GRK6 Antibody - C-terminal (OAPB01846)

Catalog No: OAPB01846

Size:100UG

Western blot analysis of GRK6 in rat small intestine tissue lysate with GRK6 antibody at 1 ug/ml.

Product Info

• Predicted Species Reactivity: Human|Mouse|Rat
• Product Format: Liquid. GRK6 antibody is supplied in PBS containing 0.02% sodium azide.
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Conjugation: Unconjugated
• Application: Enzyme-linked immunosorbent assay|Immunofluorescence|Immunohistochemistry-Paraffin|Western blot
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: GRK6 antibody was raised against a 19 amino acid peptide near the carboxy terminus of human GRK6. The immunogen is located within the last 50 amino acids of GRK6.
• Purification: Affinity Purified
• Concentration: 1 mg/ml

Target Info

• Gene Symbol: GRK6
• Gene Full Name: G protein-coupled receptor kinase 6
• Alias Symbols: G protein-coupled receptor kinase 6;G protein-coupled receptor kinase GRK6;GPRK6.
• NCBI Gene Id: 2870
• Protein Name: G protein-coupled receptor kinase 6|G protein-coupled receptor kinase 6 isoform A [Homo sapiens]
• Description of Target: Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (By similarity). Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro).
• Uniprot ID: P43250
• Protein Accession #: https://www.ncbi.nlm.nih.gov/protein/NP_001004106
• Nucleotide Accession #: NM_001004105.2
• Molecular Weight: Predicted: 63 kDa Observed: 63 kDa