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Catalog No: OAAB16399
Size:400ul
Price: $450.00
SKU
OAAB16399
Availability: Domestic: within 1-2 week delivery | International: within 1-2 week delivery
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  • $55: Antibody & Protein in US
  • $55 + $25/Kit in US
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Datasheets/ManualsPrintable datasheet for OAAB16399
Product Info
Predicted Species ReactivityMouse
Product FormatPurified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
ClonalityPolyclonal
IsotypeIg
HostRabbit
ApplicationDB
Additional InformationPrecautions: mouse ERBB2 (Phospho S1114) is for research use only and not for use in diagnostic or therapeutic procedures.
::Function: Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization (By similarity)
::Cellular Location: Cell membrane; Single-pass type I membrane protein (By similarity). Cytoplasm, perinuclear region (By similarity). Nucleus (By similarity)
Tissue Location: Expressed predominantly in uterine epithelial cells. In the muscle, expression localizes to the synaptic sites of muscle fibers
Reconstitution and StorageMaintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
ImmunogenThis mouse ERBB2 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S1114 of mouse ERBB2.
Predicted Homology Based on Immunogen SequenceMouse
ConcentrationApproximately 0.5mg/ml. Actual concentration varies with each lot.
Application InfoDB: 1:500
Gene SymbolErbb2
Alias SymbolsNe, HER, Neu, HER-, HER2, c-ne, ErbB-, HER-2, c-neu, l11Ju, Erbb-2, c-erbB, c-erbB2, l11Jus8, mKIAA3023
NCBI Gene Id13866
Protein NameReceptor tyrosine-protein kinase erbB-2
Description of TargetPeptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Uniprot IDP70424
Protein Accession #NP_001003817.1
Molecular Weight138579 Da
  1. What is the species homology for "ERBB2 Antibody (Phospho-Ser1114) (OAAB16399)"?

    The tested species reactivity for this item is "". This antibody is predicted to have homology to "Mouse".

  2. How long will it take to receive "ERBB2 Antibody (Phospho-Ser1114) (OAAB16399)"?

    This item is available "Domestic: within 1-2 week delivery | International: within 1-2 week delivery".

  3. What buffer format is "ERBB2 Antibody (Phospho-Ser1114) (OAAB16399)" provided in?

    This item is provided in "Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "ERBB2 Antibody (Phospho-Ser1114) (OAAB16399)"?

    This target may also be called "Ne, HER, Neu, HER-, HER2, c-ne, ErbB-, HER-2, c-neu, l11Ju, Erbb-2, c-erbB, c-erbB2, l11Jus8, mKIAA3023" in publications.

  5. What is the shipping cost for "ERBB2 Antibody (Phospho-Ser1114) (OAAB16399)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "ERBB2 Antibody (Phospho-Ser1114) (OAAB16399)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "ERBB2 Antibody (Phospho-Ser1114) (OAAB16399)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "138579 Da".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "ERBB2 Antibody (Phospho-Ser1114) (OAAB16399)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "ERBB2"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "ERBB2"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "ERBB2"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "ERBB2"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "ERBB2"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "ERBB2"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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