MARCH4 Antibody (OAAF03612)

Catalog No: OAAF03612 (Formerly GWB-ASE558)

Size:100 ug

Immunohistochemistry analysis of paraffin-embedded human brain tissue, using MARCH4 Antibody. The picture on the right is treated with the synthesized peptide.

Product Info

• Predicted Species Reactivity: Human|Mouse
• Product Format: Liquid
• Clonality: Polyclonal
• Host: Rabbit
• Application: Enzyme-linked immunosorbent assay|Immunofluorescence|Immunohistochemistry|Immunohistochemistry-Paraffin
• Reconstitution and Storage: -20°C
• Immunogen: The antiserum was produced against synthesized peptide derived from human MARCH4.
• Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Specificity: MARCH4 antibody detects endogenous levels of total MARCH4 protein.
• Formulation: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Dilution: The optimal working dilution should be determined by the end user.
• Application Info: IHC: 1:50~1:100; ELISA: 1:40000
• Reference: Nagase T., DNA Res. 7:65-73(2000).
  The MGC Project Team; Genome Res. 14:2121-2127(2004).
  Bartee E., J. Virol. 78:1109-1120(2004).

Target Info

• Gene Symbol: MARCHF4
• Gene Full Name: membrane associated ring-CH-type finger 4
• Alias Symbols: E3 ubiquitin-protein ligase MARCH4;E3 ubiquitin-protein ligase MARCHF4;MARCH4;MARCH-IV;membrane associated ring finger 4;membrane-associated ring finger (C3HC4) 4, E3 ubiquitin protein ligase;membrane-associated RING finger protein 4;membrane-associated RING-CH protein IV;RING finger protein 174;RING-type E3 ubiquitin transferase MARCH4;RING-type E3 ubiquitin transferase MARCHF4;RNF174.
• NCBI Gene Id: 57574
• Protein Name: E3 ubiquitin-protein ligase MARCH4
• Description of Target: E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I and CD4, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.
• Uniprot ID: Q9P2E8
• Protein Accession #: NP_065865.1
• Molecular Weight: 45 kDa