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Datasheets/Manuals | Printable datasheet for anti-NR4A2 (ARP38753_P050) antibody |
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Tested Species Reactivity | Human, Mouse |
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Predicted Species Reactivity | Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish |
Product Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Clonality | Polyclonal |
Host | Rabbit |
Application | IHC, WB |
Additional Information | IHC Information: Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE) IHC Information: Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE) |
Reconstitution and Storage | For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
Immunogen | The immunogen is a synthetic peptide directed towards the N terminal region of human NR4A2 |
Purification | Affinity Purified |
Predicted Homology Based on Immunogen Sequence | Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100% |
Peptide Sequence | Synthetic peptide located within the following region: MPCVQAQYGSSPQGASPASQSYSYHSSGEYSSDFLTPEFVKFSMDLTNTE |
Concentration | 0.5 mg/ml |
Blocking Peptide | For anti-NR4A2 (ARP38753_P050) antibody is Catalog # AAP38753 (Previous Catalog # AAPS04510) |
Reference | Smith,A.G., (2008) J. Biol. Chem. 283 (18), 12564-12570 |
Publications | Epigenetic Reprogramming of Cortical Neurons through Alteration of Dopaminergic Circuits. Mol Psychiatry. 19, 1193-1200 (2014). 25023144 |
Gene Symbol | NR4A2 |
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Gene Full Name | Nuclear receptor subfamily 4, group A, member 2 |
Alias Symbols | NOT, RNR1, HZF-3, NURR1, TINUR |
NCBI Gene Id | 4929 |
Protein Name | Nuclear receptor subfamily 4 group A member 2 |
Description of Target | NR4A2 is a member of the steroid-thyroid hormone-retinoid receptor superfamily. The protein may act as a transcription factor. Mutations in NR4A2 gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson disease, schizophernia, and manic depression. Misregulation of NR4A2 gene may be associated with rheumatoid arthritis.This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcription factor. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson disease, schizophernia, and manic depression. Misregulation of this gene may be associated with rheumatoid arthritis. Four transcript variants encoding four distinct isoforms have been identified for this gene. Additional alternate splice variants may exist, but their full length nature has not been determined.This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcription factor. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson disease, schizophernia, and manic depression. Misregulation of this gene may be associated with rheumatoid arthritis. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. |
Uniprot ID | P43354 |
Protein Accession # | NP_006177 |
Nucleotide Accession # | NM_006186 |
Protein Size (# AA) | 598 |
Molecular Weight | 66kDa |
Protein Interactions | CDKN2D; TCEAL5; BAZ1B; ELAVL1; COPS5; RXRB; RXRA; RUNX1; SMARCA4; SMARCA2; SIN3A; NCOR2; SFPQ; PIAS4; RPS6KA1; CDKN1C; RARB; RARA; CREB1; |
- Protocol:
- Reconstitution & Storage Instructions
- Western Blotting/Immunoblotting (WB/IB) Protocol
- Immunohistochemistry (IHC) Protocol
- Immunocytochemistry (ICC) Protocol
- Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
- Blocking Peptide Competition Protocol (BPCP)
- Immunoprecipitation (IP) Protocol
- Antibody Array (AA) Protocol
- Tips Information:
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See our General FAQ page.
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What is the species homology for "NR4A2 Antibody - N-terminal region (ARP38753_P050)"?
The tested species reactivity for this item is "Human, Mouse". This antibody is predicted to have homology to "Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish".
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How long will it take to receive "NR4A2 Antibody - N-terminal region (ARP38753_P050)"?
This item is available "Domestic: within 1-2 days delivery | International: 1-2 days".
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What buffer format is "NR4A2 Antibody - N-terminal region (ARP38753_P050)" provided in?
This item is provided in "Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.".
Additional format options may be available. For more information please contact info@avivasysbio.com. -
What are other names for "NR4A2 Antibody - N-terminal region (ARP38753_P050)"?
This target may also be called "NOT, RNR1, HZF-3, NURR1, TINUR" in publications.
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What is the shipping cost for "NR4A2 Antibody - N-terminal region (ARP38753_P050)"?
The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.
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What is the guarantee for "NR4A2 Antibody - N-terminal region (ARP38753_P050)"?
All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.
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Can I get bulk pricing for "NR4A2 Antibody - N-terminal region (ARP38753_P050)"?
You can get bulk pricing for this item by going here.
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What is the molecular weight of the protein?
The molecular weight reported by Uniprot for this item is "66kDa".
Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics. -
What protocols are available for "NR4A2 Antibody - N-terminal region (ARP38753_P050)"?
We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.
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What are positive controls for "NR4A2"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What are negative controls for "NR4A2"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What other proteins interact with "NR4A2"?
This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.
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What biological processes are associated with "NR4A2"?
This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.
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What cellular components are associated with "NR4A2"?
This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.
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What protein functions are associated with "NR4A2"?
This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.