KIF2A antibody - N-terminal region (ARP33902_P050)

Catalog#: ARP33902_P050

• Size: 50ug

Human HepG2

Human Thymus

• Description of Target: KIF2A belongs to the kinesin-like protein family, MCAK/KIF2 subfamily. It contains 1 kinesin-motor domain. KIF2A plus end-directed microtubule-dependent motor required for normal brain development. It may regulate microtubule dynamics during axonal growth. KIF2A is implicated in formation of bipolar mitotic spindles. It has microtubule depolymerization activity. Hela cells lacking KIF2A show asymmetric or monopolar mitotic spindles. Osteosarcoma cells (U2OS) lacking KIF2A or KIF2B show disorganised or monopolar mitotic spindles.Kinesins, such as KIF2, are microtubule-associated motor proteins. For background information on kinesins, see MIM 148760.[supplied by OMIM].
• Gene Symbol: KIF2A
• Official Gene Full Name: Kinesin heavy chain member 2A
• Alias Symbols: HK2; KIF2
• Protein Accession#: NP_004511
• Nucleotide Accession#: NM_004520
• Swissprot Id: O00139
• Host: Rabbit
• Clonality: Polyclonal
• Protein Size (# AA): 706
• Molecular Weight: 80kDa
• Application: WB
• Partner Proteins: PLEKHM2, TRAK1, KIF5A, KLC3, KTN1, NCOA2, NDRG1, RRBP1, SNAP23, SNAP25, SYBU, YWHAB, YWHAG, YWHAQ, YWHAZ, DTNB, KIF5C, KLC1, KLC2, MARK2, MEPCE, NME2, SFN, SNAP23, SNAP25, USPL1, VDAC1, YWHAB, YWHAG, YWHAH, YWHAQ, YWHAZ
• Immunogen: The immunogen for anti-KIF2A antibody: synthetic peptide directed towards the N terminal of human KIF2A
• Product Format: Lyophilized powder
• Purification: Affinity Purified
• Predicted Homology Based on Immunogen Sequence: Human: 100%; Dog: 92%; Guinea pig: 92%; Rabbit: 92%; Rat: 92%; Bovine: 85%; Horse: 85%; Mouse: 78%
• Peptide Sequence: Synthetic peptide located within the following region: IEPSPETPPPPASSAKVNKIVKNRRTVASIKNDPPSRDNRVVGSARARPS
• Blocking Peptide: For anti-KIF2A antibody is Catalog # AAP33902 (Previous Catalog # AAPP04973)
• Key Reference: Jang,C.Y., (2008) J. Cell Biol. 181 (2), 255-267
• Reconstitution and Storage: Add 50 μl of distilled water. Final anti-KIF2A antibody concentration is 1 mg/ml in PBS buffer. For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.

Product Protocols: KIF2A antibody tested with Human Hepg2 Cells (ARP33902_P050)

Aviva Systems Biology is the original manufacturer of this KIF2A antibody (ARP33902_P050)

Click here to view the KIF2A antibody Western Blot Protocol

Product Datasheet Link: KIF2A antibody (ARP33902_P050)

WB Suggested Anti-KIF2A Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:312500
Positive Control: HepG2

Western Blot image:


Description of Target: KIF2A belongs to the kinesin-like protein family, MCAK/KIF2 subfamily. It contains 1 kinesin-motor domain. KIF2A plus end-directed microtubule-dependent motor required for normal brain development. It may regulate microtubule dynamics during axonal growth. KIF2A is implicated in formation of bipolar mitotic spindles. It has microtubule depolymerization activity. Hela cells lacking KIF2A show asymmetric or monopolar mitotic spindles. Osteosarcoma cells (U2OS) lacking KIF2A or KIF2B show disorganised or monopolar mitotic spindles.Kinesins, such as KIF2, are microtubule-associated motor proteins. For background information on kinesins, see MIM 148760.[supplied by OMIM].

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Aviva Systems Biology’s KIF2A antibody (ARP33902_P050) has been tested using other cell lysates and tissues. To obtain more data about this antibody please email us at info@avivasysbio.com.

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