KDM5A Antibody (OACA03185)

Catalog No: OACA03185

Immunohistochemistry of paraffin-embedded human prostate cancer at dilution of 1:100

Immunohistochemistry of paraffin-embedded human prostate cancer at dilution of 1:100

Product Info

• Predicted Species Reactivity: Human
• Product Format: Liquid
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Conjugation: Unconjugated
• Application: Enzyme-linked immunosorbent assay|Immunofluorescence|Immunohistochemistry
• Reconstitution and Storage: -20°C or -80°C
• Immunogen: Recombinant Human Lysine-specific demethylase 5A protein (437-603AA)
• Purification: Protein G Purified
• Preservative: 0.03% Proclin 300
• Formulation: 50% Glycerol, 0.01M PBS, PH 7.4
• Reference: [1]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.

Target Info

• Gene Symbol: KDM5A
• Gene Full Name: lysine demethylase 5A
• Alias Symbols: [histone H3]-trimethyl-L-lysine(4) demethylase 5A;histone demethylase JARID1A;Jumonji, AT rich interactive domain 1A (RBP2-like);jumonji/ARID domain-containing protein 1A;lysine (K)-specific demethylase 5A;lysine-specific demethylase 5A;RBBP2;RBBP-2;RBP2;retinoblastoma binding protein 2;Retinoblastoma-binding protein 2.
• NCBI Gene Id: 5927
• Protein Name: Lysine-specific demethylase 5A
• Description of Target: Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Regulates specific gene transcription through DNA-binding on 5'-CCGCCC-3' motif (PubMed:18270511). May stimulate transcription mediated by nuclear receptors. Involved in transcriptional regulation of Hox proteins during cell differentiation (PubMed:19430464). May participate in transcriptional repression of cytokines such as CXCL12. Plays a role in the regulation of the circadian rhythm and in maintaining the normal periodicity of the circadian clock. In a histone demethylase-independent manner, acts as a coactivator of the CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER1/2 and other clock-controlled genes and increases histone acetylation at PER1/2 promoters by inhibiting the activity of HDAC1 (By similarity). Seems to act as a transcriptional corepressor for some genes such as MT1F and to favor the proliferation of cancer cells (PubMed:27427228).
• Uniprot ID: P29375
• Protein Accession #: NP_001036068
• Nucleotide Accession #: NM_001042603