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Datasheets/Manuals | Printable datasheet for ITGAX Antibody (OAEE00620) (OAEE00620) |
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Predicted Species Reactivity | Human|Monkey |
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Product Format | Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide |
Clonality | Monoclonal |
Clone | BU15 |
Isotype | IgG1 |
Host | Mouse |
Conjugation | FITC |
Application | Flow cytometry |
Reconstitution and Storage | 2°C to 8°C |
Immunogen | Dendritic cells of synovial fluid |
Purification | Purified by size-exclusion chromatography |
Concentration | 20 ul / test |
Specificity | The antibody BU15 reacts with CD11c (alphaX, p150), a 150 kDa integrin expressed mainly on dendritic cells and tissue macrophages. HLDA III; WS Code M 256 HLDA V; WS Code AS S143 HLDA VI; WS Code AS Ref.6 |
Formulation | FITC |
Storage Buffer | The reagent is provided in phosphate buffered saline (PBS) containing 15 mM sodium azide and 0.2% (w/v) high-grade protease free Bovine Serum Albumin (BSA) as a stabilizing agent. |
Reference | Rezzonico R, Imbert V, Chicheportiche R, Dayer JM: Ligation of CD11b and CD11c beta(2) integrins by antibodies or soluble CD23 induces macrophage inflammatory protein 1alpha (MIP-1alpha) and MIP-1beta production in primary human monocytes through a pathway dependent on nuclear factor-kappaB. Blood. 2001 May 15;97(10):2932-40. And many other. Angel CE, Lala A, Chen CJ, Edgar SG, Ostrovsky LL, Dunbar PR: CD14+ antigen-presenting cells in human dermis are less mature than their CD1a+ counterparts. Int Immunol. 2007 Nov;19(11):1271-9. Leukocyte Typing III., McMichael A. J. et al (Eds.), Oxford University Press (1987). Leukocyte Typing V., Schlossman S. et al. (Eds.), Oxford University Press (1995). Leukocyte Typing VI., Kishimoto T. et al. (Eds.), Garland Publishing Inc. (1997). Sadhu C, Hendrickson L, Dick KO, Potter TG, Staunton DE: Novel Tools for Functional Analysis of CD11c: Activation-Specific, Activation-Independent, and Activating Antibodies. J Immunoassay Immunochem. 2008;29(1):42-57. Myou S, Zhu X, Boetticher E, Qin Y, Myo S, Meliton A, Lambertino A, Munoz NM, Hamann KJ, Leff AR: Regulation of adhesion of AML14.3D10 cells by surface clustering of beta2-integrin caused by ERK-independent activation of cPLA2. Immunology. 2002 Sep;107(1):77-85. Van der Vieren M, Le Trong H, Wood CL, Moore PF, St John T, Staunton DE, Gallatin WM: A novel leukointegrin, alpha d beta 2, binds preferentially to ICAM-3. Immunity. 1995 Dec;3(6):683-90. Trowald-Wigh G, Johannisson A, Håkansson L: Canine neutrophil adhesion proteins and Fc-receptors in healthy dogs and dogs with adhesion protein deficiency, as studied by flow cytometry. Vet Immunol Immunopathol. 1993 Oct;38(3-4):297-310. Hogg N, Takacs L, Palmer DG, Selvendran Y, Allen C: The p150,95 molecule is a marker of human mononuclear phagocytes: comparison with expression of class II molecules. Eur J Immunol. 1986 Mar;16(3):240-8. Bullard DC, Hu X, Adams JE, Schoeb TR, Barnum SR: p150/95 (CD11c/CD18) expression is required for the development of experimental autoimmune encephalomyelitis. Am J Pathol. 2007 Jun;170(6):2001-8. Sadhu C, Ting HJ, Lipsky B, Hensley K, Garcia-Martinez LF, Simon SI, Staunton DE: CD11c/CD18: novel ligands and a role in delayed-type hypersensitivity. J Leukoc Biol. 2007 Jun;81(6):1395-403. Gang J, Choi J, Lee JH, Nham SU: Identification of critical residues for plasminogen binding by the alphaXI-domain of the beta2 integrin, alphaXbeta2. Mol Cells. 2007 Oct 31;24(2):240-6. Vorup-Jensen T, Chi L, Gjelstrup LC, Jensen UB, Jewett CA, Xie C, Shimaoka M, Linhardt RJ, Springer TA: Binding between the integrin alphaXbeta2 (CD11c/CD18) and heparin. J Biol Chem. 2007 Oct 19;282(42):30869-77. |
Gene Symbol | ITGAX |
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Gene Full Name | integrin subunit alpha X |
Alias Symbols | CD11 antigen-like family member C;CD11C;complement component 3 receptor 4 subunit;integrin alpha X;integrin alpha-X;integrin, alpha X (antigen CD11C (p150), alpha polypeptide);integrin, alpha X (complement component 3 receptor 4 subunit);Leu M5;leu M5, alpha subunit;leukocyte adhesion glycoprotein p150,95 alpha chain;leukocyte adhesion receptor p150,95;leukocyte surface antigen p150,95, alpha subunit;myeloid membrane antigen, alpha subunit;p150 95 integrin alpha chain;SLEB6. |
NCBI Gene Id | 3687 |
Protein Name | Integrin alpha-X |
Description of Target | Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis. |
Uniprot ID | P20702 |
Protein Accession # | NP_000878.2; NP_001273304.1 |
Nucleotide Accession # | NM_000887.4; NM_001286375.1 |
- Protocol:
- Reconstitution & Storage Instructions
- Western Blotting/Immunoblotting (WB/IB) Protocol
- Immunohistochemistry (IHC) Protocol
- Immunocytochemistry (ICC) Protocol
- Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
- Blocking Peptide Competition Protocol (BPCP)
- Immunoprecipitation (IP) Protocol
- Antibody Array (AA) Protocol
- Tips Information:
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See our General FAQ page.
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What is the species homology for "ITGAX Antibody (OAEE00620)"?
The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human|Monkey".
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How long will it take to receive "ITGAX Antibody (OAEE00620)"?
This item is available "Domestic: within 1-2 week delivery | International: 1-2 weeks".
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What buffer format is "ITGAX Antibody (OAEE00620)" provided in?
This item is provided in "Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide".
Additional format options may be available. For more information please contact info@avivasysbio.com. -
What are other names for "ITGAX Antibody (OAEE00620)"?
This target may also be called "CD11 antigen-like family member C;CD11C;complement component 3 receptor 4 subunit;integrin alpha X;integrin alpha-X;integrin, alpha X (antigen CD11C (p150), alpha polypeptide);integrin, alpha X (complement component 3 receptor 4 subunit);Leu M5;leu M5, alpha subunit;leukocyte adhesion glycoprotein p150,95 alpha chain;leukocyte adhesion receptor p150,95;leukocyte surface antigen p150,95, alpha subunit;myeloid membrane antigen, alpha subunit;p150 95 integrin alpha chain;SLEB6." in publications.
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What is the shipping cost for "ITGAX Antibody (OAEE00620)"?
The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.
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What is the guarantee for "ITGAX Antibody (OAEE00620)"?
All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.
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Can I get bulk pricing for "ITGAX Antibody (OAEE00620)"?
You can get bulk pricing for this item by going here.
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What is the molecular weight of the protein?
The molecular weight reported by Uniprot for this item is "".
Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics. -
What protocols are available for "ITGAX Antibody (OAEE00620)"?
We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.
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What are positive controls for "ITGAX"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What are negative controls for "ITGAX"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What other proteins interact with "ITGAX"?
This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.
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What biological processes are associated with "ITGAX"?
This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.
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What cellular components are associated with "ITGAX"?
This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.
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What protein functions are associated with "ITGAX"?
This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.