GRIA3 Antibody (OACA03067)

Catalog No: OACA03067

Immunohistochemistry of paraffin-embedded human gastric cancer at dilution 1:100

Immunohistochemistry of paraffin-embedded human gastric cancer at dilution 1:100

Product Info

• Predicted Species Reactivity: Human
• Product Format: Liquid
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Conjugation: Unconjugated
• Application: Enzyme-linked immunosorbent assay|Immunofluorescence|Immunohistochemistry
• Reconstitution and Storage: -20°C or -80°C
• Immunogen: Recombinant Human Glutamate receptor 3 protein (151-250AA)
• Purification: Protein G Purified
• Preservative: 0.03% Proclin 300
• Formulation: 50% Glycerol, 0.01M PBS, PH 7.4
• Reference: [1]"Mutations in ionotropic AMPA receptor 3 alter channel properties and are associated with moderate cognitive impairment in humans." Wu Y., Arai A.C., Rumbaugh G., Srivastava A.K., Turner G., Hayashi T., Suzuki E., Jiang Y., Zhang L., Rodriguez J., Boyle J., Tarpey P., Raymond F.L., Nevelsteen J., Froyen G., Stratton M., Futreal A., Gecz J. Wang T. Proc. Natl. Acad. Sci. U.S.A. 104:18163-18168(2006). [2]"Hippocampal AMPA receptor gating controlled by both TARP and cornichon proteins." Kato A.S., Gill M.B., Ho M.T., Yu H., Tu Y., Siuda E.R., Wang H., Qian Y.W., Nisenbaum E.S., Tomita S., Bredt D.S. Neuron 68:1082-1096(2009). [3]"Candidate gene analysis in Rett syndrome and the identification of 21 SNPs in Xq." Amir R., Dahle E.J., Toriolo D., Zoghbi H.Y. Am. J. Med. Genet. 90:69-71(1999).

Target Info

• Gene Symbol: GRIA3
• Gene Full Name: glutamate ionotropic receptor AMPA type subunit 3
• Alias Symbols: AMPA-selective glutamate receptor 3;dJ1171F9.1;GluA3;gluR-3;GLUR3;GLURC;GLUR-C;GLUR-K3;glutamate receptor 3;glutamate receptor C;Glutamate receptor ionotropic, AMPA 3;glutamate receptor subunit 3;glutamate receptor, ionotrophic, AMPA 3;glutamate receptor, ionotropic, AMPA 3;MRX94;MRXSW.
• NCBI Gene Id: 2892
• Protein Name: Glutamate receptor 3
• Description of Target: Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.
• Uniprot ID: P42263
• Protein Accession #: NP_000819
• Nucleotide Accession #: NM_000828