JMJD3 Antibody - N-terminal region (ARP40101_P050)

Catalog No: ARP40101_P050

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WB Suggested Anti-JMJD3 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:312500
Positive Control: Human Lung

Product Info

• Tested Species Reactivity: Human
• Predicted Species Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Clonality: Polyclonal
• Host: Rabbit
• Application: WB
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human JMJD3
• Purification: Affinity Purified
• Predicted Homology Based on Immunogen Sequence: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 93%; Rabbit: 100%; Rat: 100%
• Peptide Sequence: Synthetic peptide located within the following region: HRAVDPPGARAAREAFALGGLSCAGAWSSCPPHPPPRSAWLPGGRCSASI
• Concentration: 0.5 mg/ml
• Blocking Peptide: For anti-KDM6B (ARP40101_P050) antibody is Catalog # AAP40101 (Previous Catalog # AAPP22939)
• Reference: Hong,S., (2007) Proc. Natl. Acad. Sci. U.S.A. 104 (47), 18439-18444
• Publications:

  Lkb1 inactivation drives lung cancer lineage switching governed by Polycomb Repressive Complex 2. Nat Commun. 8, 14922 (2017). 28387316

• Description:
  View product citations for JMJD3 Antibody - N-terminal region (ARP40101_P050) on CiteAb

Target Info

• Gene Symbol: KDM6B
• Gene Full Name: Lysine (K)-specific demethylase 6B
• Alias Symbols: JMJD3, NEDCFSA
• NCBI Gene Id: 23135
• Protein Name: Lysine-specific demethylase 6B
• Description of Target: JMJD3 is a histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code. It plays a central role in regulation of posterior development, by regulating HOX gene expression. It is involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation.
• Uniprot ID: O15054
• Protein Accession #: NP_001073893
• Nucleotide Accession #: NM_001080424
• Protein Size (# AA): 1682
• Molecular Weight: 181kDa
• Protein Interactions: WDR5; ASH2L; RBBP5; UBC; TK1; CSNK2B; HIST1H3A; WAS; SMAD3; SMAD2; SMAD4; SMAD1;