HDAC1 Antibody - middle region (ARP32358_P050)

Catalog No: ARP32358_P050

WB Suggested Anti-HDAC1 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:2500
Positive Control: Jurkat cell lysateHDAC1 is supported by BioGPS gene expression data to be expressed in Jurkat

Host: Rabbit
Target Name: HDAC1
Sample Type: Human Fetal Heart
Antibody Dilution: 1.0ug/ml

Host: Rabbit
Target Name: HDAC1
Sample Type: Human Fetal Liver
Antibody Dilution: 1.0ug/ml

Host: Rabbit
Target Name: HDAC1
Sample Type: Human Fetal Lung
Antibody Dilution: 1.0ug/ml

Host: Rabbit
Target Name: HDAC1
Sample Type: Human Adult Placenta
Antibody Dilution: 1.0ug/ml

Rabbit Anti-HDAC1 antibody
Catalog Number: ARP32358_P050
Paraffin Embedded Tissue: Human Heart cell
Cellular Data: Epithelial cells of renal tubule
Antibody Concentration: 4.0-8.0 ug/ml
Magnification: 400X

Product Info

• Tested Species Reactivity: Human
• Predicted Species Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Yeast, Zebrafish
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Clonality: Polyclonal
• Host: Rabbit
• Application: IHC, WB
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human HDAC1
• Purification: Affinity Purified
• Predicted Homology Based on Immunogen Sequence: Cow: 93%; Dog: 93%; Guinea Pig: 93%; Horse: 93%; Human: 100%; Mouse: 93%; Rabbit: 93%; Rat: 93%; Yeast: 100%; Zebrafish: 86%
• Peptide Sequence: Synthetic peptide located within the following region: EKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICS
• Concentration: 0.5 mg/ml
• Blocking Peptide: For anti-HDAC1 (ARP32358_P050) antibody is Catalog # AAP32358 (Previous Catalog # AAPP03347)
• Sample Type Confirmation:

  HDAC1 is supported by BioGPS gene expression data to be expressed in Jurkat

• Reference: Oh,M., (2008) Biochem. Biophys. Res. Commun. 369 (4), 1179-1183

Target Info

• Gene Symbol: HDAC1
• Gene Full Name: Histone deacetylase 1
• Alias Symbols: HD1, RPD3, KDAC1, GON-10, RPD3L1
• NCBI Gene Id: 3065
• Protein Name: Histone deacetylase 1
• Description of Target: Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. HDAC1 belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis.Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
• Uniprot ID: Q13547
• Protein Accession #: NP_004955
• Nucleotide Accession #: NM_004964
• Protein Size (# AA): 482
• Molecular Weight: 55kDa
• Protein Interactions: BCL6; CUL4B; YY1; SIN3A; RCOR1; KDM1A; KAT5; NCOR2; SUMO1; DDIT3; DDB1; BCOR; SF3A1; TP53; SP1; SUMO2; NFKB1; NFE2L2; MDM2; SMAD3; SMAD1; JUN; CHFR; HIF1A; HDAC2; EP300; SAP130; UBC; RELA; RB1; RARA; PRDM6; HAUS2; FEZF2; BANP; WHSC1; ESR1; DNMT3B; DNMT1;