MAP2K2 Antibody - N-terminal region (ARP48941_P050)

Catalog No: ARP48941_P050

WB Suggested Anti-MAP2K2 Antibody Titration: 1 ug/ml
Positive Control: HepG2 cell lysateThere is BioGPS gene expression data showing that MAP2K2 is expressed in HepG2

Product Info

• Tested Species Reactivity: Human
• Predicted Species Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Clonality: Polyclonal
• Host: Rabbit
• Application: WB, IHC
• Additional Information: IHC Information: Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE)
  IHC Information: Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE)
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human MAP2K2
• Purification: Affinity Purified
• Predicted Homology Based on Immunogen Sequence: Cow: 93%; Dog: 93%; Guinea Pig: 93%; Human: 100%; Mouse: 100%; Rat: 100%
• Peptide Sequence: Synthetic peptide located within the following region: LARRKPVLPALTINPTIAEGPSPTSEGASEANLVDLQKKLEELELDEQQK
• Concentration: 0.5 mg/ml
• Blocking Peptide: For anti-MAP2K2 (ARP48941_P050) antibody is Catalog # AAP48941 (Previous Catalog # AAPY02619)
• Sample Type Confirmation:

  There is BioGPS gene expression data showing that MAP2K2 is expressed in HepG2

• Reference: Adjei,A.A., (2008) J. Clin. Oncol. 26 (13), 2139-2146

Target Info

• Gene Symbol: MAP2K2
• Gene Full Name: Mitogen-activated protein kinase kinase 2
• Alias Symbols: CFC4, MEK2, MKK2, MAPKK2, PRKMK2
• NCBI Gene Id: 5605
• Protein Name: Dual specificity mitogen-activated protein kinase kinase 2
• Description of Target: MAP2K2 is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in MAP2K2 gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene.The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
• Uniprot ID: P36507
• Protein Accession #: NP_109587
• Nucleotide Accession #: NM_030662
• Protein Size (# AA): 400
• Molecular Weight: 44kDa
• Protein Interactions: CCNDBP1; RAF1; SUMO2; UBC; EGFR; IQGAP1; NFE2L2; YWHAB; MAPK1; PEX14; BRAF; ARAF; FAM65B; ZNF207; LIG4; MAPK8; WDR83; Ksr1; COPS5; MAP2K1; MEPCE; GRIN1; CNKSR1; LAMTOR3; GRIN2D; RGS12; CASP9; MAPK3; MAP2K2; DUSP3; Flna;