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Catalog No: ARP45626_P050
Price: $0.00
SKU
ARP45626_P050
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Datasheets/ManualsPrintable datasheet for anti-NR1H4 (ARP45626_P050) antibody
Product Info
Tested Species ReactivityHuman
Predicted Species ReactivityHuman, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit
Product FormatLiquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
ClonalityPolyclonal
HostRabbit
ApplicationWB
Reconstitution and StorageFor short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
ImmunogenThe immunogen is a synthetic peptide directed towards the middle region of human NR1H4
PurificationAffinity Purified
Predicted Homology Based on Immunogen SequenceCow: 93%; Dog: 93%; Guinea Pig: 86%; Horse: 93%; Human: 100%; Mouse: 93%; Pig: 93%; Rabbit: 93%; Rat: 93%
Peptide SequenceSynthetic peptide located within the following region: SAVEAMFLRSAEIFNKKLPSGHSDLLEERIRNSGISDEYITPMFSFYKSI
Concentration0.5 mg/ml
Blocking PeptideFor anti-NR1H4 (ARP45626_P050) antibody is Catalog # AAP45626 (Previous Catalog # AAPP11909)
ReferenceKaeding,J., (2008) Biochem. J. 410 (2), 245-253
Publications

Yamada, T. et al. Guggulsterone suppresses bile acid-induced and constitutive caudal-related homeobox 2 expression in gut-derived adenocarcinoma cells. Anticancer Res. 30, 1953-60 (2010). 20651339

Gene SymbolNR1H4
Gene Full NameNuclear receptor subfamily 1, group H, member 4
Alias SymbolsBAR, FXR, HRR1, HRR-1, PFIC5, RIP14
NCBI Gene Id9971
Protein NameFarnesoid X receptor EMBL BAH02290.1
Description of TargetNR1H4 is the receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. NR1H4 represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two d
Uniprot IDB6ZGS9
Protein Accession #NP_005114
Nucleotide Accession #NM_005123
Protein Size (# AA)472
Molecular Weight56 kDa
Protein InteractionsSMARCD3; HDAC6; SUMO1; NCOR2; ESR1; RRM2; GPS2; RXRG; GAPDH; RXRA; EP300; SIRT1; SRC; NCOA6; CARM1; HIST1H4A; HIST1H3A; PRMT1; NCOR1; XRCC5; PRKDC; XRCC6; NCOA1; CASP8; SMARCD1;
  1. What is the species homology for "NR1H4 Antibody - middle region (ARP45626_P050)"?

    The tested species reactivity for this item is "Human". This antibody is predicted to have homology to "Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit".

  2. How long will it take to receive "NR1H4 Antibody - middle region (ARP45626_P050)"?

    This item is available "Domestic: within 1-2 days delivery | International: 1-2 days".

  3. What buffer format is "NR1H4 Antibody - middle region (ARP45626_P050)" provided in?

    This item is provided in "Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "NR1H4 Antibody - middle region (ARP45626_P050)"?

    This target may also be called "BAR, FXR, HRR1, HRR-1, PFIC5, RIP14" in publications.

  5. What is the shipping cost for "NR1H4 Antibody - middle region (ARP45626_P050)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "NR1H4 Antibody - middle region (ARP45626_P050)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "NR1H4 Antibody - middle region (ARP45626_P050)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "56 kDa".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "NR1H4 Antibody - middle region (ARP45626_P050)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "NR1H4"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "NR1H4"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "NR1H4"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "NR1H4"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "NR1H4"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "NR1H4"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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