KLRC1 Antibody (OAGA00688)

Catalog No: OAGA00688

Size:100 ul

Sample (30 ug of whole cell lysate)
A: A431
B: Hep G2
12% SDS PAGE
NKG2-A (CD159a) antibody
OAGA00688 diluted at 1:1000

KLRC1 antibody [N1N2], N-term detects KLRC1 protein at cytosol on H1299 xenograft by immunohistochemical analysis.
Sample: Paraffin-embedded H1299 xenograft.
KLRC1 antibody [N1N2], N-term (OAGA00688) dilution: 1:500.

Immunofluorescence analysis of methanol-fixed HeLa, using KLRC1(OAGA00688) antibody at 1:200 dilution.

Product Info

• Predicted Species Reactivity: Human
• Product Format: Liquid
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Application: ICC, IF, IHC-FFPE, WB
• Additional Information: Background: Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor family, also called NKG2 family, which is a group of transmembrane proteins preferentially expressed in NK cells. This family of proteins is characterized by the type II membrane orientation and the presence of a C-type lectin domain. This protein forms a complex with another family member, KLRD1/CD94, and has been implicated in the recognition of the MHC class I HLA-E molecules in NK cells. The genes of NKG2 family members form a killer cell lectin-like receptor gene cluster on chromosome 12. Four alternatively spliced transcript variants encoding two distinct isoforms have been observed. [provided by RefSeq]
  Positive Controls: A431, HepG2
  Cellular Localization: Membrane; Single-pass type II membrane protein
• Reconstitution and Storage: Keep as concentrated solution. Aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.
• Immunogen: Synthetic peptide corresponding to a region within amino acids 1 and 45 of KLRC1 (Uniprot ID#P26715)
• Purification: Purified by antigen-affinity chromatography.
• Concentration: 0.54 mg/ml
• Application Info: Suggested starting dilutions are as follows: WB: 1:500-1:3000, IHC-P: 1:100-1:1000, ICC/IF: 1:100-1:1000. Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user.
• Storage Buffer: 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.

Target Info

• Gene Symbol: KLRC1
• Gene Full Name: NKG2-A/NKG2-B type II integral membrane protein
• Alias Symbols: NKG2, NKG2A, CD159A
• NCBI Gene Id: 3821
• Protein Name: NKG2-A/NKG2-B type II integral membrane protein
• Uniprot ID: P26715
• Protein Accession #: NP_002250.1
• Molecular Weight: 26 kDa