Catalog No: ARP34122_T100
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ARP34122_T100
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LIG4 Antibody - N-terminal region (ARP34122_T100)

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Datasheets/ManualsPrintable datasheet for anti-LIG4 (ARP34122_T100) antibody
Product Info
Tested Species ReactivityHuman
Predicted Species ReactivityHuman, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit
Product FormatLiquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
ClonalityPolyclonal
HostRabbit
ApplicationIHC, WB
Reconstitution and StorageFor short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
ImmunogenThe immunogen is a synthetic peptide directed towards the N terminal region of human LIG4
PurificationProtein A purified
Predicted Homology Based on Immunogen SequenceCow: 92%; Dog: 93%; Guinea Pig: 93%; Horse: 86%; Human: 100%; Mouse: 92%; Rabbit: 93%; Rat: 93%
Peptide SequenceSynthetic peptide located within the following region: DGERMQMHKDGDVYKYFSRNGYNYTDQFGASPTEGSLTPFIHNAFKADIQ
Concentration1.0 mg/ml
Blocking PeptideFor anti-LIG4 (ARP34122_T100) antibody is Catalog # AAP34122 (Previous Catalog # AAPP05331)
ReferenceSmith,J., et al., (2003) Nucleic Acids Res. 31 (8), 2157-2167
Gene SymbolLIG4
Gene Full NameLigase IV, DNA, ATP-dependent
Alias SymbolsLIG4S
NCBI Gene Id3981
Protein NameDNA ligase 4
Description of TargetLIG4 encodes a DNA ligase that joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. This protein is essential for V(D)J recombination and DNA double-strand break (DSB) repair through nonhomologous end joining (NHEJ). This protein forms a complex with the X-ray repair cross complementing protein 4 (XRCC4), and further interacts with the DNA-dependent protein kinase (DNA-PK). Both XRCC4 and DNA-PK are known to be required for NHEJ. The crystal structure of the complex formed by this protein and XRCC4 has been resolved. Defects in this gene are the cause of LIG4 syndrome.
Uniprot IDQ8IY66
Protein Accession #NP_002303
Nucleotide Accession #NM_002312
Protein Size (# AA)911
Molecular Weight104kDa
Protein InteractionsXRCC4; UBC; AGO2; GZMK; ZSCAN18; PHF10; PNKP; TSFM; PRKDC; GUSBP3; NOMO3; FBLL1; PGP; ASPM; AMZ2P1; PPP1R18; COMMD1; ZNF428; AGAP4; WDR20; RPS19BP1; ZFAND2A; FIP1L1; CCDC176; VKORC1; COA7; SOWAHC; SEMA4G; ALMS1; WARS; UBE2L3; UBB; TPT1; TPI1; TP53BP1; TLE
  1. What is the species homology for "LIG4 Antibody - N-terminal region (ARP34122_T100)"?

    The tested species reactivity for this item is "Human". This antibody is predicted to have homology to "Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit".

  2. How long will it take to receive "LIG4 Antibody - N-terminal region (ARP34122_T100)"?

    This item is available "Domestic: within 1-2 days delivery | International: 1-2 days".

  3. What buffer format is "LIG4 Antibody - N-terminal region (ARP34122_T100)" provided in?

    This item is provided in "Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "LIG4 Antibody - N-terminal region (ARP34122_T100)"?

    This target may also be called "LIG4S" in publications.

  5. What is the shipping cost for "LIG4 Antibody - N-terminal region (ARP34122_T100)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "LIG4 Antibody - N-terminal region (ARP34122_T100)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "LIG4 Antibody - N-terminal region (ARP34122_T100)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "104kDa".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "LIG4 Antibody - N-terminal region (ARP34122_T100)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "LIG4"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "LIG4"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "LIG4"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "LIG4"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "LIG4"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "LIG4"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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