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Now Offering Over 85,203 Antibodies & 34,301 Antigens!

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100 ul
$229.00
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GCDH antibody - C-terminal region (ARP43559_T100)

Description of Target:
GCDH belongs to the acyl-CoA dehydrogenase family. It catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO(2) in the degradative pathway of L-lysine, L-hydroxylysine, and L-tryptophan metabolism. It uses electron transfer flavoprotein as its electron acceptor. The enzyme exists in the mitochondrial matrix as a homotetramer of 45-kD subunits.The protein encoded by this gene belongs to the acyl-CoA dehydrogenase family. It catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO(2) in the degradative pathway of L-lysine, L-hydroxylysine, and L-tryptophan metabolism. It uses electron transfer flavoprotein as its electron acceptor. The enzyme exists in the mitochondrial matrix as a homotetramer of 45-kD subunits. Alternatively spliced transcript variants encoding different isoforms have been identified.
Gene Symbol:
GCDH
Official Gene Full Name:
Glutaryl-CoA dehydrogenase
NCBI Gene Id:
2639
Alias Symbols:
ACAD5; GCD
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express GCDH.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express GCDH.
Swissprot Id:
Q92947
Protein Accession #:
NP_000150
Nucleotide Accession #:
NM_000159
Host:
Rabbit
Clonality:
Polyclonal
Protein Name:
Glutaryl-CoA dehydrogenase, mitochondrial
Protein Size (# AA):
438
Molecular Weight:
48kDa
Application:
IHC, WB
Protein Interactions:
UBC; FBXO6; ADRB2; RNF32; EXOC6; ECSIT; MAST1; CDC37; PSEN2; PSEN1; NOS3; APOE; A2M; UBD; MYC; GCDH;
Immunogen:
The immunogen for anti-GCDH antibody: synthetic peptide directed towards the C terminal of human GCDH
Product Format:
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Concentration:
Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
Purification:
Protein A purified
Complete computational species homology data:
GCDH antibody - C-terminal region (ARP43559_T100)
Predicted Homology Based on Immunogen Sequence:
Dog: 100%; Pig: 100%; Rat: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Zebrafish: 100%
Species Reactivity:
Human, Rat, Dog, Horse, Rabbit, Pig, Mouse, Zebrafish
Datasheets / Downloads:
Printable datasheet for
anti-GCDH antibody
- ARP43559_T100
Peptide Sequence:
Synthetic peptide located within the following region: IARQARDMLGGNGISDEYHVIRHAMNLEAVNTYEGTHDIHALILGRAITG
Blocking Peptide:
For anti-GCDH antibody is Catalog # AAP43559 (Previous Catalog # AAPP25004)
Additional Information:
IHC Information: HepG2 cell lysate. Antibody concentration: 2.5 ug/ml. Gel concentration: 12%.
Target Reference:
Kimura,K., (2006) Genome Res. 16 (1), 55-65
Reconstitution and Storage:
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Publications:

Hu, Z. et al. Quantitative liver-specific protein fingerprint in blood: a signature for hepatotoxicity. Theranostics 4, 215-28 (2014). WB, Human, Rat, Dog, Horse, Rabbit, Pig, Mouse, Zebrafish 24465277

Product Protocols: GCDH antibody tested by IHC with human muscle (ARP43559)

Aviva Systems Biology is the original manufacturer of this GCDH antibody.

Click here to view the GCDH antibody Immunohistochemistry (IHC) protocol

Product Datasheet Link: GCDH antibody (ARP43559)

IHC Information:

Rabbit Anti-GCDH Antibody
Catalog Number: ARP43559
Paraffin Embedded Tissue: Human Muscle
Cellular Data: Skeletal muscle cells
Antibody Concentration: 4.0-8.0 ug/ml
Magnification: 400X

IHC Image:

 
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