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Now Offering Over 85,203 Antibodies & 34,301 Antigens!

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KDM5A Antibody (OABF00801)

Description of Target:
Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. May stimulate transcription mediated by nuclear receptors. May be involved in transcriptional regulation of Hox proteins during cell differentiation. May participate in transcriptional repression of cytokines such as CXCL12. Plays a role in the regulation of the circadian rhythm and in maintaining the normal periodicity of the circadian clock. In a histone demethylase-independent manner, acts as a coactivator of the CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER1/2 and other clock-controlled genes and increases histone acetylation at PER1/2 promoters by inhibiting the activity of HDAC1 (By similarity).
Gene Symbol:
KDM5A
Official Gene Full Name:
lysine (K)-specific demethylase 5A
NCBI Gene Id:
5927
Alias Symbols:
RBP2; RBBP2; RBBP-2;
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express KDM5A.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express KDM5A.
Swissprot Id:
P29375
Host:
Rabbit
Clonality:
Polyclonal
Application:
IHC-P, IF
Conjugation:
Unconjugated
Immunogen:
KLH conjugated synthetic peptide derived from human KDM5A
Product Format:
Liquid. Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide.
Concentration:
1ug/ul
Purification:
Purified by Protein A.
Isotype:
IgG
Species Reactivity:
Human, Mouse, Rat
Datasheets / Downloads:
OABF00801
Applications Info:
IHC-P(1:100-500)
IF(1:50-200)
Additional Information:
Subcellular location: Nucleus
Reconstitution and Storage:
Store at -20C for 12 months.
Protocol:
Tips Information:
 
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