GRK6 Recombinant Protein (OPCD03687)

Catalog No: OPCD03687

GRK6 Recombinant Protein (OPCD03687) using SDS-PAGE

GRK6 Recombinant Protein (OPCD03687) using SDS-PAGE

Product Info

• Predicted Species Reactivity: Homo sapiens|Human
• Product Format: Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
• Host: E.coli
• Conjugation: Unconjugated
• Application: Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
• Additional Information: Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
  Residues: Phe186-Phe448
• Reconstitution and Storage: 2°C to 8°C|-80°C
• Concentration: 200 ug/mL (prior to lyoph)
• Purity: > 95%
• Source: E.coli
• Tag: N-terminal His Tag

Target Info

• Gene Symbol: GRK6
• Gene Full Name: G protein-coupled receptor kinase 6
• Alias Symbols: G protein-coupled receptor kinase 6;G protein-coupled receptor kinase GRK6;GPRK6.
• NCBI Gene Id: 2870
• Protein Name: G protein-coupled receptor kinase 6
• Description of Target: Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (By similarity). Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro).
• Uniprot ID: P43250
• Protein Accession #: NP_001004105.1
• Nucleotide Accession #: NM_001004105.2
• Protein Size (# AA): Phe186~Phe448
• Molecular Weight: 34kDa