LONP1 Antibody (OACA09415)

Catalog No: OACA09415

Immunofluorescent analysis of HepG2 cells at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

Immunohistochemistry of paraffin-embedded human thyroid tissue at dilution of 1:100

Immunohistochemistry of paraffin-embedded human thyroid tissue at dilution of 1:100

Immunofluorescent analysis of HepG2 cells at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

Product Info

• Predicted Species Reactivity: Human
• Product Format: Liquid
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Conjugation: Unconjugated
• Application: Enzyme-linked immunosorbent assay|Immunofluorescence|Immunohistochemistry
• Reconstitution and Storage: -20°C or -80°C
• Immunogen: Recombinant Human Lon protease homolog, mitochondrial protein (614-959AA)
• Purification: Protein G Purified
• Preservative: 0.03% Proclin 300
• Formulation: 50% Glycerol, 0.01M PBS, PH 7.4
• Purity: >95%

Target Info

• Gene Symbol: LONP1
• Gene Full Name: lon peptidase 1, mitochondrial
• Alias Symbols: CODASS;hLON;hLON ATP-dependent protease;LON;lon protease homolog, mitochondrial;Lon protease-like protein;LonHS;LONP;mitochondrial ATP-dependent protease Lon;mitochondrial lon protease-like protein;PIM1;PRSS15;serine protease 15.
• NCBI Gene Id: 9361
• Protein Name: Lon protease homolog, mitochondrial
• Description of Target: ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial promoters and RNA in a single-stranded, site-specific, and strand-specific manner. May regulate mitochondrial DNA replication and/or gene expression using site-specific, single-stranded DNA binding to target the degradation of regulatory proteins binding to adjacent sites in mitochondrial promoters (PubMed:12198491, PubMed:15870080, PubMed:17420247, PubMed:8248235). Endogenous substrates include mitochondrial steroidogenic acute regulatory (StAR) protein, helicase Twinkle (TWNK) and the large ribosomal subunit protein bL32m. bL32m is protected from degradation by LONP1 when it is bound to a nucleic acid (RNA), but TWNK is not (PubMed:17579211, PubMed:28377575).
• Uniprot ID: P36776
• Protein Accession #: NP_001263408
• Nucleotide Accession #: NM_001276479