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Datasheets/Manuals | Printable datasheet for MAFB Antibody (C-term) (OAAB08482) |
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Predicted Species Reactivity | Human, Mouse, Primate, Rat, Xenopus |
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Product Format | Liquid.PBS with 0.09% (W/V) sodium azide. |
Clonality | Polyclonal |
Isotype | Ig |
Host | Rabbit |
Application | Flow cytometry, Western blot |
Additional Information | Function: Acts as a transcriptional activator or repressor. Plays a pivotal role in regulating lineage-specific hematopoiesis by repressing ETS1-mediated transcription of erythroid-specific genes in myeloid cells. Required for monocytic, macrophage, podocyte and islet beta cell differentiation. Involved in renal tubule survival and F4/80 maturation. Activates the insulin and glucagon promoters. Together with PAX6, transactivates weakly the glucagon gene promoter through the G1 element. SUMO modification controls its transcriptional activity and ability to specify macrophage fate. Binds element G1 on the glucagon promoter (By similarity) Involved either as an oncogene or as a tumor suppressor, depending on the cell context. Cellular Location: Nucleus Tissue Location: Ubiquitous |
Reconstitution and Storage | Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles. |
Immunogen | This MAFB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 266-292 amino acids from the C-terminal region of human MAFB. |
Purification | This antibody is purified through a protein A column, followed by peptide affinity purification. |
Predicted Homology Based on Immunogen Sequence | Human; Mouse; Rat |
Concentration | Approximately 0.5mg/ml. Actual concentration varies with each lot. |
Application Info | WB: 1:1,000 FC: 1:10~50 Optimal dilutions should be determined by the end user. |
Reference | Kim, H., et al. Nat. Immunol. 11(8):743-750(2010) Beaty, T.H., et al. Nat. Genet. 42(6):525-529(2010) Vatsveen, T.K., et al. Leuk. Res. 33(12):1670-1677(2009) Zanocco-Marani, T., et al. Exp. Cell Res. 315(11):1798-1808(2009) Kathiresan, S., et al. Nat. Genet. 41(1):56-65(2009) |
Gene Symbol | MAFB |
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Gene Full Name | MAF bZIP transcription factor B |
Alias Symbols | DURS3;Kreisler;Kreisler maf-related leucine zipper homolog;KRML;MAFB/Kreisler basic region/leucine zipper transcription factor;MCTO;Segmentation protein Kr;Transcription factor Maf-1;transcription factor MafB;v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B;V-maf musculoaponeurotic fibrosarcoma oncogene homolog B. |
NCBI Gene Id | 9935 |
Protein Name | NP_005452.2, P54841, P54842, Q2PFS4, Q6DE84, Q9Y5Q3 |
Description of Target | Transcription factor MafB, transcription factor MafB [Homo sapiens] |
Uniprot ID | https://www.uniprot.org/uniprot/?query=P54841+OR+P54842+OR+Q2PFS4+OR+Q6DE84+OR+Q9Y5Q3 |
Protein Accession # | https://www.ncbi.nlm.nih.gov/protein/NP_005452.2 |
Molecular Weight | 35792 |
- Protocol:
- Reconstitution & Storage Instructions
- Western Blotting/Immunoblotting (WB/IB) Protocol
- Immunohistochemistry (IHC) Protocol
- Immunocytochemistry (ICC) Protocol
- Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
- Blocking Peptide Competition Protocol (BPCP)
- Immunoprecipitation (IP) Protocol
- Antibody Array (AA) Protocol
- Tips Information:
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See our General FAQ page.
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What is the species homology for "MAFB Antibody - C-terminal region (OAAB08482)"?
The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human, Mouse, Primate, Rat, Xenopus".
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How long will it take to receive "MAFB Antibody - C-terminal region (OAAB08482)"?
This item is available "Domestic: within 1-2 weeks delivery | International: 1-2 weeks ".
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What buffer format is "MAFB Antibody - C-terminal region (OAAB08482)" provided in?
This item is provided in "Liquid.PBS with 0.09% (W/V) sodium azide. ".
Additional format options may be available. For more information please contact info@avivasysbio.com. -
What are other names for "MAFB Antibody - C-terminal region (OAAB08482)"?
This target may also be called "DURS3;Kreisler;Kreisler maf-related leucine zipper homolog;KRML;MAFB/Kreisler basic region/leucine zipper transcription factor;MCTO;Segmentation protein Kr;Transcription factor Maf-1;transcription factor MafB;v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B;V-maf musculoaponeurotic fibrosarcoma oncogene homolog B." in publications.
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What is the shipping cost for "MAFB Antibody - C-terminal region (OAAB08482)"?
The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.
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What is the guarantee for "MAFB Antibody - C-terminal region (OAAB08482)"?
All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.
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Can I get bulk pricing for "MAFB Antibody - C-terminal region (OAAB08482)"?
You can get bulk pricing for this item by going here.
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What is the molecular weight of the protein?
The molecular weight reported by Uniprot for this item is "35792".
Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics. -
What protocols are available for "MAFB Antibody - C-terminal region (OAAB08482)"?
We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.
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What are positive controls for "MAFB"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What are negative controls for "MAFB"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What other proteins interact with "MAFB"?
This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.
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What biological processes are associated with "MAFB"?
This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.
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What cellular components are associated with "MAFB"?
This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.
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What protein functions are associated with "MAFB"?
This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.