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GCDH antibody - C-terminal region (ARP43559_T100)

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100 ul

Regular Price: $229.00

Special Price: $185.00

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Conjugation Options

ARP43559_T100-FITC Conjugated

ARP43559_T100-HRP Conjugated

ARP43559_T100-Biotin Conjugated

Gene Symbol:
GCDH
NCBI Gene Id:
2639
Official Gene Full Name:
Glutaryl-CoA dehydrogenase
Protein Name:
Glutaryl-CoA dehydrogenase, mitochondrial
Swissprot Id:
Q92947
Protein Accession #:
NP_000150
Nucleotide Accession #:
NM_000159
Alias Symbols:
ACAD5, GCD
Replacement Item:
This antibody may replace item sc-133610 from Santa Cruz Biotechnology.
Description of Target:
GCDH belongs to the acyl-CoA dehydrogenase family. It catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO(2) in the degradative pathway of L-lysine, L-hydroxylysine, and L-tryptophan metabolism. It uses electron transfer flavoprotein as its electron acceptor. The enzyme exists in the mitochondrial matrix as a homotetramer of 45-kD subunits.The protein encoded by this gene belongs to the acyl-CoA dehydrogenase family. It catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO(2) in the degradative pathway of L-lysine, L-hydroxylysine, and L-tryptophan metabolism. It uses electron transfer flavoprotein as its electron acceptor. The enzyme exists in the mitochondrial matrix as a homotetramer of 45-kD subunits. Alternatively spliced transcript variants encoding different isoforms have been identified.
Protein Size (# AA):
438
Molecular Weight:
48kDa
Host:
Rabbit
Clonality:
Polyclonal
Purification:
Protein A purified
Application:
IHC, WB
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express GCDH.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express GCDH.
Immunogen:
The immunogen is a synthetic peptide directed towards the C terminal region of human GCDH
Species Reactivity:
Dog, Horse, Human, Mouse, Pig, Rabbit, Rat, Zebrafish
Predicted Homology Based on Immunogen Sequence:
Dog: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100%
Complete computational species homology data:
Anti-GCDH (ARP43559_T100)
Peptide Sequence:
Synthetic peptide located within the following region: IARQARDMLGGNGISDEYHVIRHAMNLEAVNTYEGTHDIHALILGRAITG
Product Format:
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution and Storage:
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Concentration:
Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
Protein Interactions:
UBC; FBXO6; ADRB2; RNF32; EXOC6; ECSIT; MAST1; CDC37; PSEN2; PSEN1; NOS3; APOE; A2M; UBD; MYC; GCDH;
Blocking Peptide:
For anti-GCDH (ARP43559_T100) antibody is Catalog # AAP43559 (Previous Catalog # AAPP25004)
Datasheets / Downloads:
Printable datasheet for anti-GCDH (ARP43559_T100) antibody
Additional Information:
IHC Information: HepG2 cell lysate. Antibody concentration: 2.5 ug/ml. Gel concentration: 12%.
Target Reference:
Kimura,K., (2006) Genome Res. 16 (1), 55-65
Publications:

Hu, Z. et al. Quantitative liver-specific protein fingerprint in blood: a signature for hepatotoxicity. Theranostics 4, 215-28 (2014). WB, Human, Rat, Dog, Horse, Rabbit, Pig, Mouse, Zebrafish 24465277

Product Protocols: GCDH antibody tested by IHC with human muscle (ARP43559)

Aviva Systems Biology is the original manufacturer of this GCDH antibody.

Click here to view the GCDH antibody Immunohistochemistry (IHC) protocol

Product Datasheet Link: GCDH antibody (ARP43559)

IHC Information:

Rabbit Anti-GCDH Antibody
Catalog Number: ARP43559
Paraffin Embedded Tissue: Human Muscle
Cellular Data: Skeletal muscle cells
Antibody Concentration: 4.0-8.0 ug/ml
Magnification: 400X

IHC Image:

 
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