LNX1 Antibody - C-terminal region (ARP43367_T100)

Catalog No: ARP43367_T100

WB Suggested Anti-LNX1 Antibody Titration: 1.25ug/ml
Positive Control: Transfected 293T

Host: Rabbit
Target Name: LNX1
Sample Tissue: Human 786-0 Whole Cell
Antibody Dilution: 1ug/ml

Product Info

• Tested Species Reactivity: Human
• Predicted Species Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Clonality: Polyclonal
• Host: Rabbit
• Application: WB
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human LNX1
• Purification: Protein A purified
• Predicted Homology Based on Immunogen Sequence: Cow: 100%; Dog: 100%; Guinea Pig: 93%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 100%
• Peptide Sequence: Synthetic peptide located within the following region: SHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVA
• Concentration: 1.0 mg/ml
• Blocking Peptide: For anti-LNX1 (ARP43367_T100) antibody is Catalog # AAP43367 (Previous Catalog # AAPS15105)
• Reference: Weiss,A., (2007) FEBS Lett. 581 (26), 5131-5136

Target Info

• Gene Symbol: LNX1
• Gene Full Name: Ligand of numb-protein X 1, E3 ubiquitin protein ligase
• Alias Symbols: LNX, MPDZ, PDZRN2
• NCBI Gene Id: 84708
• Protein Name: E3 ubiquitin-protein ligase LNX
• Description of Target: LNX1 is a membrane-bound protein that is involved in signal transduction and protein interactions. LNX1 is an E3 ubiquitin-protein ligase, which mediates ubiquitination and subsequent proteasomal degradation of proteins containing phosphotyrosine binding (PTB) domains. This protein may play an important role in tumorogenesis.This gene encodes a membrane-bound protein that is involved in signal transduction and protein interactions. The encoded product is an E3 ubiquitin-protein ligase, which mediates ubiquitination and subsequent proteasomal degradation of proteins containing phosphotyrosine binding (PTB) domains. This protein may play an important role in tumorogenesis. Alternatively spliced transcript variants encoding distinct isoforms have been described. A pseudogene, which is located on chromosome 17, has been identified for this gene.
• Uniprot ID: Q8TBB1-2
• Protein Accession #: NP_116011
• Nucleotide Accession #: NM_032622
• Protein Size (# AA): 632
• Molecular Weight: 70kDa
• Protein Interactions: GRB2; TRIP13; ZCCHC10; ROPN1; NECAB2; PRR13; ZNF581; APIP; MEMO1; ZNF593; OSGIN1; NME7; OSBP2; DNPEP; ISCU; MTUS2; RUVBL2; NEK6; RFPL3; AIDA; GDI1; ROBO3; PBLD; LSM2; HOMEZ; TRIM54; AGTRAP; LGALS14; TRIM39; NXT2; ZFP64; POMGNT1; GOLPH3L; TRMT12; FAM118A;