Catalog No: P102230_P050
Price: $0.00
SKU
P102230_P050
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Datasheets/ManualsPrintable datasheet for anti-NUCB1 (P102230_P050) antibody
Product Info
Tested Species ReactivityHuman
Predicted Species ReactivityHuman
Product FormatLiquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
ClonalityPolyclonal
HostRabbit
ApplicationWB
Reconstitution and StorageFor short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
ImmunogenThe immunogen is a synthetic peptide directed towards the C terminal region of human NUCB1
PurificationAffinity Purified
Predicted Homology Based on Immunogen SequenceHuman: 100%
Peptide SequenceSynthetic peptide located within the following region: PAAHPEGQLKFHPDTDDVPVPAPAGDQKEVDTSEKKLLERLPEVEVPQHL
Concentration0.5 mg/ml
Blocking PeptideFor anti-NUCB1 (P102230_P050) antibody is Catalog # AAP32192
Referencede Alba,E. et al., (2004) Biochemistry 43 (31), 10039-10049
Publications

Larkin, H., Ribeiro, M. G. & Lavoie, C. Topology and Membrane Anchoring of the Lysosomal Storage Disease-Related Protein CLN5. Hum. Mutat. 34, 1688-97 (2013). 24038957

Lin, P., Fischer, T., Lavoie, C., Huang, H. & Farquhar, M. G. Calnuc plays a role in dynamic distribution of Galphai but not Gbeta subunits and modulates ACTH secretion in AtT-20 neuroendocrine secretory cells. Mol. Neurodegener. 4, 15 (2009). 19320978

Nucleobindin 1 binds to multiple types of pre-fibrillar amyloid and inhibits fibrillization. Sci Rep. 7, 42880 (2017). 28220836

Sugeno, N. et al. Serine 129 phosphorylation of alpha-synuclein induces unfolded protein response-mediated cell death. J. Biol. Chem. 283, 23179-88 (2008). 18562315

Valencia, C. A., Cotten, S. W., Duan, J. & Liu, R. Modulation of nucleobindin-1 and nucleobindin-2 by caspases. FEBS Lett. 582, 286-90 (2008). 18154733

Description
Gene SymbolNUCB1
Gene Full NameNucleobindin 1
Alias SymbolsNUC, CALNUC
NCBI Gene Id4924
Protein NameNucleobindin-1
Description of TargetNucleobindin, also known as calnuc, participates in Ca2+ storage in the Golgi, as well as in other biological processes that involve DNA-binding and protein-protein interactions.
Uniprot IDQ02818
Protein Accession #NP_006175
Nucleotide Accession #NM_006184
Protein Size (# AA)461
Molecular Weight54kDa
Protein InteractionsREL; UBC; MDM2; CTPS2; RAD23B; PRKDC; METTL1; GTF2I; CBS; XPNPEP1; WARS; PTGS2; XPO1; SET; RBL1; MYC; HIVEP1; GNAS; GNAI3; GNAI1; KLC4; PTGS1; NDN; GNAI2; GNAO1; GNAZ;
  1. What is the species homology for "NUCB1 Antibody - C-terminal region (P102230_P050)"?

    The tested species reactivity for this item is "Human". This antibody is predicted to have homology to "Human".

  2. How long will it take to receive "NUCB1 Antibody - C-terminal region (P102230_P050)"?

    This item is available "Domestic: within 1-2 days delivery | International: 1-2 days".

  3. What buffer format is "NUCB1 Antibody - C-terminal region (P102230_P050)" provided in?

    This item is provided in "Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "NUCB1 Antibody - C-terminal region (P102230_P050)"?

    This target may also be called "NUC, CALNUC" in publications.

  5. What is the shipping cost for "NUCB1 Antibody - C-terminal region (P102230_P050)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "NUCB1 Antibody - C-terminal region (P102230_P050)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "NUCB1 Antibody - C-terminal region (P102230_P050)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "54kDa".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "NUCB1 Antibody - C-terminal region (P102230_P050)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "NUCB1"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "NUCB1"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "NUCB1"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "NUCB1"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "NUCB1"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "NUCB1"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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