GH Antibody (OAAD00159)

Catalog No: OAAD00159

Size:100 ug

Product Info

• Predicted Species Reactivity: Human
• Clonality: Monoclonal
• Clone: GH-15
• Isotype: IgG1
• Host: Mouse
• Application: IHC, IP
• Reconstitution and Storage: At -20C for one year. After reconstitution, at 4C for one month. It can also be aliquotted and stored frozen at -20C for longer time.
• Immunogen: Recombinant hGH.
• Purification: Purified by the goat anti-mouse IgG Affinity chromatography.
• Specificity: Human.
  No cross reactivity with other proteins.
• Formulation: Lyophilized from 1.2% sodium acetate, with 2mg BSA and 0.01mg NaN3 as preservative.
• Application Info: Immunohistochemistry(P) At 2-4ug/ml to detect growth hormone in formalin fixed and paraffin embedded tissues.
  Other applications have not been tested.
  Optimal dilutions should be determined by end user.
• Storage Buffer: 1.2% sodium acetate or neutral PBS. If 1ml of PBS is used, the antibody concentration will be 100ug/ml.
• Reference: 1. Niall, H. D.; Hogan, M. L.; Sauer, R.; Rosenblum, I. Y.; Greenwood, F. C. : Sequence of pituitary and placental lactogenic and growth hormones: evolution from a primordial peptide by gene reduplication.
  Proc. Nat. Acad. Sci. 68: 866-869, 1971.
  2. Sundstrom, M.; Lundqvist, T.; Rodin, J.; Giebel, L. B.; Milligan, D.; Norstedt, G. : Crystal structure of an antagonist mutant of human growth hormone, G120R, in complex with its receptor at 2.9 angstrom resolution. J. Biol. Chem. 271: 32197-32203, 1996.

Target Info

• Gene Symbol: GH1
• Alias Symbols: GH, GHN, GH-N, GHB5, IGHD2, hGH-N, IGHD1A, IGHD1B
• NCBI Gene Id: 2688
• Protein Name: Somatotropin
• Description of Target: Growth Hormone (GH) is mapped to 17q22-q24. Human growth hormone has a molecular mass of 22, 005 and contains 191 amino acid residues with 2 disulfide bridges. It binds two receptor molecules and thereby induces signal transduction through receptor dimerization. At high concentrations, GH acts as an antagonist because of a large difference in affinities at the respective binding sites.
• Uniprot ID: P01241