDIT3; WWOX; SUZ12; EED; BMI1; rev; RRM1; PPP5C; PFKP; GAPDH; HECW2; FBXO6; UBD; CFTR; ATP12A; VKORC1; OS9; MAGT1; SUGP1; LSM4; TIMM44; SCO2; ZC3H11A; UBL4A; RBMS1; RANGAP1; PCBP2; P4HB; HSPA5; PDIA3; DHX9; ACAA1; MRP