P4HB Protein (AEP10025)

Catalog No: AEP10025

Size:100ug

Gel Concentration: 12%

Product Info

• Tested Species Reactivity: Human
• Predicted Species Reactivity: Human
• Product Format: Lyophilized powder
• Application: WB
• Reconstitution and Storage: Reconstitute with distilled water. For longer periods of storage, store at -20C. Avoid repeat freeze and thaw cycles.
• Protein Sequence: MLRRALLCLAVAALVRADAPEEEDHVLVLRKSNFAEALAAHKYLLVEFYAPWCGHCKALAPEYAKAAGKLKAEGSEIRLAKVDATEESDLAQQYGVRGYPTIKFFRNGDTASPKEYTAGREADDIVNWLKKRTGPAATTLPDGAAAESLVESSEVAVIGFFKDVESDSAKQFLQAAEAIDDIPFGITSNSDVFSKYQLDKDGVVLFKKFDEGRNNFEGEVTKENLLDFIKHNQLPLVIEFTEQTAPKIFGGEIKTHILLFLPKSVSDYDGKLSNFKTAAESFKGKILFIFIDSDHTDNQRILEFFGLKKEECPAVRLITLEEEMTKYKPESEELTAERITEFCHRFLEGKIKPHLMSQELPEDWDKQPVKVLVGKNFEDVAFDEKKNVFVEFYAPWCGHCKQLAPIWDKLGETYKDHENIVIAKMDSTANEVEAVKVHSFPTLKFFPASADRTVIDYNGERTLDGFKKFLESGGQDGAGDDDDLEDLEEAEEPDMEEDDDQKAVKDEL
• Tag: GST in N-terminal
• Quality Control: This product was tested on western blot.
  Application : Western blot standard.
  Observed Molecular Weight: 85
  Protein Purity : 90%
  Expression system : Bacteria

Target Info

• Gene Symbol: P4HB
• Alias Symbols: DSI, GIT, PDI, PHDB, PDIA1, PO4DB, PO4HB, PROHB, CLCRP1, ERBA2L, P4Hbeta
• NCBI Gene Id: 5034
• Protein Name: Protein disulfide-isomerase
• Description of Target: P4HB is the beta subunit of prolyl 4-hydroxylase, a highly abundant multifunctional enzyme that belongs to the protein disulfide isomerase family. When present as a tetramer consisting of two alpha and two beta subunits, this enzyme is involved in hydroxylation of prolyl residues in preprocollagen. This enzyme is also a disulfide isomerase containing two thioredoxin domains that catalyze the formation, breakage and rearrangement of disulfide bonds. Other known functions include its ability to act as a chaperone that inhibits aggregation of misfolded proteins in a concentration-dependent manner, its ability to bind thyroid hormone, its role in both the influx and efflux of S-nitrosothiol-bound nitric oxide, and its function as a subunit of the microsomal triglyceride transfer protein complex.
• Uniprot ID: P07237
• Protein Accession #: NP_000909
• Nucleotide Accession #: NM_000918
• Molecular Weight: 85
• Protein Interactions: P4HB; UBC; AGO2; MDM2; SUZ12; RNF2; EZH2; BMI1; rev; ACAA2; PLIN3; UBA2; USP5; TPD52L2; PSMD9; PFDN2; CLNS1A; TCEAL4; P3H1; UBQLN2; PABPC1; CALU; PARK2; HNRNPD; EGFR; UBD; BAG3; CXCR4; env; UBL4A; CSNK2A2; ATF2; GRDX; TMED9; GANAB; CCT4; CCT7; PDIA6; PDIA