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Catalog No: OAAB03314
Size:400ul
Price: $438.00
SKU
OAAB03314
Availability: Domestic: within 1-2 week delivery | International: within 1-2 week delivery
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  • $55: Antibody & Protein in US
  • $55 + $25/Kit in US
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HEY2 Antibody - N-terminal region (OAAB03314)

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Datasheets/ManualsPrintable datasheet for anti-HEY2 antibody - OAAB03314
Product Info
Predicted Species ReactivityHuman, Mouse
Product FormatLiquid. PBS with 0.09% (W/V) sodium azide.
ClonalityPolyclonal
IsotypeIg
HostRabbit
ApplicationWB, IHC-P
Additional InformationFunction: Downstream effector of Notch signaling which may be required for cardiovascular development. Transcriptional repressor which binds preferentially to the canonical E box sequence 5'- CACGTG-3'. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6.
Cellular Location: Nucleus
Reconstitution and StorageMaintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
ImmunogenThis HEY2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 65-91 amino acids from the N-terminal region of human HEY2.
PurificationThis antibody is purified through a protein A column, followed by peptide affinity purification.
Predicted Homology Based on Immunogen SequenceCow; Human; Mouse; Zebrafish; Xenopus; Drosophila
ConcentrationApproximately 0.5mg/ml. Actual concentration varies with each lot.
Application InfoWB: 1:1000
IHC-P: 1:50~100
Gene SymbolHEY2
Alias SymbolsGRL, CHF1, HRT2, HERP1, HESR2, bHLHb32, GRIDLOCK
NCBI Gene Id23493
Protein NameHairy/enhancer-of-split related with YRPW motif protein 2
Uniprot IDQ9UBP5
Protein Accession #NP_036391.1
Molecular Weight35808 Da
Protocol:
Tips Information:

See our General FAQ page.

Protein interactions
Name# of Products
ARNT64
BTRC289
CASP3324
HAND127
HAND222
HDAC1928
HDAC994
HES1107
HEY217
NCOR1286
PLSCR1137
SIN3A346
SIRT1310
Biological pathways
Name# of Products
Cardiac ventricle morphogenesis3
Negative regulation of transcription from RNA polymerase II promoter682
Negative regulation of transcription initiation from RNA polymerase II promoter3
Negative regulation of transcription regulatory region DNA binding15
Notch signaling pathway129
Vascular smooth muscle cell development6
Ventricular cardiac muscle cell development4
Biological process
Name# of Products
Anterior/posterior axis specification9
Artery development8
Atrioventricular valve development1
Cardiac muscle hypertrophy in response to stress3
Cardiac vascular smooth muscle cell development1
Cardiac ventricle morphogenesis5
Cell fate commitment44
Cochlea development17
Coronary vasculature morphogenesis2
Endocardial cushion to mesenchymal transition involved in heart valve formation3
Negative regulation of cardiac muscle cell apoptosis9
Negative regulation of cardiac vascular smooth muscle cell differentiation1
Negative regulation of gene expression70
Negative regulation of Notch signaling pathway13
Negative regulation of transcription by transcription factor localization3
Negative regulation of transcription from RNA polymerase II promoter574
Negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation4
Negative regulation of transcription initiation from RNA polymerase II promoter1
Negative regulation of transcription regulatory region DNA binding13
Negative regulation of transcription, DNA-dependent520
Notch signaling pathway95
Pattern specification process111
Positive regulation of cardiac muscle cell proliferation24
Positive regulation of heart rate11
Protein-DNA complex assembly3
Regulation of auditory receptor cell differentiation1
Smooth muscle cell differentiation16
Tricuspid valve formation3
Vascular smooth muscle cell development4
Vasculogenesis60
Ventricular cardiac muscle cell development12
Ventricular trabecula myocardium morphogenesis5
Cellular components
Name# of Products
Cytoplasm4549
Nucleus4914
Sin3 complex10
Transcriptional repressor complex43
Protein function
Name# of Products
DNA binding3958
Histone deacetylase binding181
Microsatellite binding8
Protein binding12191
Protein binding transcription factor activity43
RNA polymerase II activating transcription factor binding98
RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity36
Sequence-specific DNA binding1803
Sequence-specific DNA binding transcription factor activity2776
Transcription factor binding934

  1. What is the species homology for "HEY2 Antibody - N-terminal region (OAAB03314)"?

    The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human, Mouse".

  2. How long will it take to receive "HEY2 Antibody - N-terminal region (OAAB03314)"?

    This item is available "Domestic: within 1-2 week delivery | International: within 1-2 week delivery".

  3. What buffer format is "HEY2 Antibody - N-terminal region (OAAB03314)" provided in?

    This item is provided in "Liquid. PBS with 0.09% (W/V) sodium azide. ".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "HEY2 Antibody - N-terminal region (OAAB03314)"?

    This target may also be called "GRL, CHF1, HRT2, HERP1, HESR2, bHLHb32, GRIDLOCK" in publications.

  5. What is the shipping cost for "HEY2 Antibody - N-terminal region (OAAB03314)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "HEY2 Antibody - N-terminal region (OAAB03314)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "HEY2 Antibody - N-terminal region (OAAB03314)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "35808 Da".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "HEY2 Antibody - N-terminal region (OAAB03314)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "HEY2"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "HEY2"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "HEY2"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "HEY2"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "HEY2"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "HEY2"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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