MAP3K8 Antibody (OASG01775)

Catalog No: OASG01775

Size:100 uL

Western Blot using 293

Product Info

• Predicted Species Reactivity: Human, Mouse, Rat
• Product Format: Liquid. 1 mg/mL in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Application: WB, IHC, IF
• Reconstitution and Storage: Store at -20C. Avoid repeated freeze/thaw cycles.
• Immunogen: Synthesized peptide derived from human Cot around the non-phosphorylation site of T290. Location: 230-310aa.
• Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Concentration: 1 mg/ml
• Specificity: COT Polyclonal Antibody detects endogenous levels of COT protein.
• Application Info: WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:40000;

Target Info

• Gene Symbol: MAP3K8
• Gene Full Name: mitogen-activated protein kinase kinase kinase 8
• Alias Symbols: COT, EST, ESTF, TPL2, AURA2, MEKK8, Tpl-2, c-COT
• NCBI Gene Id: 1326; 26410; 116596
• Description of Target: This gene is an oncogene that encodes a member of the serine/threonine protein kinase family. The encoded protein localizes to the cytoplasm and can activate both the MAP kinase and JNK kinase pathways. This protein was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This protein was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. This gene may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity. Alternate splicing results in multiple transcript variants that encode the same protein.
• Uniprot ID: P41279, Q07174, Q63562
• Molecular Weight: 60 kDa