FKBP5 Antibody - C-terminal region (ARP54713_P050)

Catalog No: ARP54713_P050

25 ug of the indicated Human whole cell extracts was loaded onto a 12% SDS-PAGE gel. 3 ug/mL of the antibody was used in this experiment. The protein may be modified by phosphorylation.

Host: Rabbit
Target Name: FKBP5
Sample Tissue: Mouse Heart
Antibody Dilution: 1ug/ml

Host: Mouse
Target Name: FKBP5
Sample Tissue: Mouse Heart
Antibody Dilution: 1ug/ml

Brain, cortex

Product Info

• Tested Species Reactivity: Human, Mouse
• Predicted Species Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Clonality: Polyclonal
• Host: Rabbit
• Application: IHC, WB
• Additional Information: IHC Information: Paraffin embedded brain, cortex tissue, tested with an antibody dilution of 2.5 ug/ml.
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human FKBP5
• Purification: Affinity Purified
• Predicted Homology Based on Immunogen Sequence: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 79%
• Peptide Sequence: Synthetic peptide located within the following region: CYLKLREYTKAVECCDKALGLDSANEKGLYRRGEAQLLMNEFESAKGDFE
• Concentration: 0.5 mg/ml
• Blocking Peptide: For anti-FKBP5 (ARP54713_P050) antibody is Catalog # AAP54713 (Previous Catalog # AAPP31508)
• Reference: Lekman,M., (2008) Biol. Psychiatry 63 (12), 1103-1110

Target Info

• Gene Symbol: FKBP5
• Gene Full Name: FK506 binding protein 5
• Alias Symbols: P54, AIG6, FKBP51, FKBP54, PPIase, Ptg-10
• NCBI Gene Id: 2289
• Protein Name: Peptidyl-prolyl cis-trans isomerase FKBP5
• Description of Target: FKBP5 is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. It is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It is thought to mediate calcineurin inhibition. It also interacts functionally with mature hetero-oligomeric progesterone receptor complexes along with the 90 kDa heat shock protein and P23 protein. The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It is thought to mediate calcineurin inhibition. It also interacts functionally with mature hetero-oligomeric progesterone receptor complexes along with the 90 kDa heat shock protein and P23 protein. This gene has been found to have multiple polyadenylation sites. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
• Uniprot ID: Q13451
• Protein Accession #: NP_004108
• Nucleotide Accession #: NM_004117
• Protein Size (# AA): 457
• Molecular Weight: 51 kDa
• Protein Interactions: LRRC40; CXorf57; EGLN1; AGO2; CACYBP; CHORDC1; AGO1; KIAA1279; NUDCD3; GLMN; CDC37; SUGT1; PTGES3; NUDC; AHSA1; DNAJB6; AURKB; IKBKG; IRS4; TUBA1A; TTC4; PYGL; PDCD2; CDK11A; HGH1; C14orf80; MCMBP; PNPLA2; ANKMY2; CDC37L1; MCM4; ILK; HSP90AB1; HSP90AA1; H