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- $55: Antibody & Protein in US
- $55 + $25/Kit in US
- Contact us for international orders.
Datasheets/Manuals | Printable datasheet for GRK6 Antibody (OACA07205) (OACA07205) |
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Predicted Species Reactivity | Human |
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Product Format | Liquid |
Clonality | Polyclonal |
Isotype | IgG |
Host | Rabbit |
Conjugation | Unconjugated |
Application | Enzyme-linked immunosorbent assay|Immunohistochemistry |
Reconstitution and Storage | -20°C or -80°C |
Immunogen | Recombinant Human G protein-coupled receptor kinase 6 protein (1-170AA) |
Purification | Affinity Purified |
Preservative | 0.02% sodium azide |
Formulation | PBS with, 50% glycerol, pH7.3. |
Reference | [1]"Patterns of somatic mutation in human cancer genomes."Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G. Stratton M.R. Nature 446:153-158(2007). [2]"Molecular basis for activation of G protein-coupled receptor kinases."Boguth C.A., Singh P., Huang C.C., Tesmer J.J.EMBO J. 29:3249-3259(2010). [3]"The structure of G protein-coupled receptor kinase (GRK)-6 defines a second lineage of GRKs."Lodowski D.T., Tesmer V.M., Benovic J.L., Tesmer J.J.J. Biol. Chem. 281:16785-16793(2006). |
Gene Symbol | GRK6 |
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Gene Full Name | G protein-coupled receptor kinase 6 |
Alias Symbols | G protein-coupled receptor kinase 6;G protein-coupled receptor kinase GRK6;GPRK6. |
NCBI Gene Id | 2870 |
Protein Name | G protein-coupled receptor kinase 6 |
Description of Target | Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (By similarity). Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro). |
Uniprot ID | P43250 |
Protein Accession # | NP_001004105 |
Nucleotide Accession # | NM_001004105 |
- Protocol:
- Reconstitution & Storage Instructions
- Western Blotting/Immunoblotting (WB/IB) Protocol
- Immunohistochemistry (IHC) Protocol
- Immunocytochemistry (ICC) Protocol
- Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
- Blocking Peptide Competition Protocol (BPCP)
- Immunoprecipitation (IP) Protocol
- Antibody Array (AA) Protocol
- Tips Information:
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See our General FAQ page.
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What is the species homology for "GRK6 Antibody (OACA07205)"?
The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human".
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How long will it take to receive "GRK6 Antibody (OACA07205)"?
This item is available "Domestic: Antibody & Kits: 2 weeks | Proteins: 4-6 weeks | International: Antibody & Kits: 2 weeks | Proteins: 4-6 weeks".
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What buffer format is "GRK6 Antibody (OACA07205)" provided in?
This item is provided in "Liquid".
Additional format options may be available. For more information please contact info@avivasysbio.com. -
What are other names for "GRK6 Antibody (OACA07205)"?
This target may also be called "G protein-coupled receptor kinase 6;G protein-coupled receptor kinase GRK6;GPRK6." in publications.
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What is the shipping cost for "GRK6 Antibody (OACA07205)"?
The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.
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What is the guarantee for "GRK6 Antibody (OACA07205)"?
All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.
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Can I get bulk pricing for "GRK6 Antibody (OACA07205)"?
You can get bulk pricing for this item by going here.
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What is the molecular weight of the protein?
The molecular weight reported by Uniprot for this item is "".
Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics. -
What protocols are available for "GRK6 Antibody (OACA07205)"?
We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.
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What are positive controls for "GRK6"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What are negative controls for "GRK6"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What other proteins interact with "GRK6"?
This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.
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What biological processes are associated with "GRK6"?
This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.
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What cellular components are associated with "GRK6"?
This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.
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What protein functions are associated with "GRK6"?
This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.